Protein Alignment CG7806 and abcc2

DIOPT Version :9

• Sequence 1: NP_609207.1
• Gene: CG7806 / 34140
• FlyBaseID: FBgn0032018
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: NP_956883.2
• Gene: abcc2 / 393561
• ZFINID: ZDB-GENE-040426-1523
• Length: 1567
• Species: Danio rerio
• Alignment Length: 1675
• Identity: 475/1675 - (28%)
• Similarity: 770/1675 - (45%)
• Gaps: 321/1675 - (19%)

  Fly     1 MSSVVD--WGDFAWNWTQFCPTGLKPFANETNDLLPCFQE-ILLQLPVYTLFAAISAYNFGNQSR 62
            |::.:|  .|...|| :.|       ...|..||..|.:. :|:.||:..|:.. |.::|
Zfish     1 MTAALDKYCGSVFWN-SSF-------LQREDPDLPVCVERTVLVWLPLAFLWIC-SPFHF----- 51

  Fly    63 HVVRNGLQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTA 127
                          |:| ....|..|.:.::...|     ..|.||:::|...:.|.      ..
Zfish    52 --------------RSF-CQKSAKAPASALYYCKQ-----VVAGLLLLTAVAELAVT------LG 90

  Fly   128 RQYGELS-----------HRGSLLINVVWLTVVVLDAVWLRTSRH----------FSWWPWSLAT 171
            ..:|..|           :...:|..|.|:.|::..    .:.||          |.:|   |..
Zfish    91 EDFGPSSDEDAQKNPAVLYTNPVLFAVSWIVVMLCQ----ESMRHRLMCVDSGSLFMFW---LLQ 148

  Fly   172 LVCDLLFGVTLIPKG-SAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHL------------ 223
            :||.:....||:.:. |...|.:||..:             .|..:.|....|
Zfish   149 VVCAVFQFQTLLREALSQGISDVPRFCL-------------FYISYGLQIIALVLSAIADVSPEA 200

  Fly   224 -----GHAQDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDL-------------PDAL---- 266
                 .:.:.:|...||..|:|...::.||....|.: ||::||             .|.:
Zfish   201 KKVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQ-EDMWDLNKNDSTHFICQTFEDVMAKEL 264

  Fly   267 -----NITRLSEKLH----------LALSQSQSL-----------------------------W- 286
                 |:.:...|..          ||...||.:                             |
Zfish   265 KKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWL 329

  Fly   287 -RALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLL-----RQDHADPNQVYYYALGLFGSTLL 345
             ..:.:.|........:.:|:.||..||.|.||..::     :..:|...  |.||:.|.....:
Zfish   330 VTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTG--YLYAVLLVLVAFV 392

  Fly   346 SAVCATHFDWRMAMVSMKMRVGVVNSIYRKAL----EARGLKESKP-DLLNLMSTDTDRIVNSCI 405
            .:|....:..|..::.||:|..::.::|:|||    ::|  |||.. :::||||.|..|. |...
Zfish   393 QSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSR--KESTAGEIVNLMSADAQRF-NDVT 454

  Fly   406 SF-HFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLS 469
            :| |..||.|.::..::..|:::||.:.|:|::...|::|||.|||.:...|....|..||:|:.
Zfish   455 NFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMK 519

  Fly   470 ATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTFG-- 532
            ...:.:.|.|.:|..|||..|..:::.:|::||:.:.|..||.::..:.::..|.|:.|.||.
Zfish   520 IVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVF 584

  Fly   533 VSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNP 597
            |||...|.|.|...:||::|..:|..||...|.:::.:::..||.||:::.:...:||.::..:
Zfish   585 VSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDLDTTTVTH- 648

  Fly   598 IMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPV 662
                            |:...:.:.|...::..:.|  |.|.   :|.:::|||.|:||.:.|.|
Zfish   649 ----------------DSSITAAVSMTNGTYAWERD--TEPV---LKRVSLDIKPGRLVAVVGAV 692

  Fly   663 GGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLH 727
            |.||:|.:||::..|....|.:   .:.....||||..|:|..|::|||::|:..||:.|::|:.
Zfish   693 GSGKTSLVSALLGELHSIKGNI---NINGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIK 754

  Fly   728 ACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHII 791
            ||||..||.:| |.|...:||.|..|||||:.||:||||||....||||||.||::|:||.:|:.
Zfish   755 ACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLF 819

  Fly   792 KHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP--------------SEYM------ 834
            :..|  ..||:.||||::|..|....:.::|:.:..|.:..              ||::
Zfish   820 EKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETYGKD 884

  Fly   835 --------------------TQSIELSLDEDADDEQEPTV-----RRRSVELSNQYDK------- 867
                                .:::...|:..||...|..|     |..|:..|.::.|
Zfish   885 ESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKV 949

  Fly   868 --------------KSLDSLLLEELREYGHLSGNVFTCY-----WKAVTSPLAFTVLLSVVLMQL 913
                          |....|:.:|:.|.|.:..:|:..|     |..|.....|..:.:|.:  :
Zfish   950 RKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAV--I 1012

  Fly   914 TRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTL 978
            .:||   ||:.|          .|.|:::.       |:|...|.....:.:|.|:.::...:..
Zfish  1013 GQNL---WLSDW----------TDDSIEYF-------NQTYPNHIRDTRIGVFGALGLAQGFLVF 1057

  Fly   979 ARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLA 1043
            ....|.|...|.|:..:|..||..::.....|||.|..|||:|||:.|..|||:.:|......:.
Zfish  1058 FGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWIL 1122

  Fly  1044 QLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQG 1108
            .|.|::|.|.|...|.|....|::||..:|..:|:.|...||.::||.|.:.||:|:||.||:.|
Zfish  1123 CLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSG 1187

  Fly  1109 LTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTT 1173
            |:.||:.....||.:..:..:::::|:......:.:|||:||:.||.|:|..|.|.|.|:.. :.
Zfish  1188 LSVIRAYGHQDRFLKRNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRD-SL 1251

  Fly  1174 NPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEPPFGWPTQG 1238
            |.|||||.|||||::|..|..|:...:|.|..:|||||:.:|.:::.|.....|..||..||:.|
Zfish  1252 NSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAG 1316

  Fly  1239 VLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQV 1303
            .:.|.:.::.||..|...|.|:|...::.|:|||||||||||:|:...|.|:.....|.|.:|.:
Zfish  1317 NIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDI 1381

  Fly  1304 NLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDG 1368
            ::.||.|..||.|:.:|.|:|.||.||:|.||||...|.|:|||..::.:.....:.....||:.
Zfish  1382 DIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEH 1446

  Fly  1369 KVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAH 1433
            :|...|.|||.|||||||||||||:.::::.:||.|:.:|.|:|..||..:|..|..||:|.|||
Zfish  1447 EVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAH 1511

  Fly  1434 RLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQDIDPGEF 1483
            ||..:....|::|||.|:|.|..:|..|.|               .||.|
Zfish  1512 RLNTILDSSRVMVLDSGKIVEFDSPNELLS---------------KPGHF 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	471/1657 (28%)
		ABC_membrane	328..560	CDD:294371	74/239 (31%)
		ABCC_MRP_domain1	621..827	CDD:213217	83/208 (40%)
		ABC_membrane	948..1192	CDD:279056	84/243 (35%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	94/219 (43%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	473/1666 (28%)
		ABC_membrane	346..612	CDD:294371	83/270 (31%)
		ABCC_MRP_domain1	656..856	CDD:213217	83/207 (40%)
		ABC_membrane	1001..1270	CDD:279056	93/291 (32%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	94/219 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720