DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and CG5789

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001247286.1	Gene:	CG5789 / 42928	FlyBaseID:	FBgn0039207	Length:	1402	Species:	Drosophila melanogaster

Alignment Length:	1404	Identity:	423/1404 - (30%)
Similarity:	659/1404 - (46%)	Gaps:	224/1404 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 QDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLHLAL------------ 279
            :..||:.|:.:|.|..||:.:|    .|:..:..||...|...| ||:|...|
  Fly    13 RQHANIISQLIFAWAIPLLYRG----SRRGLNTDDLTQCLKEDR-SEQLGDRLEDQWFKELERSH 72

  Fly   280 --SQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLL-------------------- 322
              .|...|..||.|||.....:.|::..|..:.....|.:|..||
  Fly    73 RKKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDIS 137

  Fly   323 ------RQDHADPNQVYYYALG------------------------------------------- 338
                  |...|.||.|...|:.
  Fly   138 ISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILD 202

  Fly   339 ----------------LFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKESKP 387
                            |..|||.......|.|.|..::..:||:...:.||||.|.. .:|.:..
  Fly   203 QTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRL-SMKTAGQ 266

  Fly   388 D----LLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAAL-LIPINR 447
            .    |:||:|.|.:|:....|..|:.|.:|.:...|.||::|.:|...:.||:...| .:|:..
  Fly   267 TPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQT 331

  Fly   448 WLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLD 512
            .|:|...:....:....|||:....|.:||.:.||:.|||..|...:...|:.|::.:....||.
  Fly   332 ALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLR 396

  Fly   513 AMCVYFWATTPVL----MCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNA--FPWVLNGLI 571
            .    |:.:|.|.    ...:|...:.|||..:.|...: |.|..|.::..:.|  :|..::...
  Fly   397 G----FYLSTMVFTERSTLYITLAAAALMGQTITADFVF-SAASYYNILQLVAAIWYPLAVSFGA 456

  Fly   572 EAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQT 636
            ||.||::|:|..:.:...:        .|..|.:...|....|:...::..:. ||:..:..::|
  Fly   457 EALVSLRRIQDFLMLEGRE--------ERTQGLTHKRDQEGGDSRAVTIKDIN-ASWDIEKPQKT 512

  Fly   637 SPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPW 701
                  ::.||:.|:.|||..:.||||.||||.|..::..|...||.|.:|   ....|..|.||
  Fly   513 ------LQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ---GDLSYAAQEPW 568

  Fly   702 LQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARA 765
            |..|::|:||::|.:||.:.|:.|...|||..|.|.| .||...|||.|.:||||||||::||||
  Fly   569 LFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARA 633

  Fly   766 VYQDKKVYLLDDVLSSLDAHVARHIIKHCI-----LRLLKHKTRIVVTRNIQLFFHANQILQVKD 825
            ||:..::||:||.||::||||.||:....|     |..|| .|||:||..:.....|:.|:.|..
  Fly   634 VYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLK-ATRILVTHQVHFLSEADVIVIVDQ 697

  Fly   826 GQLL---------------------PSE------YMTQSIELSLDE-DADDEQEPTV-------- 854
            |::|                     |.|      ...|:..||::. ::|||..|.:
  Fly   698 GRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGVKDGYQ 762

  Fly   855 --RRRSVELSNQYDKKSLDSLLLE---------ELREYGHLSGNVFTCYWKAVTSPLAFTVLLSV 908
              |::|   |:.:..|||||..|:         |.:..|.:|..|:..|:.|.::.|:|:.::.|
  Fly   763 QLRKQS---SSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGSTLLSFSFMVFV 824

  Fly   909 VLM-QLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVS 972
            ::| |:..:.||.:...|    |...|:.              ::.|:..:|...:.|:.|:.::
  Fly   825 MVMSQVVCSSSDFFANIW----TQQEHQR--------------SQGEATFSTFECMYIYGALIIA 871

  Fly   973 NSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFI 1037
            ..::|..|.|||....:.|:..:|:::...::.|...|||.|..||||||||.|...:|:.||..
  Fly   872 VVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRA 936

  Fly  1038 LNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHF 1102
            :...:.....:.|.|.|.....|.|...::.:..:.:.:.:.|...|:|:|||.....||:::|.
  Fly   937 MMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHL 1001

  Fly  1103 TETLQGLTTIRSMRASPRFQRDFQVKLE-ESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAA 1166
            :.:|.||..|||.:......::|.:..: .|...|||. |....|.|.|..:..:.:... ..:.
  Fly  1002 SASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTM-AVNTTLGLWLDCVSCIFLTSV-TFSF 1064

  Fly  1167 ITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEPP 1231
            |.:|.||..|.|||.|:.|:.:||.:...:..|||:.|::.:|||:.||.:||:|. |.|...||
  Fly  1065 IISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEP-ALGEKTPP 1128

  Fly  1232 FGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHG 1296
            ..|||:|.:.||.:...|..:.:|.||.:....||..::||||||||||:|::.||.|:|.: .|
  Fly  1129 QQWPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHI-EG 1192

  Fly  1297 EIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQ 1361
            ||.:|.:...|:.|.:||.||.:|.|:|.||..|:|.||||...:.|:|:|.|:::    ..|.:
  Fly  1193 EIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALED----VELRK 1253

  Fly  1362 QLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSC 1426
            .:.|||..|...|.|.|.|||||||||||:|:|.||:.:||.|:|:|.::|..||:.:|..||.|
  Fly  1254 AIPGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQC 1318

  Fly  1427 TLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDS 1465
            |:|.:||||..:...|||||:|.|...|...|..|...|
  Fly  1319 TVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKS 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	423/1404 (30%)
		ABC_membrane	328..560	CDD:294371	67/299 (22%)
		ABCC_MRP_domain1	621..827	CDD:213217	87/211 (41%)
		ABC_membrane	948..1192	CDD:279056	69/244 (28%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	98/219 (45%)
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	423/1404 (30%)
		ABC_membrane	214..441	CDD:294371	63/232 (27%)
		ABCC_MRP_domain1	495..699	CDD:213217	87/214 (41%)
		ABC_membrane	863..1088	CDD:294371	65/226 (29%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	98/219 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I4365
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870