DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1612	Identity:	490/1612 - (30%)
Similarity:	781/1612 - (48%)	Gaps:	237/1612 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVDWGDFAWNWTQFCPTGLKPFANETNDLLPCFQE-ILLQLPVYTLFAAISAYNFGNQSRHVVRN 67
            ::|| :..||             ....|...|||. :|:.:|.:.|:|....| |...||| .|.
Human    33 IMDW-NVTWN-------------TSNPDFTKCFQNTVLVWVPCFYLWACFPFY-FLYLSRH-DRG 81

  Fly    68 GLQLRMLS-IRTFLAMVLALLPVAKVF-AFHQQGVELFAADLLVVSAECI-MWVVHSGFLLTARQ 129
            .:|:..|: .:|.|..:|.::..|.:| :|.::...:|.|.:.:||...: :.::.:.||:...:
Human    82 YIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLER 146

  Fly   130 YGELSHRGSLLINVVWLTVVVLDAVWLRTSRHFSWWPWSLATLV-----CDLLFGVTLIPKGSAV 189
            ...:...|.:|  ..||..:|.....||:         .:.|.:     .||...:|..     |
Human   147 RKGVQSSGIML--TFWLVALVCALAILRS---------KIMTALKEDAQVDLFRDITFY-----V 195

  Fly   190 YSSLPRSGVSAREDEGLL--------SQRYTYFQFDLNESHLGHAQDEANLGSRFLFHWVQPLIL 246
            |.||            ||        |.|...|...:::.: ...:..|:..||..|.|:..||:
Human   196 YFSL------------LLIQLVLSCFSDRSPLFSETIHDPN-PCPESSASFLSRITFWWITGLIV 247

  Fly   247 KGVAGKLRKIEDLFDL----------------------------------------PDALNITRL 271
            :|....|.. .||:.|                                        |...:....
Human   248 RGYRQPLEG-SDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDA 311

  Fly   272 SEKLHLALSQS------QSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLR--QDHAD 328
            :|::...:.:|      .||::.|::.||..|.:....:.|.||..|:||.:|..|::  .|...
Human   312 NEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKA 376

  Fly   329 PN-QVYYYALGLFGSTLLSAVCATHFDWRMAMVS-MKMRVGVVNSIYRKAL----EARGLKESK- 386
            |: |.|:|.:.||.:..|..: ..|..:.:..|| |:::..|:.::|||||    .||  |.|.
Human   377 PDWQGYFYTVLLFVTACLQTL-VLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSAR--KSSTV 438

  Fly   387 PDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAK 451
            .:::||||.|..|.::.....:..||.|.::...||||:|.||.:.||||....|::|:|..:|.
Human   439 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM 503

  Fly   452 RIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCV 516
            :...:....|.:||.|:....|.:.|.|.:|:.|||..|..|:..:|||||:.|.|..||.|:..
Human   504 KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 568

  Fly   517 YFWATTPVLMCLLTFGVSVLM--GNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKR 579
            :.|..||.|:.|.||.|.|.:  .|.|.|.|.:.|:||..:|..|||..|.|::.:::|.||:||
Human   569 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 633

  Fly   580 VQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMK 644
            ::..:....|:..|.....::..||:.:             :.::.|:|.....:     |..:.
Human   634 LRIFLSHEELEPDSIERRPVKDGGGTNS-------------ITVRNATFTWARSD-----PPTLN 680

  Fly   645 DINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRD 709
            .|...|..|.||.:.|.||.||||.|||::|.:...:|.|.::   ....||||..|:|..::|:
Human   681 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK---GSVAYVPQQAWIQNDSLRE 742

  Fly   710 NIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVY 773
            ||::|.|.:|.:|::|:.||||..||:|| .||...:||.|..|||||:.||:||||||.:..:|
Human   743 NILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIY 807

  Fly   774 LLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP------ 830
            |.||.||::||||.:||.::.|  ..:||:||||:||.::......:.|:.:..|::..
Human   808 LFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 872

  Fly   831 --------SEYMTQSIELSLDEDADDEQEPTVR-----------------------RRSVELSNQ 864
                    :|::........::||::.....|.                       :|.:..|:.
Human   873 LLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSS 937

  Fly   865 YD-------------------KKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVL 910
            |.                   |:....|:..:..:.|.:..:|:..|.||:...::|..:...:.
Human   938 YSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMC 1002

  Fly   911 MQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSL 975
            ..::...|:.||:.|    |.||..|.|. :|                ||..||::.|:.:|..:
Human  1003 NHVSALASNYWLSLW----TDDPIVNGTQ-EH----------------TKVRLSVYGALGISQGI 1046

  Fly   976 VTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNI 1040
            .....:...:..||.|:..:|..||..::.:..:||:.|..|.::||||.:.:|||..:|.::.:
Human  1047 AVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKM 1111

  Fly  1041 LLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTET 1105
            .:..|..::||..|.|.|.|...::|.|:..||..:|:.|..:||.:|||.|.:.||:|:||.||
Human  1112 FMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNET 1176

  Fly  1106 LQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITAS 1170
            |.|::.||:.....||.....:|::|:.||......|.:|||:||:.:|..:|..|.|.|.| :.
Human  1177 LLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI-SR 1240

  Fly  1171 HTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEE-----QNASGSAEP 1230
            |:.:.|||||.:||:|.:|..|..|:...:|.|..:|||||:.:|.:.|:|     |..:    |
Human  1241 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA----P 1301

  Fly  1231 PFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTH 1295
            |..||..|.:.||...|.|||.|...||.|.......|::||||||||||:|:...|.|:.....
Human  1302 PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1366

  Fly  1296 GEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLV 1360
            |||.:|.:|:..:.|..||.:|.:|.|:|.||.|::|.||||...:.|.|:|.:::.:.....:.
Human  1367 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1431

  Fly  1361 QQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKS 1425
            .....||.:....|.|||.|||||:|||||||:..|::.:||.|:.:|.|:|..||..:|..|:.
Human  1432 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1496

  Fly  1426 CTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            ||:|.|||||..:....|:||||.|.|.|.|.|..|..... :||.|  |:|
Human  1497 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG-LFYSM--AKD 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	487/1603 (30%)
		ABC_membrane	328..560	CDD:294371	85/240 (35%)
		ABCC_MRP_domain1	621..827	CDD:213217	83/208 (40%)
		ABC_membrane	948..1192	CDD:279056	82/243 (34%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	94/219 (43%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720