DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Tap1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_114444.2	Gene:	Tap1 / 24811	RGDID:	3817	Length:	725	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	144/535 - (26%)
Similarity:	239/535 - (44%)	Gaps:	51/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 SGHTTKFYLSIFTAIAVSNS-----LVTLARAFL-FAYAGIKAAIF------MHEKLLKKVMFAK 1007
            :|..|.:.|...||.:.:.:     ::|:|...| ||..||.....      :|.::.:.|:..:
  Rat   185 TGRITDWILQDKTAPSFARNMWLMCILTVASTALEFAGDGIYNITMGHMHSRVHGEVFRAVLHQE 249

  Fly  1008 FNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPI 1072
            ..||.....|.|.:|.:.||:.|.:|:...||:.|..|...:..|...::...:|.:|.:..:|:
  Rat   250 TGFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPL 314

  Fly  1073 YLSLQQRYR--HASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEES--- 1132
            ...|.:|..  :.|..:|...|.|.|....  .|.|..:.|:||........:.|:.||||.
  Rat   315 LFLLPRRLGKVYQSLAVKVQESLAKSTQVA--LEALSAMPTVRSFANEEGEAQKFRQKLEEMKPL 377

  Fly  1133 IKAQLTQSAAQQW------LALRLQLL---GTLLVGGAGLLAAITASHTTNPGLVGLCISYALSI 1188
            .|.:......:.|      :.|::.:|   |.|:|.||          .::..||.. :.|.|..
  Rat   378 NKKEALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGA----------VSSGNLVSF-VLYQLQF 431

  Fly  1189 TGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREH- 1252
            |..:..||......::.:.|.|:|.:||........|||..|   ...:|::.|::|..:|..|
  Rat   432 TRAVEVLLSIYPSMQKSVGASEKIFEYLDRTPCSPLSGSLAP---LNMKGLVKFQDVSFAYPNHP 493

  Fly  1253 LAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERI 1317
            ....|:|:||.....:...:||..|:||::|.|.|..:...|.|::.||...|.......|..::
  Rat   494 NVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGELLVQYDHHYLHTQV 558

  Fly  1318 GVITQEPFLFEGTVRENLDPRHGFYDS----EIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLS 1378
            ..:.|||.||..:.|||:  .:|...:    ||......|.|...:.....|.|.:|...||.||
  Rat   559 AAVGQEPLLFGRSFRENI--AYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQLS 621

  Fly  1379 AGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNA--FKSCTLLFIAHRLRGLHAM 1441
            .||||.:.|||||::..:::.:|:.||.||..:.|.:|:.|..:  :.|.|:|.|..:|......
  Rat   622 GGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERA 686

  Fly  1442 DRIIVLDDGRICEEG 1456
            ..|:.|.:|.:||:|
  Rat   687 HHILFLKEGSVCEQG 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	144/535 (27%)
		ABC_membrane	328..560	CDD:294371
		ABCC_MRP_domain1	621..827	CDD:213217
		ABC_membrane	948..1192	CDD:279056	62/262 (24%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	71/226 (31%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	144/535 (27%)
		ABC_membrane	177..435	CDD:279056	62/262 (24%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	352..397		10/44 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	430..464		8/33 (24%)
		P-loop_NTPase	469..697	CDD:304359	71/232 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000