DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abc4

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1523	Identity:	412/1523 - (27%)
Similarity:	694/1523 - (45%)	Gaps:	180/1523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DFAWNWTQFCPTGL-KPFANETNDLLPCFQEILLQLPVYTLFAAISAYNFGNQSRHVVR------ 66
            ||:.:.....||.. :|:.||.    |.:.:..|:..:..|:..: .|.:..:|..|.:
pombe    28 DFSLSAISIFPTHYDQPYLNEA----PSWYKYSLESGLVCLYLYL-IYRWITRSFTVKQTVGSEF 87

  Fly    67 ------NGLQLRMLSIRTFLAMVLALLPVAKVF--AFHQQGVELFAADLLVVSAECIMWVVHSGF 123
                  :|:.|.:||| .||.|. |.:.|...|  ||....|::.   ||..|..  ::::||..
pombe    88 SGLRKAHGILLWLLSI-LFLGMT-AFMFVNDAFPTAFSDPPVKIC---LLAYSVH--LFLLHSLR 145

  Fly   124 LLTARQYGELSHRGSLLINVVWLTVV---------VLDAVWLRTSRHFSWWPWSLATLVCDLLFG 179
            ::..|....|.| .::|:|::.|..:         .:|...|.:...|.|:           .|.
pombe   146 MIYPRARPTLYH-AAVLLNLLLLPPIFHFYSYPFFFVDHPPLSSYSPFLWF-----------YFF 198

  Fly   180 VTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFLF----HW 240
            :|::  |:.:....||..             |..|..|      .:......:.|.|.|    .:
pombe   199 ITIV--GNFIPLFTPRVW-------------YPLFPED------NYQPSAEQVCSMFNFACSYGY 242

  Fly   241 VQPLILKGVAGKLR--KIEDLFDLPD-------ALNITRLSEKLHLALSQSQSLWRALHRCFGVE 296
            :.||:|   ..|.|  :::|...:||       .....|:         ::.||:..:|:.|..:
pombe   243 LNPLVL---TAKRRVVEVDDTPVIPDYDKNKAWTYRFERM---------KTPSLFITIHKIFWRQ 295

  Fly   297 FYLIGILRLIADLSGFAGPLLLGGLLRQ----DHADPNQVYYYALGLFGSTLLSAVCATHFDWRM 357
            ...:|:...:..:..|..|:.|..||:.    ..:..|.:.:..|.|.|..|.|..  |.|...|
pombe   296 ILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVNPLVWIVLLLTGPFLTSLF--TQFYLFM 358

  Fly   358 AMVSM-KMRVGVVNSIYRKALEARGLKESKPDLL-----NLMSTDTDRIVNSCISFHFFWSIPFK 416
            :...: :....:|..||.|.:.:|.::....|..     ||:|||.|.|.......|.....|.:
pombe   359 STRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDDIGEIREFIHIIVRAPVE 423

  Fly   417 LFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQI 481
            :..::|||...||.:...|:....|...:...|...:...:.....|.|:|:...:|.:|..:..
pombe   424 IAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRATDSRIELMSELLQSIRIT 488

  Fly   482 KINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTFGV-SVLMGNPLIAST 545
            |...||...:.:::..||.||....|...::........:.||.....||.| :.:||..:..|.
pombe   489 KFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPVFSMFATFVVFTTIMGQTITPSI 553

  Fly   546 TYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDD 610
            .:||::|...:....:...:::..:::.:|||.||...::.|  |.....|.|...|...|..:
pombe   554 AFTSISLFSFIRTQFSWIAYLMRQIVQIFVSIGRVSDFLNDP--DEVDPVNTIEDTSQEIGFFN- 615

  Fly   611 APLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVA 675
                   ||:..:          ...||..|.::|:|:.....:|..:.||.|.||||.:||::.
pombe   616 -------ASLTWV----------SNPSPGDFCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLG 663

  Fly   676 NLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQ-ILG 739
            .|....|...:.. :.|..||.|.|||:..||||||::...:.|:.||.|:.||.|..||| .:.
pombe   664 ELSLNKGSYNLPR-SKGVSYVSQVPWLRNATIRDNILFDYPYIEERYKKVIQACGLLTDLQSFVA 727

