DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcc5

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1359	Identity:	419/1359 - (30%)
Similarity:	677/1359 - (49%)	Gaps:	134/1359 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 HAQDEANLGSRFLFHWVQPLI-LKGVAGKLRKIEDLFDL----PDALNITRL----SEKLHLALS 280
            |..|.|.|.|...|.|:.||. :....|:| .:||::.|    ...:|..||    .|:|:....
Mouse    99 HPVDNAGLFSYMTFSWLSPLARVVHKKGEL-LMEDVWPLSKYESSDVNSRRLERLWQEELNEVGP 162

  Fly   281 QSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGP-LLLGGLLRQDHADPNQVYYYALGLFGSTL 344
            .:.||.|.:.........|..:..:|..|:||:|| .::..||....|..:.:.|..|.:.|..|
Mouse   163 DAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFVVKHLLEYTQATESNLQYSLLLVLGLLL 227

  Fly   345 LSAVCATHFDWRMAM-------VSMKMRVGVVNSIYRKALEARGLKE-SKPDLLNLMSTDTDRIV 401
            ...|.:    |.:|:       ..:::|..::...::|.|:.:.:|| |..:|:|:.|.|..|:.
Mouse   228 TEVVRS----WSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMF 288

  Fly   402 NSCISFHFFWSIPFKLFTTLYLLY--LQLG-AAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTA 463
            .:..........|  :...|.::|  :.|| ..||...:| .|..|...::::....|....:.|
Mouse   289 EAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVF-ILFYPAMMFVSRLTAYFRRKCVAA 350

  Fly   464 KDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCL 528
            .|.|:....|.:...|.||:.||...|...::.:|:||.|.|.|..|..::.|.......|:..:
Mouse   351 TDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQSITVGVAPIVVVIASV 415

  Fly   529 LTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQ--LMD----VP 587
            :||.|.:.:|..|.|:..:|.|.:...:...|...|:.:..|.||.|::.|.:.  ||:    :.
Mouse   416 VTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK 480

  Fly   588 NLDYSSYY-----NPIMRGSGGSGAGDDAPLDAPK-----------------------ASVLQMK 624
            |...|.:.     |..:.......:..::|...||                       .:||..:
Mouse   481 NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRATRGKKEKSRQLQHTEHQAVLAEQ 545

  Fly   625 CASFCHDSDEQTSPTPFRMKDI------------NVD--IKAGQLVCIEGPVGGGKSSFLSAIVA 675
            ......||||:.||.....|.|            |:|  |:.|:||.|.|.||.||:|.:|||:.
Mouse   546 KGHLLLDSDERPSPEEEEGKQIHTGSLRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILG 610

  Fly   676 NLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-G 739
            .:...:|.:.|   :..|.||.|..|:...|:||||::|.:|||:.|.:||::|.|..||.|| .
Mouse   611 QMTLLEGSIAV---SGTFAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPN 672

  Fly   740 GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTR 804
            .||..:||.|..||||||.|::||||:|.|:.:|:|||.||:|||||..||....|.:.||.||.
Mouse   673 SDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTV 737

  Fly   805 IVVTRNIQLFFHANQILQVKDGQL-----------LPSEYMTQSIELSLDE----DADDEQEPTV 854
            :.||..:|.....::::.:|:|.:           |..:|.|....|.|.|    :.:.::|.|.
Mouse   738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEATG 802

  Fly   855 RRRSVE-------LSNQYDKKSLDSLLLE-ELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLM 911
            .::|.:       :..:...||.:..|:: |.:..|.:..:|:..|.:|...||||.|::.:.::
Mouse   803 SQKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFML 867

  Fly   912 QL-TRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSL 975
            .: :...|..||:||:.:.:    .|.|....  .|..|.:..:.....::|.||: |::::..|
Mouse   868 NVGSTAFSTWWLSYWIKQGS----GNSTVYQG--NRSFVSDSMKDNPFMQYYASIY-ALSMAVML 925

  Fly   976 VTLA-RAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLP---- 1035
            :..| |..:|....::|:..:|::|.::::.:...|||.|..||||||||.|.:.||..||
Mouse   926 ILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 990

  Fly  1036 -FILNILLAQLAGLVGALCVSLYA--MPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSP 1097
             ||.|::|.       ..||.:.|  .||..:.:.|::.::..|....|...|::|||.:...||
Mouse   991 MFIQNVILV-------FFCVGMIAGVFPWFLVAVGPLLILFSLLHIVSRVLIRELKRLDNITQSP 1048

  Fly  1098 LYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAG 1162
            ..:|.|.::|||.||.:......|...:|..|:::.......:.|.:|||:||.|:...|:...|
Mouse  1049 FLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTG 1113

  Fly  1163 LLAAITASHTTNP-GLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQY---LQLEEEQN 1223
            |:  |...|...| ...||.||||:.:||.....:...:|||....:||||:.|   |.||....
Mouse  1114 LM--IVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR 1176

  Fly  1224 ASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALL 1288
            ....| ||..||.:|.::|...::.|||:|...|:.::|..:..|:||||||||:||:|:..||.
Mouse  1177 IKNKA-PPHDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALF 1240

  Fly  1289 RVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNS 1353
            |:..|:.|.|::|.:.:..:.|:.||.::.:|.|||.||.||||.||||.:.:.:.:||.|::.:
Mouse  1241 RLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERT 1305

  Fly  1354 AAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQA 1418
            .....:.|....|:.:|...|:|.|.|:|||||:|||||::.|::.:||.|:.:|.|:||.||:.
Mouse  1306 HMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET 1370

  Fly  1419 LRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            :|.||..||:|.|||||..:...|||:||..|::.|...|..|.|:.|:.||.|..|.:
Mouse  1371 IREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAE 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	417/1352 (31%)
		ABC_membrane	328..560	CDD:294371	56/242 (23%)
		ABCC_MRP_domain1	621..827	CDD:213217	90/220 (41%)
		ABC_membrane	948..1192	CDD:279056	78/252 (31%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	92/219 (42%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	416/1351 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		13/67 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720