DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Sur

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2228	Identity:	474/2228 - (21%)
Similarity:	773/2228 - (34%)	Gaps:	841/2228 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FQEILLQLPVYTLFAAISAYNFGNQSRHVVRNG---LQLRMLSIRTFLAMVLALLPVAKVFAFHQ 97
            |..|.|.|  :.|....|.|...:::.....||   :.|.:|::.:|        .:|::|..||
  Fly    40 FFSIFLLL--FGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSF--------DLARIFLPHQ 94

  Fly    98 QG---VELFAA---DL--LVVSAECIMWVVHSGFLLT--ARQYGELSHRGSLLINVVWLTVVVLD 152
            ..   ..||.:   ||  |||.....:|......|||  ...|..:..|....:.:...|.|...
  Fly    95 NVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEAL 159

  Fly   153 AVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQFD 217
            ...|.::..|....:.      |.|...|.:...||:..      ||....:||...:..|....
  Fly   160 TFALLSNELFELVRYE------DFLELQTCLVAMSAMCM------VSLAMLDGLTVYKECYHDDY 212

  Fly   218 LNE-SHLGHAQDEANLGSRFLFHWVQPLILKGVAGKLRKIEDL--FDLPDALN---------ITR 270
            |:: ..:|:....|...|:..|.|:.||:..|....| ::|||  ..|.|:..         .|.
  Fly   213 LDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPL-ELEDLGQMKLEDSARSHYDHFLYIYTE 276

  Fly   271 LSEKLHLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGL------LRQDHADP 329
            ..:|    .:.|.|||....:.....|.|.|||:|..||....|||.:..:      |....::|
  Fly   277 KKKK----SNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEP 337

  Fly   330 ------NQVYYYALG-----------LFGS-------------------------TLLSAV---- 348
                  |:|....|.           :||:                         .||:|:
  Fly   338 PAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGA 402

  Fly   349 ---CATHFDWRMAMVSMKMRVGVVNSIYRKAL-----------EARGLKE--------------- 384
               .:||.   :.|..::::..:...||||:|           ::.|..:
  Fly   403 LSQASTHI---LNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDS 464

  Fly   385 ----------SKPD-------LLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLG-AA 431
                      |:|:       :.|.|:.||..|:...:..|:.|:||||:...:||||:.|| :|
  Fly   465 MATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISA 529

  Fly   432 FLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRG 496
            .:..:....::.|:..::...:...:..:....|.||....:|:.|.|.||:|||:::|:.||:.
  Fly   530 VIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQE 594

  Fly   497 LRQEELRFLSKRKYLDAMCVYFWA-------TTPVLMCLLTFGVSVLMGN----PLIASTTYTSV 550
            .|::||::|:|    ||.   ||.       ...||:..:|.||.|.:..    .|.||..::|:
  Fly   595 ARRKELKYLNK----DAT---FWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSL 652

  Fly   551 ALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLD- 614
            ||...|..||..||..:..:|.|.||.:|:::.:  .:.:....:..| |......:..||.||
  Fly   653 ALFQQLTVPLLIFPITVPIIIAARVSTRRLERFL--KSSEIQKQFEGI-RNMARILSKSDASLDM 714

  Fly   615 --APKASVLQMKCASF----------------------------CHDSDEQTSP----------- 638
              ..:.|.:.|:.|..                            ..:|.|..||
  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779

  Fly   639 ----------TPF------RMK--------------------------------DINVDIK---- 651
                      ||:      :|:                                ||.|.|.
  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLF 844

  Fly   652 ---------------------AGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGY 695
                                 .|:|..:.|..|.||:|.|||::..:....|.:...:..| ..|
  Fly   845 TWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCT-ISY 908

  Fly   696 VPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRAR 759
            |.|.|||...|||:||::|..|..:.|..||.||||:.|:::: .|||..:||.|..:|||||.|
  Fly   909 VSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQR 973

