DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and mrp-8

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_499598.2	Gene:	mrp-8 / 190710	WormBaseID:	WBGene00003414	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1582	Identity:	442/1582 - (27%)
Similarity:	719/1582 - (45%)	Gaps:	302/1582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LLPCFQEIL------LQLPVY---------------TLFAAISAYNFGNQSRHVVRNGLQLRMLS 75
            |:|.|..|:      |:.|.|               .:|.|:    :.||:.|
Worm    35 LIPVFVRIIRDNEPKLRAPKYFWAHLILQVLLLVDNAVFGAL----YFNQTDH------------ 83

  Fly    76 IRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWV---------VHSGFLLTARQYG 131
                   .|.||...:|.::                |.|.:|.         :|..|.|
Worm    84 -------FLPLLRFLQVLSY----------------ANCCIWFSLLSKRLHSIHPSFCL------ 119

  Fly   132 ELSHRGSLLINVVWLTVVVLDAVWLRTSRHFSWWPWSLATLVCDLLF--GVT-----LIPKGSAV 189
                        ::|.::||.||             .:..||.:..|  |||     |:.:.:.:
Worm   120 ------------IFLILLVLKAV-------------QVLVLVFESTFDAGVTAEFVLLMAETALL 159

  Fly   190 YSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFLFHWVQPLILKGVAGKLR 254
            .||..|.|    |||..:.|.               .:::::..|:..|.|:.|||..|....|.
Worm   160 ASSTKRLG----EDEQKIEQT---------------PEEKSSFLSKIFFCWLNPLIRAGAKQPLT 205

  Fly   255 KIEDLFDLPDALNITRLSEKLHLALSQSQSLWRA-------------------LHRCFGVEFYLI 300
            . |.|.:    ||....||.|:       :.|||                   ..|........:
Worm   206 N-ESLHN----LNENATSEWLY-------TRWRAEFDKEKAGRKSGETSIVWPFIRIQRATIITL 258

  Fly   301 GILRLIADLSGFAGPLLLGGLLRQD----HADPNQVYYYALGLFGSTLLSAVCATHFDWRMAMVS 361
            .:.||.||:..:..|:||..|:  |    |..|     .:.|:..:.::.:...|....:...::
Worm   259 TLARLTADIVHYLNPILLKQLI--DYVSLHDQP-----LSFGIAIACIMFSCSTTRSLLQNYQIA 316

  Fly   362 MKMRVGVV------NSIYRKAL----EARGLKESKPDLLNLMSTDTDRIVNSCISFHFFWSIPFK 416
            ...|..|.      |:|..|.|    .||. ..:..::||..:.|.:.||:|.......||:||:
Worm   317 GMCRQAVYYQTVLSNAILHKILRLSPSARS-NRTAGEILNHAAVDIEIIVHSVPYLQNMWSVPFQ 380

  Fly   417 LFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQI 481
            :...:.:|.:.||.|.:|||....|.||:|...::.|.:.....|..||.|...:.|.:.|.|.:
Worm   381 VTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQQKQMKIKDERTKLSNEMLNGIKVV 445

  Fly   482 KINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTFGVSVLMG---NPLIA 543
            |:.|||:.|..:|..||.:|::.|.....|..:.....|.:|.|:.:.:|...||..   |.|..
Worm   446 KLYAWEESFEDQINRLRAKEVKMLRNVCILSRIVDVANAASPFLVAIGSFTCYVLWSPDENGLTP 510

  Fly   544 STTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAG 608
            |..:.::.:...|..|:.....::|.|::|.||.||::|.::...::..:
Worm   511 SVAFVALTIFNQLRQPMRMVANLINTLVQARVSNKRLRQFLNDEEMERKT--------------- 560

  Fly   609 DDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAI 673
                 :....:.:..|.||. :....|..|.   :||::..||.|||:.|.|.|||||||.|||:
Worm   561 -----EVALGNAIVFKNASL-NWKGPQNPPV---LKDLSATIKPGQLIAIVGSVGGGKSSLLSAV 616

