DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC6

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1609	Identity:	453/1609 - (28%)
Similarity:	727/1609 - (45%)	Gaps:	246/1609 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GDFAWNWTQFCPTGLKPFANETNDLLPCF----------QEILLQLPVYTLFAAISAYNFGNQSR 62
            |...||.|:       |....|:.|..||          ..:.:..|:|.||.           .
Human    10 GQGVWNQTE-------PEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFI-----------H 56

  Fly    63 HVVRNGLQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECI-MWVVHSGFLLT 126
            |..|..|::..|    |.|.::|.:|    .:.....|..||..:|..|:..: :|.:..| ...
Human    57 HHGRGYLRMSPL----FKAKMVAAIP----GSLEPGNVLGFALIVLCTSSVAVALWKIQQG-TPE 112

  Fly   127 ARQYGELSHRGSLLINVVWLTVVVLDAVWLRTSRH---------FSWWPWSLATLVCDLLFGVTL 182
            |.::        |:...||||.:......:.|.|.         |.:|      |:|.:|.....
Human   113 APEF--------LIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYW------LLCFVLPATNA 163

  Fly   183 IPKGS-AVYSSLP---------RSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFL 237
            ..:.| |.:.|.|         .|.|.|:.....|:.:..:|..|..:|: ...:..|...|:..
Human   164 AQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSN-PCPETGAAFPSKAT 227

  Fly   238 FHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLHLA------------------------ 278
            |.||..|:.:|....||. :||:.|....:...|..:|...
Human   228 FWWVSGLVWRGYRRPLRP-KDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSG 291

  Fly   279 ---------LSQSQSLWRALHRCFGVEF---YLIGILRL-IADLSGFAGPLLLGGLLRQDHADPN 330
                     |.|..|.||.|.:.....|   :|:|.|.| |:|:..|..|.|| .|..:...||.
Human   292 MKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLL-SLFLEFIGDPK 355

  Fly   331 ----QVYYYALGLFGSTLLSAVCATHFD----WRMAMVSMKMRVGVVNSIYRK--ALEARGLKES 385
                :.|..|:.:|    |||...|.|:    :|:.::.|::|..:...:|||  ||.:...|.|
Human   356 PPAWKGYLLAVLMF----LSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKAS 416

  Fly   386 K-PDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYL-LYLQLGAAFLAGVIFAALLIPINRW 448
            . .|::||:|.|..|:..|.:..:..| :|.......:: |:..||.:.|..:.....|:|:|.:
Human   417 AVGDVVNLVSVDVQRLTESVLYLNGLW-LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF 480

  Fly   449 LAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDA 513
            ::|:........|..||:|...|:..::.:|.||.:.||..|:.::.|:|.:||..|.....|.:
Human   481 ISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFS 545

  Fly   514 MCVYFWATTPVLMCLLTFGVSVLMG-NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSI 577
            :.:..:..:..|:.|:.|.|..|:. |.:.|...:.::.:|.:|.......|:.::.|::|.||.
Human   546 VSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSF 610

  Fly   578 KRVQQLMDVPNLDYSSYYNP--IMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTP 640
            .|:...:.:..:|      |  :...|.||.||.|.         :.:..|:|....:     :|
Human   611 DRLVTFLCLEEVD------PGVVDSSSSGSAAGKDC---------ITIHSATFAWSQE-----SP 655

  Fly   641 FRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRG 705
            ..:..||:.:..|.|:.:.||||.||||.|||::..|...:|.|.::   ....||||..|:|..
Human   656 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIE---GAVAYVPQEAWVQNT 717

  Fly   706 TIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQD 769
            ::.:|:.:|.:.|..|.:.||.||||:.|:... .|....:||.|..|||||:.|::||||||:.
Human   718 SVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRK 782

  Fly   770 KKVYLLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPSE 832
            ..||||||.|::|||||.:|:....|  ..||:..|||:||..:.:...|:.|:.:.:|.:....
Human   783 AAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMG 847

  Fly   833 YMTQSIELS------LD------EDADDEQEP---------TVRRRSVELSNQYDKKSL------ 870
            ...:.::..      ||      :..:.|.||         |...|..||..:...||:
Human   848 SYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT 912

  Fly   871 ----------------------DSLLLEELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQL 913
                                  ||:      :||.:...|...|.:||.:||....|...:..|:
Human   913 TSEAQTEVPLDDPDRAGWPAGKDSI------QYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQV 971

  Fly   914 TRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYL--SIFTAIAVSNSLV 976
            .......||:.|..:                  |.||     |..|:..|  .||..:....::.
Human   972 ASFCRGYWLSLWADD------------------PAVG-----GQQTQAALRGGIFGLLGCLQAIG 1013

  Fly   977 TLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNIL 1041
            ..|........|.:|:..:.::||..|:.:..:||:.|.:|.:|||||.:|:|||..:|..|..|
Human  1014 LFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSL 1078

  Fly  1042 LAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETL 1106
            |....||:....|...|.|...:.|:|:..:|...|..|..:|..::||.|.:.|.:.:|..||.
Human  1079 LMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETF 1143

  Fly  1107 QGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASH 1171
            ||.|.:|:.|....|......:::||.:....:..|.:|||..::|||..||..|...|.::.:|
Human  1144 QGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAH 1208

  Fly  1172 TTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEE---QNASGSAEPPFG 1233
             .:.||||..:|.||.:|..|..::....:.|..:|:|||:..|....:|   :..:.:|:||
Human  1209 -LSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP-- 1270

  Fly  1234 WPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEI 1298
            ||..|.:.||:..|.||..|..|::|::|:..|.|::||||||||||:|:.:.|||:.....|.|
Human  1271 WPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGI 1335

  Fly  1299 RLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQL 1363
            .:|.|.:..:.|..||.||.:|.|:|.||.|::|.|||......|..||.|::......|:....
Human  1336 WIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLP 1400

  Fly  1364 GGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTL 1428
            |.|..|....|.:||.||:||||||||||:..:::.:||.|:.:|..::|.:|..|.:.|..||:
Human  1401 GQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTV 1465

  Fly  1429 LFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            |.||||||.:....|::|:|.|::.|.|:|..|.:... :||  .|||:
Human  1466 LLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKG-LFY--RLAQE 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	450/1602 (28%)
		ABC_membrane	328..560	CDD:294371	63/244 (26%)
		ABCC_MRP_domain1	621..827	CDD:213217	77/208 (37%)
		ABC_membrane	948..1192	CDD:279056	76/245 (31%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	91/219 (42%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	452/1605 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720