DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7806 and cftr

DIOPT Version :9

Sequence 1:NP_609207.1 Gene:CG7806 / 34140 FlyBaseID:FBgn0032018 Length:1487 Species:Drosophila melanogaster
Sequence 2:NP_001038348.1 Gene:cftr / 559080 ZFINID:ZDB-GENE-050517-20 Length:1485 Species:Danio rerio


Alignment Length:1494 Identity:396/1494 - (26%)
Similarity:667/1494 - (44%) Gaps:279/1494 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 DEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLP--DALNITRLSEKLH-------LALSQSQ 283
            ::||..||:.|.|..|::.||...|||. .|::..|  ||.:|  |:|:|.       .:..:..
Zfish     7 EDANCLSRYFFWWTNPIMRKGFKEKLRP-SDVYQAPSQDAADI--LAERLEKEWDREVASGKKKP 68

  Fly   284 SLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLRQ-DHA-DPNQV--YYYALG---LFG 341
            ||.||:.||:...|.|.|.|..|.:.:....|.|||.::.. |.| :|.:.  |:.|.|   ||.
Zfish    69 SLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERANGYFLAFGLGLLFT 133

  Fly   342 STLL---SAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE--ARGL-KESKPDLLNLMSTDTDRI 400
            :..|   .|:...|.      :.|::|:.:.:.||:|.|:  :|.| |.|...|::|||.:..:.
Zfish   134 ARFLLLQPAMFGLHH------LGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKF 192

  Fly   401 VNSCISFHFFWSIPFKLFTTLYLL--------YLQLGAAFLAGVIFAALLIPINRWLAKRIGIFS 457
            ..|....||.|..|.:......|:        :..|.|..|.||:.|.|...:..:.|:::    
Zfish   193 DQSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKV---- 253

  Fly   458 SGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSK---RKYLDAMCVYFW 519
              |:|.|  ||:.|:|.|:....:|...||:|..|.|:.:||:|::...|   .:|..:...:|.
Zfish   254 --LLTNK--RLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFS 314

  Fly   520 ATTPVLMCLLTFGVSVLMG-NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVS----IKR 579
            |...::..::...:|  .| |.....||.:...:|.|.:      ...|.|.|:.|..    |.:
Zfish   315 AIFVIVAAVVPHALS--RGINLRRIFTTLSYCMVLRMTV------TRQLPGSIQMWYDTMRLIWK 371

  Fly   580 VQQLMDVPNLDYSSYYNPI--MRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDE-------Q 635
            :::.:.........|...|  :.....:.:.|:.|.:..: .:.|...|:..|:.|.       .
Zfish   372 IEEFLSKEEYKLMEYDLSITELELQDVTASWDEGPGELLE-RIKQENKANGHHNGDAGLFFTNLY 435

  Fly   636 TSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSP 700
            .:|.   :|||::.:|.|:::.:.|.:|.||||.|..|:..|..:.|::   ..:....|..|:.
Zfish   436 VAPV---LKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKI---RHSGRISYSSQTA 494

  Fly   701 WLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALAR 764
            |:..|||||||::|..:||..||:|:.||.|||||..| ..|...:.|.|..|||||:|||||||
Zfish   495 WIMPGTIRDNILFGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALAR 559

  Fly   765 AVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQL- 828
            |||:|..:||||...:.||....:.|...|:.:|:..||||:||..|:....|::||.:.:|:. 
Zfish   560 AVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESF 624

  Fly   829 -------LPSE------------------------YMTQSI-ELSLDEDAD-------------- 847
                   |.||                        .:|::: .:|:||.|.              
Zfish   625 FYGTFPELQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQPERSAFRQVPPT 689

  Fly   848 -----DEQEPTV--------RRRS-VELSNQYDKKSLD----SLLLE-ELREYGHLSGNVFTCYW 893
                 ||::.:|        |:.| :::..:..:::|.    ||:.| ||.:...:..:|:..:.
Zfish   690 KPMYIDERKASVIVNPLGVARKASFIQVPEEEVRRTLPDRKFSLVPENELVDESFMGSDVYHNHG 754

  Fly   894 KAVT-----SPLAFTV-----------------LLSVV--------LMQLTRNLSDAWLAYWVT- 927
            ..:.     |.|||..                 .||||        |...||.|||:  .|.:| 
Zfish   755 VHMAGQRRQSVLAFMTNAQGQGRREHLQSSFRRRLSVVPQSELASELDIYTRRLSDS--TYDMTG 817

  Fly   928 ------------------ETTLDPHK---------NDTSLDHILM-------------------- 945
                              |.|.:..|         |:.||.::|:                    
Zfish   818 ILEEENIEACLTDEIDEIEETFETTKWNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLI 882

  Fly   946 ------------RPTV---GNETESGHT-------TKFYLSIFTAIAVSNSLVTLA--RAFLFAY 986
                        .|.:   .|.:.||.|       |..|..::..:|.|.||:.:.  |...|.:
Zfish   883 TDELWREEHQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLLAMGFFRGLPFVH 947

  Fly   987 AGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGA 1051
            ..|..:..:|:|:|..|:.|..:..:....|||:|||:.|..|:||.||.::...:.....:||.
Zfish   948 TTITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGC 1012

  Fly  1052 LCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMR 1116
            :.|.....|::.|...|:..|::.:::.:....:.:|:|.:.|.||:::|...:|:||.|||:..
Zfish  1013 ILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRAFE 1077

  Fly  1117 ASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLC 1181
            ....|:..|...|...........:..:|...|..:|.......|..:|  ..::...||.:|:.
Zfish  1078 RQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAAWIA--VGTNQDKPGEIGII 1140

  Fly  1182 ISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEE--------------QNASGSAEPPF 1232
            |..|:.|.|.....:......:..:.:|:|:.:::.|..|              :|....|:.  
Zfish  1141 ICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETPKPDKGKDSDLIIENVDAQADS-- 1203

  Fly  1233 GWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGE 1297
            .||.:|.:..|.:.:.|.|.....|:.::|..|..:|:||:||||:||:|:..|||::. .|.||
Zfish  1204 SWPHRGQIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLV-YTDGE 1267

  Fly  1298 IRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQ 1362
            |.:|.||...:||...|:..||:.|:.|:|.|.:|.||||.....|.|:|...:.....|::.|.
Zfish  1268 ISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVIEQF 1332

  Fly  1363 LGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCT 1427
            ...||.::|..|..||.|.:||:||||::|..|:::.:||.:::||..:...:::.||.:|.:||
Zfish  1333 PDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCT 1397

  Fly  1428 LLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQDIDPGE----FIRSN 1487
            :|...|::..|......:::|.|::....:.|.|.:::|.      |.|.|.|.|    |.|.|
Zfish  1398 ILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNETSH------LKQAISPAERLKLFPRRN 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7806NP_609207.1 MRP_assoc_pro 6..1472 CDD:188098 388/1473 (26%)
ABC_membrane 328..560 CDD:294371 65/254 (26%)
ABCC_MRP_domain1 621..827 CDD:213217 82/213 (38%)
ABC_membrane 948..1192 CDD:279056 64/255 (25%)
ABCC_MRP_domain2 1238..1458 CDD:213211 75/219 (34%)
cftrNP_001038348.1 AAA 1..1485 CDD:333001 396/1494 (27%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 653..826 33/174 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1485 2/4 (50%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1483..1485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53842
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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