DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Mrp4

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster

Alignment Length:	1325	Identity:	390/1325 - (29%)
Similarity:	647/1325 - (48%)	Gaps:	140/1325 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 SRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKL------HLALSQSQSLWRALHRC 292
            |..:|.:..|::.||....|.: :||:..........|.::|      .:|.:::..|.|||.:.
  Fly    21 SSLMFCFALPVLFKGRKKTLEQ-KDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRLGRALTKV 84

  Fly   293 FGVEFYLIGILRLIAD-LSGFAGPLLLGGLLRQ---DHADPNQVYYYALGLFGSTLLSAVCATH- 352
            ||...::.|:..|..: |:....|:.|.|::..   :..|.::...:|.||...::.| ||..|
  Fly    85 FGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFS-VCIGHP 148

  Fly   353 FDWRMAMVSMKMRVGVVNSIYRKALE----ARGLKESKPDLLNLMSTDTDRIVNSCISFHFFWSI 413
            :...:..:.||||:.:.:.||||||.    |.| ..:...::||:|.|..|.....|:.|:.|..
  Fly   149 YMLGLLHLGMKMRIALSSLIYRKALRLSRTALG-DTTVGQVVNLLSNDVGRFDLVLINVHYLWIA 212

  Fly   414 PFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGA 478
            |.:|....||:||::|.:.:.||....|.:|...:|.||..:.........|.|:....|.:.|.
  Fly   213 PLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGI 277

  Fly   479 KQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTFGVSVLMGNPLIA 543
            :.||:.|||..|...:...|..|:..:.:..|:..:.:.|......:....:....||:||.|.|
  Fly   278 QVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNA 342

  Fly   544 STTYTSVALLYMLIGPLNA-FPWVLNGLIEAWVSIKRVQQLMDVPNL---DYSSYYNPIMRG--- 601
            ...:...|...:|...:.. ||..::...|..||::|::..|..|..   |.|...|...:.
  Fly   343 EKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESP 407

  Fly   602 SGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGK 666
            :|.|..|:..|.:..:.|..|.:..|      ....||   ::|||:.:...:||.:.||||.||
  Fly   408 NGDSPKGNGIPENLIEFSQFQARWES------HSLEPT---LEDINLQLGRRKLVAVIGPVGAGK 463

  Fly   667 SSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACAL 731
            ||.:.||:..|   .||.....:...:.|..|.|||..||:|.||::|..:|:..|:||:..|||
  Fly   464 SSLIQAILGEL---PGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCAL 525

  Fly   732 EEDLQILG-GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI 795
            |.|.::|. ||...|||.|.:|||||:||::||||||:...:|||||.||::|.||.||:...|:
  Fly   526 ERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM 590

  Fly   796 LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPSEYMTQSIELSLD---------EDADDEQE 851
            ...|:.:..|:||..:|....|:.|:.:..|::......:......||         :||:|..|
  Fly   591 RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDE 655

  Fly   852 --------------PTVRRRS-------------VELSNQYDKKSLD-SLLLEELREYGHLSGNV 888
                          |::.||.             ..||:..:..:.: ||.::|.|..|.:...:
  Fly   656 IDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGL 720

  Fly   889 FTCYWKAVTSPLAFTVLLSVVLM----QLTRNLSDAWLAYWV-------TETTLDPHKNDTSLDH 942
            :..|   :||..::.::..:|.:    |:..:.:|.:|:|||       |:...||.
  Fly   721 YKEY---LTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQ-------- 774

  Fly   943 ILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAK 1007
                            ..:|   |.|:.|:..:.|:.|..||....::::..:|..:.:.:..|.
  Fly   775 ----------------DMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAA 820

  Fly  1008 FNFFDITSVGRILNRFSSDTNTVDDSLPFI-LNI--LLAQLAGLVGALCVSLYAMPWLGLVIIPM 1069
            ..||:....||||||||.|...:|:.||.: |::  |...|.|::..:|::   .|:..::.:.:
  Fly   821 MYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICIT---NPYYLILTLAL 882

  Fly  1070 VPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIK 1134
            ..|:..:::.|...|||:|||.:.|.||:|:|.:.|:.||.|||::.|......:|....:....
  Fly   883 AIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSS 947

  Fly  1135 AQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTN----PGLVGLCISYALSITGQLGDL 1195
            ...|..|..:.....|....||.:      ..|..::..|    ||.|||.|:.|:.:||.:...
  Fly   948 GYYTFLATNRAFGYYLDCFCTLYI------VIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWA 1006

  Fly  1196 LHAVAETEQELVAVERIDQYLQLEEE---QNASGSAEPPFGWPTQGVLSFREVQLSY--REHLAP 1255
            :...||.|..:.||||:.:|.::|.|   .:..|....| .||.:|.:...::.|.|  ......
  Fly  1007 MRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSP-SWPEKGEIIAEDLCLRYFPDPQAKY 1070

  Fly  1256 ALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVI 1320
            .|:.:.|:....|::||||||||||:|::.||.|:: ...|.|.:|:.:...:.|..||.:|.:|
  Fly  1071 VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLS-YNEGIITIDERDTADMGLFDLRSKISII 1134

  Fly  1321 TQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLL 1385
            .|||.||.|::|.||||...:.|:::|.|::......|:.:...||..|:...|:|.|.|||||:
  Fly  1135 PQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLV 1199

  Fly  1386 CLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDG 1450
            |||||:|:..:|:.:||.|:|:|.::|..||..:|:.|:.||:|.|||||..:...||::|:|.|
  Fly  1200 CLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAG 1264

  Fly  1451 RICEEGNP-QSLASDSSTIFYGMLL 1474
            .:.|.|:| :.|.|..|.||:||::
  Fly  1265 HLVEFGSPYELLTSSESKIFHGMVM 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	388/1321 (29%)
		ABC_membrane	328..560	CDD:294371	64/236 (27%)
		ABCC_MRP_domain1	621..827	CDD:213217	82/206 (40%)
		ABC_membrane	948..1192	CDD:279056	67/250 (27%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	86/221 (39%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	383/1311 (29%)
		ABC_membrane	93..359	CDD:294371	70/267 (26%)
		ABCC_MRP_domain1	422..622	CDD:213217	83/211 (39%)
		ABC_membrane	735..978	CDD:294371	67/278 (24%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	86/221 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870