DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcc10

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1511	Identity:	573/1511 - (37%)
Similarity:	857/1511 - (56%)	Gaps:	130/1511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CFQEILLQLPVYTLFAAISAYNFGN-QSRHVVR---NGLQLRMLSIRTFLAMV---LALLPVAKV 92
            ||.:::|.:..:.|.|.:||.:.|. ::.::::   .|.:||:.:  :||..|   |.||||...
  Rat    28 CFTQLVLSVLPHALLAVLSACHLGTPRTNNIIQPFNPGWRLRLTA--SFLLSVFPLLDLLPVVLP 90

  Fly    93 FAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGELSH-RGSL-LINVVWLTVVVLDAVW 155
            ...|...:.|   ::|......:.|..|| ..|.|..:....| ||.| |....:|....|....
  Rat    91 PVSHPGPLWL---EVLAGCVTAVAWFTHS-LALWALVHSPHGHSRGPLALALAAFLPTPALVLTL 151

  Fly   156 LRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSA-----------REDEGLLSQ 209
            |        |.....|.:..||.|    |.|......|..:.|.|           ||.
  Rat   152 L--------WHCQRGTFLPPLLPG----PLGRVCLLILQLAAVLAYGLGWAAPGGPREP------ 198

  Fly   210 RYTYFQFDLNESHLGH-AQDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSE 273
             :|:..|...||.... |:|..:..|||.:.|:.||:.:||.|:||:.:|...||..|:...|:.
  Rat   199 -WTHDPFLSPESQEREVAEDGESWLSRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLAR 262

  Fly   274 KLHLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLG---GLLRQDHADPNQVYYY 335
            .......:...|||||:..||..:..:|:|:::..:.||:|||||.   |.|.:.....:....|
  Rat   263 AFQAHWKEGAQLWRALYGAFGCCYIALGLLKMVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLY 327

  Fly   336 ALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKESKP---DLLNLMSTDT 397
            .|||...:::|||....:.:.:..|:::.||.|::.:|||.|:   |..|:|   ::|||:.||:
  Rat   328 VLGLASGSVISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLK---LGPSRPPTGEVLNLLGTDS 389

  Fly   398 DRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMT 462
            :|::|...|||..|.:|.:|..||||||.|:|.|||||::.|.||:|:|:.:|.||...:..::.
  Rat   390 ERLLNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLR 454

  Fly   463 AKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMC 527
            .||||:...||.:.|.:.:|...||.....:::..|.:||..|...|||||.|||.||..||::|
  Rat   455 HKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVIC 519

  Fly   528 LLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYS 592
            ::.|...||:|:.|.|:..:|::||::|||.|||.||||:|||:|:.||:.|:|:.:|:|:....
  Rat   520 IVIFITYVLLGHQLTATKVFTALALVHMLILPLNNFPWVINGLLESKVSLDRIQRFLDLPSYSPE 584

  Fly   593 SYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDI--NVDIKAGQL 655
            :||:|            |.|.:  .::||::..|.|..|      ||....|..  ::.:|.|.|
  Rat   585 AYYSP------------DPPTE--PSTVLELHEALFSWD------PTGTSQKTFISHLQVKKGML 629

  Fly   656 VCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQ 720
            |.|.|.||.||||.|:||...|....|.|.|.:|:.|||...|.||:|..|||||:::|..||.|
  Rat   630 VGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQ 694

  Fly   721 WYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDA 784
            .|:.||.||||.:||.|| .||...|||.|.|||||||||:||||||||:|.:|||||.|:::||
  Rat   695 LYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDA 759

  Fly   785 HVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLL----PSEY--MTQSIELSL- 842
            .||.|::..|||.:|.|.||::.|...:....|:.:|.::.|:|:    |||.  :.|:...:|
  Rat   760 DVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILPLVQAAPTALA 824

  Fly   843 --DEDADDEQEPTVRRRSVELSNQYD--KKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAFT 903
              ::..|..|.|:|.... :.:.:.|  :.:...|:.||.:..|.::.:|:..||:|:.|.||..
  Rat   825 DKEQVTDSGQSPSVHNLE-KTTEELDVAQNTSGRLVQEESKSEGAVALHVYRAYWRAMGSGLATA 888

  Fly   904 VLLSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDT---------------SLDHILMRPTVGN-- 951
            :|:|::|||.|||.:|.|||:|:::  |...:|.:               |...:|..|  ||
  Rat   889 ILISLLLMQATRNGADWWLAHWLSQ--LKAGRNSSEERPASSSPRSMGFFSPRLLLFSP--GNLY 949

  Fly   952 -----ETESGHT-TKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNF 1010
                 .|.:|.: ..|||:::..||..|||.||.||.|||...::||..:|.:||.:::.|...|
  Rat   950 IPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTF 1014

  Fly  1011 FDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLS 1075
            :|.|..||:|||||||...|||||||:||||||...||:|.|.|....:|||.|::.|:..||..
  Rat  1015 YDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFIYYG 1079

  Fly  1076 LQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQS 1140
            :|:|||.:.|:::||.|..:||||:|..:||.||..:|:..|:.||:.:.|..||.:.:.|....
  Rat  1080 VQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASY 1144

  Fly  1141 AAQQWLALRLQLLGTLLVGG-AGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQ 1204
            |..|||.:||||:|..:|.. ||:..........|||||||.:|||||:||.|..|:.:..:||.
  Rat  1145 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEA 1209

  Fly  1205 ELVAVERIDQY-LQLEEEQNASGSAEPP------FGWPTQGVLSFREVQLSYREHLAPALRGITF 1262
            .:|:|||:::| ..:.:|.:    .:||      ..|.|||.:.|::|.|.||..|..||.|:||
  Rat  1210 MMVSVERLEEYSCDIPQEPH----GQPPQSPHQRVSWLTQGSVEFQDVVLVYRPGLPNALDGVTF 1270

  Fly  1263 QTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLF 1327
            :.|..|::|||||||:||:|:...|.|:...:.|::.||.|:...|.|:.||.::.||.||||||
  Rat  1271 RVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLF 1335

  Fly  1328 EGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALL 1392
            .|||||||||:....|..:|.|::....:. :...:|||||::...|.:||.|||||||||||||
  Rat  1336 SGTVRENLDPQGLHEDRALWQALEQCHLSE-VAMAIGGLDGELGERGRDLSLGQRQLLCLARALL 1399

  Fly  1393 KNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGN 1457
            .:||::.|||.|:::|.::|..:||.:...|.:.|:|.|||||..:...||::||..||:.|..:
  Rat  1400 TDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDS 1464

  Fly  1458 PQSLASDSSTIFYGML 1473
            |.:|.:...::|..:|
  Rat  1465 PSALRNQPHSLFRQLL 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	572/1508 (38%)
		ABC_membrane	328..560	CDD:294371	91/234 (39%)
		ABCC_MRP_domain1	621..827	CDD:213217	99/208 (48%)
		ABC_membrane	948..1192	CDD:279056	113/252 (45%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	100/219 (46%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	522/1303 (40%)
		ABC_membrane	290..552	CDD:294371	102/264 (39%)
		ABCC_MRP_domain1	599..802	CDD:213217	99/208 (48%)
		ABC_membrane	957..1190	CDD:294371	104/232 (45%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	25/76 (33%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	100/219 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I2856
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H58616
Inparanoid	1	1.050	890	1.000	Inparanoid score	I368
OMA	1	1.010	-	-		QHG53842
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	1	1.000	-	-		oto95930
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	LDO	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5384
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840