DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcc9

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1618	Identity:	450/1618 - (27%)
Similarity:	755/1618 - (46%)	Gaps:	238/1618 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FCPTGLKPFANETNDLL--PCFQEILLQLP-VYTLFAA--ISAYNFGNQSRHVVRN--------G 68
            ||...:..: |..:.:|  |||.:.|..:| |:.||..  |....:|:||..|..:        |
  Rat     5 FCGNNISSY-NIYHGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPG 68

  Fly    69 LQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYG-- 131
            ..||.  |.||..:.:.:..:|:......|.    |:..|.:....:|     ||:.|.....
  Rat    69 HNLRW--ILTFALLFVHVCEIAEGIVSDSQR----ASRHLHLFMPAVM-----GFVATTTSIVYY 122

  Fly   132 ---ELSHRGSLLIN--VVWLTVVVLDAVWLRTSRHFSWWP--WSLATLVCDLLF---GVTLIPKG 186
               |.|:...||:.  :.|:...:     .:|.:...:|.  |.::    ||.|   ||.:|..|
  Rat   123 HNIETSNFPKLLLALFLYWVMAFI-----TKTIKLVKYWQLGWGMS----DLRFCITGVMVILNG 178

  Fly   187 SAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFL-----------FHW 240
            .          :.|.|...:..:||.:|   :|...:...:|..:||.|||           :.|
  Rat   179 L----------LMAVEINVIRVRRYVFF---MNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWW 230

  Fly   241 V---------QPLILKGVAGKL----RKIEDLFDLPDALNITRLSEKLHLALSQSQSLWRALHRC 292
            :         :|:.||.: |||    |.:.:...|.:|....:.....|  .:::.|:|.|::|.
  Rat   231 MNTLIISAHRKPIDLKAI-GKLPIAMRAVTNYVCLKEAYEEQKKKAADH--PNRTPSIWLAMYRA 292

  Fly   293 FGVEFYLIGILRLIADLSGFAGPLLLGGLLRQDHADPN----------------QVYYYALGLFG 341
            ||....|....|.:|||.||||||.:.|::::.:...|                ..:..|:.||.
  Rat   293 FGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEPKNNTTRFSETLSSKEFLENAHVLAVLLFL 357

  Fly   342 STLLS---------AVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKE-SKPDLLNLMSTD 396
            :.:|.         ....|..:.|.|:::|     :.|.|.|.:.....:.| :...:.||::.:
  Rat   358 ALILQRTFLQASYYVTIETGINLRGALLAM-----IYNKILRLSTSNLSMGEMTLGQINNLVAIE 417

  Fly   397 TDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLM 461
            |::::.........|::|.::...:.|||..||::.|.|.....||.||..::|.::.......:
  Rat   418 TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 482

  Fly   462 TAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLM 526
            .....||..|.|.::|.|.:|:.|||.||...:...|.:||..|.......::.::..|..|:..
  Rat   483 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAA 547

  Fly   527 CLLTFGV-SVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLD 590
            .|.||.. :...||.|..:..:.|::|.::|:.||.....|:...::|.:|::::.:.:
  Rat   548 VLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFL------ 606

  Fly   591 YSSYYNPIMRGSGGSGAGDDAPLDAPK------ASVLQMKCASFCH-DSDEQTSP-TPFRMKDI- 646
               ..:.|...|..:|.| ..|.::.|      :..:..|.....| |:.||... .|...:|:
  Rat   607 ---LSDEIGEDSWRTGEG-TLPFESCKKHTGVQSKPINRKQPGRYHLDNYEQARRLRPAETEDVA 667

  Fly   647 ------------------NVDIK--AGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVC---VQE 688
                              |:||:  .|||..|.|.||.||||.|.||:..:|..:|:|.   |.|
  Rat   668 IKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNE 732

  Fly   689 LTTGF-----------GYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQILG-GD 741
            ....|           .|..|.|||...|:.:||.:|:.|:.|.||.|..||:|:.|:.:|. ||
  Rat   733 SEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACSLQPDIDLLPFGD 797

  Fly   742 LVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLK--HKTR 804
            ...:||.|..||||||.|:.:|||:||:..:..|||..|:||.|::.|:::..||:.|:  .:|.
  Rat   798 QTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTV 862

  Fly   805 IVVTRNIQLFFHANQILQVKDGQLLP----SEYMTQSIEL-------------SLDEDADDEQ-- 850
            ::||..:|...||:.|:.:|||.:|.    .:..|:.:||             .|::|.:.:|
  Rat   863 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTT 927

  Fly   851 --EPTVRRRSVELSNQYDKKSLDSLLLEELREYGHLSGNVF---------TCYWKAVTSP--LAF 902
              ..|:||.......:...:..|....||..|..::| .|.         ||:|...:..  |.|
  Rat   928 LERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMS-TVMRLRTKMPWKTCWWYLTSGGFFLLF 991

  Fly   903 TVLLSVVLMQLTRNLSDAWLAYWVTETTL-DPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIF 966
            .::.|.:|........|.|||.|.:|.:: ||.|.|.:                     ||::.|
  Rat   992 LMIFSKLLKHSVIVAIDYWLATWTSEYSINDPGKADQT---------------------FYVAGF 1035

  Fly   967 TAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVD 1031
            :.:..:...:.|..:....:.|:.||..:|..||.|::.....|||.|.:|.||||||:|||.:|
  Rat  1036 SILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIID 1100

  Fly  1032 DSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMS 1096
            ..:|..|..|.......:.|:.:..||.|...:.:.|:...:..:|:.:|.||:|::.|..:...
  Rat  1101 QHIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQL 1165

  Fly  1097 PLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGA 1161
            ||..||:||.:||||||:.|...||::......:.:..|.|..|||.:||.:|...||..:|
  Rat  1166 PLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV--- 1227

  Fly  1162 GLLAAITA-SHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNAS 1225
             |.|:|.: |.::|.|||||.:.|||:||..|..::..:|:.|.::.||::::.:|.:|.| |..
  Rat  1228 -LTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYE 1290

  Fly  1226 GSAEP---PFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAAL 1287
            |:.:|   |..||.:|.:...::.:.|..:|.|.|:.:....:..:::||.||||:||:|:..|.
  Rat  1291 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1355

  Fly  1288 LRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKN 1352
            .|:..:..|:|.:|.:::..|||..||.|:.:|.|:|.||.|::|.||||.....|..:|.|::.
  Rat  1356 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1420

  Fly  1353 SAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQ 1417
            :....::....||||..|...|.|.|.|||||.|||||.::.:.::.:||.|:::|..::..:|:
  Rat  1421 AQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1485

  Fly  1418 ALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLA 1475
            .:..||...|::.||||:..:...|.:||:..|.|.|...|:||.:....:|...:.|
  Rat  1486 VVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRA 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	449/1613 (28%)
		ABC_membrane	328..560	CDD:294371	57/258 (22%)
		ABCC_MRP_domain1	621..827	CDD:213217	86/245 (35%)
		ABC_membrane	948..1192	CDD:279056	81/244 (33%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	75/219 (34%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	391/1364 (29%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720