DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abcc12

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1351	Identity:	377/1351 - (27%)
Similarity:	664/1351 - (49%)	Gaps:	137/1351 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 FQFDLNESHLGHAQDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLP-DALNIT-----RL- 271
            |:|..|    .|..|:|...|...|.|:.|::.:....:|.: :.||..| |..:|.     ||
Zfish    60 FRFASN----SHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDE-DSLFLSPHDGAHINGERFQRLW 119

  Fly   272 -SEKLHLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGP-LLLGGLLRQ-DHADPNQVY 333
             .|...:.|.:: ||...:.|.....|.:..:..::...:.|.|| :|:..:|.. :.::|:.|
Zfish   120 DEEVARVGLEKA-SLSAVIMRFQKTRFIVSFLASVMFAFAVFVGPSILVYEILNYVEQSEPSTV- 182

  Fly   334 YYALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSI----YRKALEARGLKE-SKPDLLNLM 393
            .:.:|:..:..|:......|...:..|:::..|.|..:.    ::|.:..|.|.. :..:.:|::
Zfish   183 VHGVGVCVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISLRSLTTITVGETINVL 247

  Fly   394 STDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSS 458
            ::|..|:.::.|...|...:|..|...:......||...|.|::...:.:||...:|:.||:|..
Zfish   248 TSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFILGYTALIGILVYLIFLPIQFSIARLIGVFRR 312

  Fly   459 GLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTP 523
            ..::..|.|:....|.:...|.||:.|||:.|...|..:|:.|...|.|..|:.::........|
Zfish   313 RAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSSLTTIVP 377

  Fly   524 VLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPN 588
            .|..::||.|...:..||:.||.||.:|:...:...:...|:.:..:.||.|::.|::::|.|.|
Zfish   378 TLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSMGLLPFSVKAVAEAKVALTRLKRIMLVQN 442

  Fly   589 LDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFR----------- 642
              ...|..            .|..:|.  |.|::....|:....|:.||..|..
Zfish   443 --PKGYLT------------QDKNMDL--ALVMEKATFSWSPTDDKNTSQMPENPSQNGKHKAES 491

  Fly   643 ---MKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQR 704
               :::|::.:..|.|:.:.|.||.||:|.:|:|:..:....|.|.....   ..||.|..|:..
Zfish   492 QPSLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGT---LAYVSQQAWIFH 553

  Fly   705 GTIRDNIVWGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENGRTLSGGQRARVALARAVYQ 768
            ||:||||:.|..|||..|.:|::||.|:.||.||. ||...:||.|..|||||:.||:||||||.
Zfish   554 GTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYS 618

  Fly   769 DKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDG------- 826
            ::.::||||.||::||||.:||.:.||.:.||.|:.|:||..:|.....::::.:.:|
Zfish   619 NRDIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSVILVTHQLQYLEFCDEVMLLDNGEIKEAGT 683

  Fly   827 ------------QLLPSEYMTQSIELS----LDEDADDEQ----EPT---VRRRSVELS------ 862
                        ||:.:.::.|:.|.:    ..|..|.||    ||.   :...:.::|
Zfish   684 HSDLMKTKGRYSQLITNVHLEQNNERADSKPQTEHNDSEQTNPDEPKANGIENPAFDMSDEKPAT 748

  Fly   863 NQYDKKS------LDSLLLEELREYGHLSGNVFTCYWKAVTS-PLAFTVLLSVVLMQLTRNLSDA 920
            |:..|.|      .|.|:..|:.:.|.::...:..|.:|... .|.|.|:|...|:..:...|:.
Zfish   749 NETPKDSSETKGKKDQLVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTLLVGSTAFSNW 813

  Fly   921 WLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTT-----------KFYLSIFTAIAVSNS 974
            ||:||:.:.:                   ||.:.|..|:           .||..::..|.::..
Zfish   814 WLSYWLDQGS-------------------GNNSSSNATSNSGNISENPDLSFYQMVYGVIIIAMI 859

  Fly   975 LVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILN 1039
            ::::.:.:.|....::::..:|:.:.|:::.:..:|||.|..||::||||.|.:.||..|||.:.
Zfish   860 VLSILKGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNME 924

  Fly  1040 ILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTE 1104
            ..|.....:...|.......|:|.:.::.:..|:.::...::.:.|.:||:.:.:.||..:..|.
Zfish   925 NFLQFCLIVTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTS 989

  Fly  1105 TLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLG---TLLVGGAGLLAA 1166
            |:|||:||.:.....::...|::..:.:....:..:|..:||:..|.:|.   ||:|   .|...
Zfish   990 TIQGLSTIHAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIV---SLFVV 1051

  Fly  1167 ITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQ--LEEEQNASGSAE 1229
            ::.:.|.||.|.||.:||.:.:||.|..::....|.|.:..:|||:.:|:.  :.|.......|.
Zfish  1052 LSPNETINPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGPRRVKDAN 1116

  Fly  1230 PPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLT 1294
            .|.|||.:|.::|:...:.||::....|..:.......|::|||||||:||:|:..||.|:|...
Zfish  1117 IPAGWPQEGTITFKNYSMRYRDNTPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPA 1181

  Fly  1295 HGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLL 1359
            .|.|.:|.:::..|.|..||.::.||.|:|.||.||||.||||.:.:.|.|:|.|::.:.....:
Zfish  1182 EGTILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTI 1246

  Fly  1360 VQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFK 1424
            .:....|...|...|.|.|.|:|||:|:|||||:|:|::.:||.|:::|.|:|..||..:|:.|:
Zfish  1247 SKLPEKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQ 1311

  Fly  1425 SCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLA 1475
            .||:|.||||:..:...|||:|:|.|::.|...||.|....:::|..:|.|
Zfish  1312 HCTMLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPNSLFASLLAA 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	375/1346 (28%)
		ABC_membrane	328..560	CDD:294371	56/236 (24%)
		ABCC_MRP_domain1	621..827	CDD:213217	81/239 (34%)
		ABC_membrane	948..1192	CDD:279056	63/257 (25%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	86/219 (39%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	373/1339 (28%)
		ABC_membrane	149..414	CDD:294371	61/265 (23%)
		ABCC_MRP_domain1	457..677	CDD:213217	81/222 (36%)
		ABC_membrane	809..1077	CDD:294371	68/289 (24%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	86/219 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720