  Fly   760 VALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLK--HKTRIVVTRNIQLFFHANQILQ 822
            :|:|||:|....|.::||.|:|||..|..||.:|||..:|:  ::|.|:||:.:.....|..::.
  Fly   974 IAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIA 1038

  Fly   823 VKDGQL---------------LPSEY-------------------------------------MT 835
            :|||::               :.:|:                                     :.
  Fly  1039 IKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQ 1103

  Fly   836 QSIELSLDEDA------------------------DDEQ-------------------------- 850
            :||.:::|.:.                        :|:|
  Fly  1104 RSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYG 1168

  Fly   851 ----------------------------------------------------------------- 850

  Fly  1169 SRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLS 1233

  Fly   851 --------------------------EPTV----------------------------------- 854
                                      ||.|
  Fly  1234 RSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKS 1298

  Fly   855 --------------------------RRRSVELSN------------------------------ 863
                                      ||.|:..||
  Fly  1299 EEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPA 1363

  Fly   864 ------------QYDKK-----SLDS--------------------------------------- 872
                        |.::|     ::||
  Fly  1364 SILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVL 1428

  Fly   873 ----------------LLLEELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNLSDAW 921
                            |.::..|:||.:|.:::..|.:|...|:.....::.::.|..|..:|.|
  Fly  1429 AEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIW 1493

  Fly   922 LAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAY 986
            |..|     .:.|....|..|:::.|     :|..|...:|..::.||:....::.|.......|
  Fly  1494 LQQW-----SNVHGRVASKGHVVLHP-----SEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQY 1548

  Fly   987 AGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGA 1051
            ||..|...:|:|||:.::....:||.:|.:|||:||||:|...:|..:......||......:.|
  Fly  1549 AGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSA 1613

  Fly  1052 LCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMR 1116
            :.:::...||:.::.:|:...|..:|:.||.::|:::|:.:...||:.:|.:||:||:||||:..
  Fly  1614 ILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFN 1678

  Fly  1117 ASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITAS-----H---TT 1173
            ...||......:||.:..|....:.:.:||.:.|..||..:|..|.:.|...||     |   ||
  Fly  1679 QQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATT 1743

  Fly  1174 -------------------------NPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERID 1213
                                     :|.||||.|:|.|.:...|..::..:|:.|....:||||.
  Fly  1744 SPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIA 1808

  Fly  1214 QYLQLEE---------------------------------------------------------- 1220
            .|.|.::
  Fly  1809 HYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDG 1873

  Fly  1221 ---------------------EQNASGSA------------------------------------ 1228
                                 |..|..:|
  Fly  1874 DQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTS 1938

  Fly  1229 ----------------------EP----------PFGWPTQGVLSFREVQLSYREHLAPALRGIT 1261
                                  ||          |..||.:|.:.|..|.|.|.......:..:|
  Fly  1939 VIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLT 2003

  Fly  1262 FQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFL 1326
            .:..|.:||||.||||:||:|:..:|..|...|.|.|.:|.|:::.:....||.|:.:|.|:..|
  Fly  2004 LKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHL 2068

  Fly  1327 FEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLG-GLDGKVETCGNNLSAGQRQLLCLARA 1390
            |..|:||||||...|.|.::|:.::.:.....:...|. |||..:...|.|||||.|||||||||
  Fly  2069 FNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARA 2133

  Fly  1391 LLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEE 1455
            :|:.:..:.:||.||.||..::.::.:|...||:..|::.|||||..:...||:||||.|||.|:
  Fly  2134 ILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVED 2198

  Fly  1456 GNPQSLASDSSTIFYGML 1473
            |||:.|.....::|.|:|
  Fly  2199 GNPRELQQLEGSVFRGLL 2216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	472/2225 (21%)
		ABC_membrane	328..560	CDD:294371	75/335 (22%)
		ABCC_MRP_domain1	621..827	CDD:213217	84/320 (26%)
		ABC_membrane	948..1192	CDD:279056	75/276 (27%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	88/220 (40%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160