DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1437	Identity:	421/1437 - (29%)
Similarity:	665/1437 - (46%)	Gaps:	201/1437 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 GVTLIPKGSAVYSSLPRSGVSAREDEGLLS----QRYTYFQ-------FDLNESHLGHAQDEANL 232
            |:||.|:.:.          |..|||..|:    :|..|.|       |.:...| .|..|.|..
Zfish    14 GLTLSPQLTP----------SDPEDEVELAIETKRRGRYRQSLQILKPFRITHKH-QHPVDNAGF 67

  Fly   233 GSRFLFHWVQPLILKGVAGKLRKIEDLFDL----PDALNITRLSEKLHLAL--------SQSQSL 285
            .|.....|:.||..:.......|:||::.|    ....|..||....|..|        |.|:..
Zfish    68 FSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWLWHEELKRRGKDGASLSRVF 132

  Fly   286 WRALHRCFGVEFYLIGILR-LIADLSGFAGP-LLLGGLLRQDHADPNQVYYYALGLFGSTLLSAV 348
            ||     |.....|:.|.. ||..::||.|| ||:..||........::      |:|..|::.:
Zfish   133 WR-----FCQTRMLVAIFSLLITMVAGFVGPALLIRALLEFSQCSEVKL------LYGLALVAGI 186

  Fly   349 CATHF--DWRMAMV-------SMKMRVGVVNSIYRKALEARGLKE-SKPDLLNLMSTDTDRIVNS 403
            .....  .|.:|.:       :.::|...:...::|.|..|..|: |..:|:|:.::|..|:..:
Zfish   187 FLMELTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTKDVSSGELVNICASDGQRLYEA 251

  Fly   404 CISFHFFWSIPFKL------------FTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIF 456
            .       |:...|            :||.:     ||...|.|.....:..|.....::....|
Zfish   252 V-------SVGCLLAGGPLVGMLGLTYTTYF-----LGPTALVGSAIFIIFYPTMMLASRMTAYF 304

  Fly   457 SSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWAT 521
            ....:...|.|:....|.:...|.||:..||..|...|:.:|.||.|.|.....:.::.:.....
Zfish   305 RKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEERRNLEWAGCVQSLTLGVAPV 369

  Fly   522 TPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDV 586
            ..|:..:.||.:.:.:|..|.|:..:|.||:...:...|...|..:..|.|..|::||.|:|..:
Zfish   370 VVVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMTFALKVTPLAVRALSEGSVAVKRFQKLFMM 434

  Fly   587 PNLDYSSY-----YNPIMRGSGGSGAGDDAPLDAPKASVLQMK---------------------- 624
            .:.:..|.     || ::.....:.|.:.......|.|..|:|
Zfish   435 EDRELISVKTEDPYN-VVEFKDATLAWEKTCGSQTKKSRTQLKRGGMKRVLRREKLSLYIITEEN 498

  Fly   625 -------CASFCHDSDEQTSP-----------TPFR--MKDINVDIKAGQLVCIEGPVGGGKSSF 669
                   .|.......||.||           .|..  :..|::.|:.|.||.:.|.||.||||.
Zfish   499 KGKIEEPNAEHLLTHMEQESPQSTISSTQSIRPPLHKTLHRIDLCIQKGSLVGVCGGVGSGKSSL 563

  Fly   670 LSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEED 734
            |||::..:....|.|.|   ..||.||.|..|:...::|:||::|.:::|:.|..||.||.|..|
Zfish   564 LSALLGQMTLLGGSVSV---NGGFAYVAQQAWILNDSLRENILFGKKYNEEKYNAVLEACCLFPD 625

  Fly   735 -LQILGGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRL 798
             :::..||:..:||.|..||||||.||:||||:|.::.:.||||.||::||.|...:....|...
Zfish   626 IIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPILLLDDPLSAVDARVGSRLFHSAIRPA 690

  Fly   799 LKHKTRIVVTRNIQLFFHANQILQVKDGQLLPSEYMTQSIELSLD-------------------- 843
            .|.||.|.||..:|.....:.::.:||||:......||.:|...|
Zfish   691 AKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQLMEKGRDYAALFNSVQQENLVRKNLKN 755

  Fly   844 -EDADDEQEPTVRRRSVELSN----QYDKKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAFT 903
             |.|:.|..|    :::.:||    ..:.|..|.|:..|.:..|.::..|:..|.||...||||
Zfish   756 KEKAEKESSP----QTLHVSNPPKPDTESKKTDQLMQAEEKGSGAVAWPVYAAYIKAAGGPLAF- 815

  Fly   904 VLLSVVLMQLTRN---LSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTK----- 960
             :::::|...|..   .|:.||:||:.:.:     .::||       .:||||....:.:
Zfish   816 -IVTILLFLFTTGSIAFSNWWLSYWIRQGS-----GNSSL-------LLGNETAESDSMRLNPHI 867

  Fly   961 -FYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFS 1024
             :|..::.....:...:...|..:|....::||..:|:||.|.::.:...|||.|.:||||||||
Zfish   868 QYYSRVYVLSMGAALFLKTIRGLVFVKCTVRAASVLHDKLFKTLLLSPMRFFDTTPLGRILNRFS 932

  Fly  1025 SDTNTVDDSLPFILNILLAQLA------GLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHA 1083
            .|.:.||..|.....:||..:.      |:|||:      .||....|||:......:.:..|..
Zfish   933 KDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAV------FPWFLFSIIPLGAFLFIVNRISRVL 991

  Fly  1084 SRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLAL 1148
            .|::|||.:.:.||..:|.|.:||||:||.:......|...:|..|:.:...|...|.|.:|||:
Zfish   992 IRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQACQFLFSCAMRWLAV 1056

  Fly  1149 RLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERID 1213
            ||.|:...|:....||..:...| .:|...||.:|||:.:||.....:..::|||....:||||:
Zfish  1057 RLDLISISLITTVALLIVLMHGH-ISPAYAGLALSYAVQLTGLFQFTVRLLSETEARFTSVERIN 1120

  Fly  1214 QYLQ-LEEE--QNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGR 1275
            .|:: ||.|  :..:|.......||.:|.::|::|::.||:.|...|:.:.|.....|.||||||
Zfish  1121 HYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDGLPLVLKNLCFSILPEETIGIVGR 1185

  Fly  1276 TGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHG 1340
            ||:||:|:..||.|:|.|:.|.|.:|.||:..:.|..||.::.||.|||.||.||||.||||...
Zfish  1186 TGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVIPQEPVLFIGTVRSNLDPWDQ 1250

  Fly  1341 FYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTS 1405
            :.|::||.|::.:....::.|....|..:|...|.|.|.|:|||||:|||||:::|::.:||.|:
Zfish  1251 YTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLLCVARALLRHSKILLLDEATA 1315

  Fly  1406 NLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFY 1470
            .:|.|:|..||..:|::|..||.|.|||||..:...:||:|||.|:|.|...|.:|.:|.::.|:
Zfish  1316 AIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQGQILEFDTPSNLLTDENSRFH 1380

  Fly  1471 GMLLAQD 1477
            .|:.|.:
Zfish  1381 AMMEAAE 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	419/1430 (29%)
		ABC_membrane	328..560	CDD:294371	49/253 (19%)
		ABCC_MRP_domain1	621..827	CDD:213217	81/248 (33%)
		ABC_membrane	948..1192	CDD:279056	79/255 (31%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	96/219 (44%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	405/1376 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910