DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC8

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_016873686.1	Gene:	ABCC8 / 6833	HGNCID:	59	Length:	1604	Species:	Homo sapiens

Alignment Length:	1650	Identity:	462/1650 - (28%)
Similarity:	739/1650 - (44%)	Gaps:	282/1650 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CFQEILLQLP-VYTLFAA--ISAYNFGNQSR--HVVRN------GLQLRMLSIRTFLAMVLALLP 88
            ||.:.|..:| |:.||..  |....:|:||.  |:..:      |..||.  |.||:.:.:.:..
Human    26 CFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRW--ILTFMLLFVLVCE 88

  Fly    89 VAK------------VFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGELSHRGSLLI 141
            :|:            :..:...|:...||...||....|                |.|:...|||
Human    89 IAEGILSDGVTESHHLHLYMPAGMAFMAAVTSVVYYHNI----------------ETSNFPKLLI 137

  Fly   142 N--VVW----LTVVVLDAVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSA 200
            .  |.|    :|..:....:|..:..||...:.|..|:. :|:|:.|:.:.:.:
Human   138 ALLVYWTLAFITKTIKFVKFLDHAIGFSQLRFCLTGLLV-ILYGMLLLVEVNVI----------- 190

  Fly   201 REDEGLLSQRYTYFQF--------DLNESHLGHAQDEANLGSRFLFHWV---------QPLILKG 248
                  ..:||.:|:.        ||.:..:...|...||.|:..:.|:         :|:.|:.
Human   191 ------RVRRYIFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRA 249

  Fly   249 VAGKLRKIEDLFDLPDAL----NITRLSEKLHLALSQ-------SQSLWRALHRCFGVEFYLIGI 302
            : ||         ||.|:    |..||.|.....:.:       ::::|:||...||....|...
Human   250 I-GK---------LPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSST 304

  Fly   303 LRLIADLSGFAGPLLLGGLLRQDH-ADPNQV----------------------YYYALGLFGSTL 344
            .|::|||.||||||.:.|::  || ...|.|                      |..|:.||.:.|
Human   305 FRILADLLGFAGPLCIFGIV--DHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALL 367

  Fly   345 LSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKESKPD-----LLNLMSTDTDRIVNSC 404
            |.........:......:.:|..:...||.|.:.......|..:     :.||::.||::::
Human   368 LQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLM--- 429

  Fly   405 ISFHFF-----WSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAK 464
              :.||     |::|.::...:.|||..||.:.|.|.....||.|:..::|.::.......:...
Human   430 --WFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYS 492

  Fly   465 DARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLL 529
            :.||..|.|.::|.|.:|:.|||:||.|::...|::|:..|.......::.::.....|:...|:
Human   493 NERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLI 557

  Fly   530 TF--GVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNL--- 589
            ||  .||.........|..:.|::|.::|:.||.....|:...::|.||::::.:.:....:
Human   558 TFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREE 622

  Fly   590 ----------DYSSYYNPIMRG---------SGGSGAGDDAPLDAPK------------ASVLQM 623
                      ..:|.|..:..|         ||.|......||....            ...||.
Human   623 QCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQS 687

  Fly   624 KCASFCHDSDE--------------QTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIV 674
            ...|...|:|.              ...||   :.:|.:.|..|||..|.|.||.||||.|.|.:
Human   688 LVPSADGDADNCCVQIMGGYFTWTPDGIPT---LSNITIRIPRGQLTMIVGQVGCGKSSLLLAAL 749

  Fly   675 ANLQCTDGEVC----------------VQELTTGF--------GYVPQSPWLQRGTIRDNIVWGA 715
            ..:|...|.|.                .:|..|..        .|..|.|||...|:.:||::.:
Human   750 GEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFES 814

  Fly   716 QFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVL 779
            .|::|.||.|:.||:|:.|:.|| .||...:||.|..||||||.|:::|||:||...|..|||..
Human   815 PFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPF 879

  Fly   780 SSLDAHVARHIIKHCILRLLK--HKTRIVVTRNIQLFFHANQILQVKDGQLLPSEYMT--QSIEL 840
            |:||.|::.|:::..||.||:  .:|.::||..:|...||:.|:.:|||.:.....:.  |..|.
Human   880 SALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC 944

  Fly   841 SLDE---------DADDEQEPTVRRRSVELSNQYDK--KSLDSLLLE---------ELREYGHLS 885
            .|.|         |.:.|:|....|::.|......:  .|.|.||.:         |..|..:||
Human   945 QLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLS 1009

  Fly   886 GNVF---TCYWKAVTSPL--AFTVLLS-VVLMQLTRNL----SDAWLAYWV-TETTLDPHKNDTS 939
            ..:.   ...|:|....|  |..:||| :|..||.:::    .|.|||.|. :..||.|...:.|
Human  1010 SMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCS 1074

  Fly   940 LDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVM 1004
            |         ..|.....|.  |..:||.:.....::.|..:....:.|:|.|..:|..||.:::
Human  1075 L---------SQECTLDQTV--YAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRII 1128

  Fly  1005 FAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPM 1069
            .|...||:.|.:|.||||||||.||:|..:|..|..|.......|.||.|..|..|...:.::|:
Human  1129 LAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPL 1193

  Fly  1070 VPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIK 1134
            ..:...:|:.:|.||||:::|......||.:||.||::||||||:.|...|||:......:.:..
Human  1194 AIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNI 1258

  Fly  1135 AQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTT-----NPGLVGLCISYALSITGQLGD 1194
            |.|..:||.:||.:|::.:|..:|    |:||:|:...:     :.|||||.::|||.::..|..
Human  1259 ASLFLTAANRWLEVRMEYIGACVV----LIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNW 1319

  Fly  1195 LLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEP---PFGWPTQGVLSFREVQLSYREHLAPA 1256
            ::..:|:.|.:|.||:||...|:.|.| :..|...|   |..||.||.:..:.:.:.|...|.|.
Human  1320 MVRNLADMELQLGAVKRIHGLLKTEAE-SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPV 1383

  Fly  1257 LRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVIT 1321
            |:.:.......::|||.||||:||:|...|..|:.....|.|.:|.:::..|||..||.|:.:|.
Human  1384 LKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIIL 1448

  Fly  1322 QEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQL-GGLDGKVETCGNNLSAGQRQLL 1385
            |:|.||.||:|.||||.....||.:|.|:: .|...|:|:.| ||||..:...|.|.|.|||||.
Human  1449 QDPVLFSGTIRFNLDPERKCSDSTLWEALE-IAQLKLVVKALPGGLDAIITEGGENFSQGQRQLF 1512

  Fly  1386 CLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDG 1450
            |||||.::...:..:||.|:::|..::..:|:.:..||...|::.||||:..:.:.|.:|||..|
Human  1513 CLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRG 1577

  Fly  1451 RICEEGNPQSLASDSSTIFYGMLLA 1475
            .|.|...|:.|.|...::|...:.|
Human  1578 AILEFDKPEKLLSRKDSVFASFVRA 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	461/1645 (28%)
		ABC_membrane	328..560	CDD:294371	58/265 (22%)
		ABCC_MRP_domain1	621..827	CDD:213217	85/246 (35%)
		ABC_membrane	948..1192	CDD:279056	82/248 (33%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	82/220 (37%)
ABCC8	XP_016873686.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720