  Fly   740 GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI-LRLLKHKT 803
            .||..:||.|.||||||:.|:|||||||....:.|:|||.|:||.|.:..|.|||. ..|::::|
pombe   728 SDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRT 792

  Fly   804 RIVVTRNIQLFF-HANQILQVKDGQLLPSEYMTQSIELSLDEDADDEQEPTVRRRSVELSNQY-D 866
            .|:||.|:.||. .|..|:.||:|...|....:..:....::.|...:.......::.:.|:. |
pombe   793 VILVTHNVHLFMDSAAFIVTVKNGSAFPVTDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDD 857

  Fly   867 KKSLD----SLLLEELREYGHLSGNVFTCYWKAVTSPL-AFTVLLSVVLMQLTRNLSDAWLAYWV 926
            .::.|    .|:.||.|..|.:..:....|.|...|.. ...|||..|..|.|..|.|.|:|:|.
pombe   858 AEAADEKDGKLVEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILIDLWVAFWT 922

  Fly   927 TETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKA 991
            ..:...|..|:..                      :|.::..:.::.||:...|...:......|
pombe   923 NSSVNSPDVNNNK----------------------FLFVYGTMLLAYSLLDFLRTVSYDRGAWWA 965

  Fly   992 AIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLP----FILNILLAQLAGLVGAL 1052
            :..:|:.:|:.|.....::||.|..|||:|||:.|..::|.:|.    |.:|..|: :||  |.|
pombe   966 SRKLHDSMLESVFGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLS-VAG--GIL 1027

  Fly  1053 CVSLYAMP--WLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSM 1115
            .|| .|||  .:..||:.:...|..|  .|..|...:|||.|...||:::...|::.|::.||:.
pombe  1028 SVS-SAMPIFMIPAVIVCLAGYYFGL--LYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAF 1089

  Fly  1116 RASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGL 1180
            .....|::.|..:|:..::.|.|.....:|:|:|...:..|:...|||:|.:  ....:||:||.
pombe  1090 NRQTIFKQMFSERLDNLVRLQSTSYNLNRWVAVRTDGISGLVGAIAGLIALL--QKDLSPGVVGF 1152

  Fly  1181 CISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEPPFGWPTQGVLSFREV 1245
            .::.|:..:..:...:.:....:.|:.:.||:.:|.:|.:|...:.:.:.|..||.:|.:.|..|
pombe  1153 SLNQAVIFSSSVLLFVRSCNSLQAEMNSYERVLEYSKLPQEPAPTIAGQVPATWPKEGDIVFNHV 1217

  Fly  1246 QLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPL 1310
            .:||.......|:.:.......|::.:|||||:||:::...|||......|||.::....:::.|
pombe  1218 SVSYSAAGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNL 1282

  Fly  1311 SVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGG-------LDG 1368
            :.||:||..|.|:|.||.||||.||||.....|:.:..|:|.|.|:::::.....       ||.
pombe  1283 NALRQRISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDT 1347

  Fly  1369 KVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAH 1433
            .|.:.|:|.|.||:|:|.||||:::.:|::.:||.|:::||..|..||:.||.||...|:|.|||
pombe  1348 HVASEGSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAH 1412

  Fly  1434 RLRGLHAMDRIIVLDDGRICEEGNPQSL 1461
            ||:.:...|:::|||.|.:.|.|.|..|
pombe  1413 RLKTIVDYDKVMVLDKGVLVEYGPPAVL 1440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	412/1523 (27%)
		ABC_membrane	328..560	CDD:294371	56/238 (24%)
		ABCC_MRP_domain1	621..827	CDD:213217	83/208 (40%)
		ABC_membrane	948..1192	CDD:279056	66/249 (27%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	84/226 (37%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	359/1266 (28%)
		ABC_membrane	300..568	CDD:294371	62/269 (23%)
		ABCC_MRP_domain1	611..817	CDD:213217	86/224 (38%)
		ABC_membrane	901..1164	CDD:294371	78/292 (27%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	84/226 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	40	1.000	Domainoid score	I3729
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.800