Protein Alignment CG7806 and Abcc8

DIOPT Version :9

• Sequence 1: NP_609207.1
• Gene: CG7806 / 34140
• FlyBaseID: FBgn0032018
• Length: 1487
• Species: Drosophila melanogaster
• Sequence 2: NP_037171.2
• Gene: Abcc8 / 25559
• RGDID: 3786
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 1628
• Identity: 457/1628 - (28%)
• Similarity: 739/1628 - (45%)
• Gaps: 260/1628 - (15%)

  Fly    35 CFQEILLQLP-VYTLFAA--ISAYNFGNQSR--HVVRN------GLQLRMLSIRTFLAMVLALLP 88
            ||.:.|..:| |:.||..  |....:|:||.  |:..:      |..||.  |.||:.:.:.:..
  Rat    26 CFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRW--ILTFILLFVLVCE 88

  Fly    89 VAK------------VFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGELSHRGSLLI 141
            :|:            :..:...|:...||...||....|                |.|:...|||
  Rat    89 IAEGILSDGVTESRHLHLYMPAGMAFMAAITSVVYYHNI----------------ETSNFPKLLI 137

  Fly   142 N--VVWLTVVVLDAV-WLRTSRH---FSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSA 200
            .  :.|....:...: :::...|   ||...:.|..|:. :|:|:.|:.:.:.:
  Rat   138 ALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLV-ILYGMLLLVEVNVI----------- 190

  Fly   201 REDEGLLSQRYTYFQF--------DLNESHLGHAQDEANLGSRFLFHWV---------QPLILKG 248
                  ..:||.:|:.        ||.:..:...|...||.|:..:.|:         :|:.|:.
  Rat   191 ------RVRRYVFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRA 249

  Fly   249 VAGKLRKIEDLFDLPDALNITRLSEKLHLAL-------SQSQ----SLWRALHRCFGVEFYLIGI 302
            : ||         ||.|:......::|.||.       :|||    ::||||...||....|...
  Rat   250 I-GK---------LPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSST 304

  Fly   303 LRLIADLSGFAGPLLLGGLL----RQDHA-DP----------------NQVYYYALGLFGSTLLS 346
            .|::|||.||||||.:.|::    :::|. .|                ...|..|:.||.:.||.
  Rat   305 FRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQ 369

  Fly   347 AVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGLKESKPD-----LLNLMSTDTDRIVNSCIS 406
            ........:......:.:|..:...||.|.:.......|..:     :.||::.||::::
  Rat   370 RTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLM----- 429

  Fly   407 FHFF-----WSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDA 466
            :.||     |::|.::...:.|||..||.:.|.|.....||.|:..::|.::.......:...:.
  Rat   430 WFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNE 494

  Fly   467 RLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTF 531
            ||..|.|.::|.|.:|:.|||:||.:::...|::|:..|.......::.::.....|:...|:||
  Rat   495 RLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITF 559

  Fly   532 --GVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNL--DYS 592
              .||....:....|..:.|::|.::|:.||.....|:...::|.||::::.:.:....:  :..
  Rat   560 VGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC 624

  Fly   593 SYYNPIMRGSGGSGAGDDAPLDAPK------------ASVLQMKCASFCHDSDE----------- 634
            :...|..:|..|....  .||....            ...||....|...|:|.
  Rat   625 APREPAPQGQAGKYQA--VPLKVVNRKRPAREEVRDLLGPLQRLTPSTDGDADNFCVQIIGGFFT 687

  Fly   635 ---QTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEV------------ 684
               ...||   :.:|.:.|..|||..|.|.||.||||.|.|.:..:|...|.|
  Rat   688 WTPDGIPT---LSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGE 749

  Fly   685 --CVQELTTG----------FGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQI 737
              ...|..|.          ..|..|.|||...|:.:||.:.:.|::|.||.|:.||:|:.|:.|
  Rat   750 DPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDI 814

  Fly   738 L-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLK- 800
            | .||...:||.|..||||||.|:::|||:||...|..|||..|:||.|::.|:::..||.||:
  Rat   815 LPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRD 879

  Fly   801 -HKTRIVVTRNIQLFFHANQILQVKDGQLLPSEYMT--QSIELSLDE---------DADDEQEPT 853
             .:|.::||..:|...||:.|:.:|||.:.....:.  |..|..|.|         |.:.|:|..
  Rat   880 DKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETV 944

  Fly   854 VRRRSVELSNQYDK--KSLDSLLLE---------ELREYGHLSGNVF---TCYWKAVTSPL--AF 902
            :.|::.|.|....:  .|.|.|||:         |..|..:||..:.   ...|:|.|..|  |.
  Rat   945 MERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAG 1009

  Fly   903 TVLLS-VVLMQLTRNL----SDAWLAYWV-TETTLDPHKNDTSLDHILMRPTVGNETESGHTTKF 961
            .:||| :|..||.:::    .|.|||.|. :...|.|...:.||..           |.......
  Rat  1010 ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQ-----------ECALDQSV 1063

  Fly   962 YLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSD 1026
            |..:||.:......:.|..:....:.|:|.|..:|..||.:::.|...||:.|.:|.||||||||
  Rat  1064 YAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSD 1128

  Fly  1027 TNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLS 1091
            .||:|..:|..|..|.......|.||.|..|..|...:.::|:..:...:|:.:|.||||:::|.
  Rat  1129 CNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLD 1193

  Fly  1092 SNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTL 1156
            .....||.:||.||::||||||:.|...|||:......:.:..|.|..:||.:||.:|::.:|..
  Rat  1194 DTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1258

  Fly  1157 LVGGAGLLAAITASHTT-----NPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYL 1216
            :|    |:||.|:...:     :.|||||.::|||.::..|..::..:|:.|.:|.||:||...|
  Rat  1259 VV----LIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLL 1319

  Fly  1217 QLEEEQNASGSAEP---PFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGA 1278
            :.|.| :..|...|   |..||.||.:..:.:.:.|...|.|.|:.:.......::|||.||||:
  Rat  1320 KTEAE-SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGS 1383

  Fly  1279 GKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYD 1343
            ||:|...|..|:..:..|.|.:|.:::..|||..||.|:.:|.|:|.||.||:|.||||.....|
  Rat  1384 GKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSD 1448

  Fly  1344 SEIWHAIKNSAAATLLVQQL-GGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNL 1407
            |.:|.|:: .|...|:|:.| ||||..:...|.|.|.|||||.|||||.::...:..:||.|:::
  Rat  1449 STLWEALE-IAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1512

  Fly  1408 DDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGM 1472
            |..::..:|:.:..||...|::.||||:..:.:.|.::||..|.|.|...|:.|.|...::|...
  Rat  1513 DMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASF 1577

  Fly  1473 LLA 1475
            :.|
  Rat  1578 VRA 1580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	456/1623 (28%)
		ABC_membrane	328..560	CDD:294371	56/259 (22%)
		ABCC_MRP_domain1	621..827	CDD:213217	85/246 (35%)
		ABC_membrane	948..1192	CDD:279056	81/248 (33%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	81/220 (37%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	412/1395 (30%)
		ABC_membrane	<375..590	CDD:279056	49/219 (22%)
		P-loop_NTPase	679..907	CDD:304359	80/230 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..768		2/26 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..962		5/22 (23%)
		ABC_membrane	1017..1295	CDD:279056	93/292 (32%)
		ABCC_SUR2	1343..1582	CDD:213255	86/239 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810