DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcc6

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1614	Identity:	442/1614 - (27%)
Similarity:	714/1614 - (44%)	Gaps:	283/1614 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WNWTQFCPTGLKPFANETNDLLPCF----------QEILLQLPVYTLFAAISAYNFGNQSRHVVR 66
            ||.|:     .:|.|....:|  ||          ..:.:..|:|.|:              :.|
  Rat    20 WNQTE-----QEPVAYHLLNL--CFLRAAGSWVPPMYLWVLGPIYLLY--------------IHR 63

  Fly    67 NG---LQL-RMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTA 127
            :|   |:: |:..|:..|...|.||     :.|               :|...:|.:|.|
  Rat    64 HGCCYLRMSRLFKIKMVLGFALILL-----YTF---------------NAAVPLWRIHRG----- 103

  Fly   128 RQYGELSHRGSLLIN-VVWLTVVVLDAVWLRTSRH---------FSWWPWSLATLVCDLLFGVTL 182
                 :.....|||: .||||.:......:...|.         |.:|      |:|.|:..:..
  Rat   104 -----MPQAPELLIHPTVWLTTMSFATFLIHMERKKGVRASGLLFGYW------LLCCLVPAIDT 157

  Fly   183 IPKGSA----------VYSSLPRSGVSAREDEGLLSQRYTYFQFD---LNESHLGHAQDEANLGS 234
            :.:.||          :.:.|..|.|.|......|..:..:|..|   ||..    .:.||:..|
  Rat   158 VQQASAGSFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSKPLNPC----PEAEASFPS 218

  Fly   235 RFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKL----------------HLAL---- 279
            :.:|.|...|:.||.. ||...:||:.|....:...|..:|                |..:
  Rat   219 KAMFWWASGLLWKGYR-KLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKGHSGMGTPE 282

  Fly   280 ---------SQSQSLWRALHRCFGVEFYLIGILRL-IADLSGFAGPLLLGGLLRQDHADPNQV-- 332
                     ||...|.||:.|.|...| |:|.|.| |:|...||.|.|| .|..:...|....
  Rat   283 TEAFLQPERSQRGPLLRAIWRVFRSTF-LLGTLSLVISDAFRFAVPKLL-SLFLEFMGDLESSAW 345

  Fly   333 --YYYALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE-ARGLKESKP--DLLNL 392
              :..|:.:|.|..|..:....:.:|:.::.|::|..:...:|||.|. :.|.::|..  |::||
  Rat   346 TGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNL 410

  Fly   393 MSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFS 457
            :|.|..|:|.|.:..:..|.:...:......|:..||.:.|..|.....|:|:|.::.|:.....
  Rat   411 VSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRSFHQ 475

  Fly   458 SGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATT 522
            ...|..|.:|...|:..::..:.||.:.||..|:.::..:|.:||..|....:|.::.:..:..:
  Rat   476 EEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALKTSAFLFSVSLVSFQVS 540

  Fly   523 PVLMCLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMD 585
            ..|:.|:.|.|..|:.  |.:.|...:.::.:|.:|.......|:.::.|::|.||..|:...:.
  Rat   541 TFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCLVQARVSFDRLAAFLC 605

  Fly   586 VPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSD-----------EQTSPT 639
            :..:|                         |...||.   .|.|...|           .|.||.
  Rat   606 LEEVD-------------------------PNGMVLS---PSRCSSKDRISIHNGTFAWSQESPP 642

  Fly   640 PFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQR 704
              .:..||:.:..|.|:.:.||||.||||.|||::..|...:|.|.::   ....||||..|:|.
  Rat   643 --CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIE---GSVAYVPQEAWVQN 702

  Fly   705 GTIRDNIVWGAQFDEQWYKTVLHACALEEDL-QILGGDLVGVGENGRTLSGGQRARVALARAVYQ 768
            .::.:|:.:..:.|..|.:.||.||||..|: ....|....|||.|..|||||:.|::||||||:
  Rat   703 TSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLSLARAVYR 767

  Fly   769 DKKVYLLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPS 831
            ...|||:||.|::|||||::.:.|..|  ..||:..|||:||..:.:...|:|||.:.:|.:
  Rat   768 RAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQILVLANGTI--- 829

  Fly   832 EYMTQSIELSLDED-----------ADDEQEP------------------------TVRRR---- 857
                  .|:...:|           .|..::|                        |..||
  Rat   830 ------AEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTPTRRPERP 888

  Fly   858 --------SVELSNQYDKKSLDSLLL------EELREYGHLSGNVFTCYWKAVTSPLAFTVLLSV 908
                    ....|....:.|||.:.:      |:..:||.:....:..|.:||.:||....|...
  Rat   889 RPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYTLFLF 953

  Fly   909 VLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSN 973
            :..|:.......||:.|..:..:|..:.     |..:|.::..          .|....||.:
  Rat   954 LCQQVASFCQGYWLSLWADDPVVDGKQM-----HSALRGSIFG----------LLGCLQAIGL-- 1001

  Fly   974 SLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFIL 1038
             ..::|..||   .|.:|:..:...||..|..:...||:.|.||.:|||||.:|:.||..:|..:
  Rat  1002 -FASMAAVFL---GGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKM 1062

  Fly  1039 NILLAQLAGL--VGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTH 1101
            ..||....||  || |.||: |.|...:.|:|::.:|...|..|......::||.|.:.|.:.:|
  Rat  1063 RTLLTYAFGLLEVG-LAVSM-ATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSH 1125

  Fly  1102 FTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAA 1166
            ..||.||...:|:.:|...|.......::|:.:....:..|.:|||..|:|||..||..|...|.
  Rat  1126 LAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAV 1190

  Fly  1167 ITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEE---QNASGSA 1228
            ::.:| .:.||.|..:|.||.:|..|..::.:..:.|..:|||||:..|:...:|   :..|.:|
  Rat  1191 LSKAH-LSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAA 1254

  Fly  1229 EPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPL 1293
            :|.  ||..|.:.||:..|.:|..|..|::|::.:..|.|::||||||||||:|:...|||:...
  Rat  1255 QPL--WPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEA 1317

  Fly  1294 THGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATL 1358
            |.|.|.:|.|.:..:.|..||.||.:|.|:|.||.|::|.|||......|..||.|::.......
  Rat  1318 TEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAF 1382

  Fly  1359 LVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAF 1423
            :....|.|..:....|::||.||:||||||||||:..:::.:||.|:::|..:::.:|.||...|
  Rat  1383 VTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWF 1447

  Fly  1424 KSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            ..||:|.||||||.:....|::|:|:|::.|.|:|..|.:... :||  .|||:
  Rat  1448 AQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQKG-LFY--RLAQE 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	439/1607 (27%)
		ABC_membrane	328..560	CDD:294371	55/240 (23%)
		ABCC_MRP_domain1	621..827	CDD:213217	82/219 (37%)
		ABC_membrane	948..1192	CDD:279056	74/245 (30%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	88/219 (40%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	436/1591 (27%)
		ABC_membrane	313..577	CDD:294371	64/264 (24%)
		ABCC_MRP_domain1	627..828	CDD:213217	78/205 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		5/54 (9%)
		ABC_membrane	950..1215	CDD:294371	82/288 (28%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	88/219 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810