  Fly   674 VANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQ-I 737
            :..:...||.|   ::.....||||..|:...||::||::|.:....:|..|:.:|.|:.|.: .
Worm   617 LDEMVLLDGRV---KVGGSIAYVPQHSWIFNKTIKENILFGNELSNYFYDQVVGSCQLKTDFRHF 678

  Fly   738 LGGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI--LRLLK 800
            ..|:...|||||.||||||:||::|||||||||.:|||||.||::||||.|.:....|  ..||:
Worm   679 QQGENTMVGENGITLSGGQKARISLARAVYQDKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLR 743

  Fly   801 HKTRIVVTRNIQLFFHANQILQVKDGQLL-------------PSEYMTQSIELSLDEDADDEQE- 851
            .|||::||.|:|...:.:.|..::|||::             |...:....|.|.::.||:|.|
Worm   744 SKTRVLVTHNLQYTKYVDTIYVIEDGQIVQHGSFEDIAYVDGPFGRLWSECENSDEDVADEEAES 808

  Fly   852 ------PTV------RRRSVELSNQYDKKSLDSLLLEELR----------------EYGHLSGNV 888
                  |.|      ...::|.|:|.|:  .:|...|:.|                :.|.:..:|
Worm   809 SEASVTPPVPVLENGDNGAIEKSSQIDR--TNSHFSEKSRKSEEKPQKVEKNVENVQLGRVKKSV 871

  Fly   889 FTCYWK--AVTSPLAFTVL----LSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRP 947
            :..|.|  .:.:..||.:.    .:|::|   |:|   ||:.|..|.........:|:|::
Worm   872 YQLYIKTMGIFNSSAFLIFFIAHFTVMIM---RSL---WLSDWSNENAAIKKATLSSVDYL---- 926

  Fly   948 TVGNETESGHTTKFYLSIFTAIAV-----SNSLVTLARAF-LFAYAGIKAAIFMHEKLLKKVMFA 1006
               |.|.|   ....:|:.|.:.|     ...::.||.|| :.....::|:..:|..|:..::.|
Worm   927 ---NSTSS---VDGPVSVETRLIVYAGFGGLEMLLLALAFTVLTIGSLRASYGLHSPLIHALLVA 985

  Fly  1007 KFNFFDITSVGRILNRFSSDTNTVD---DSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIP 1068
            ..:|||.|..|||:||.|.|.:.:|   |::......||.....||   .:|: :.|...:...|
Worm   986 PISFFDTTPTGRIINRLSRDLDVIDKLQDNIRMCTQTLLNACMILV---LISI-STPIFLVCAAP 1046

  Fly  1069 MVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESI 1133
            ::.||..:...|...||.:|||.|...||:.:...|::.|.::||:...:.|........:::..
Worm  1047 LILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHGASSIRAFDKTERTTTALSTNVDKFA 1111

  Fly  1134 KAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTT-----NPGLVGLCISYALSITGQLG 1193
            :.:.....:.:|||.||:|||...|    |.|:::|:.:|     .||:.||.:||||:||..|.
Worm  1112 QCRYLSHMSNRWLATRLELLGNTCV----LFASLSATLSTKYFGLTPGMAGLSVSYALTITEVLN 1172

  Fly  1194 DLLHAVAETEQELVAVERIDQYLQLEEEQ--NASGSAEPPFGWPTQGVLSFREVQLSYREHLAPA 1256
            ..:.:|:|.|..:|:|||:::|.:||.|.  ....|.|....||.:|.:......:.||::|...
Worm  1173 ICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLENEEKWPVKGKIELDGFSMRYRKNLPLV 1237

  Fly  1257 LRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVIT 1321
            |:.|..:.|..||||::||||:||:|:..||.|:.....|.|::|.|.:.|:.|..||.::.:|.
Worm  1238 LKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIEGESGTIKIDDVEIDTIGLHQLRSKLIIIP 1302

  Fly  1322 QEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLC 1386
            |||.:|.||:|.||||.:.:.|.:||:.::.........:....||..:...|.|:|.|:|||||
Worm  1303 QEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQEDDKTLDRYIAEGGKNMSVGERQLLC 1367

  Fly  1387 LARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGR 1451
            |.||||:.|::|.:||.|:::|..:|..:|:|:|..|...|.:.|||||..:...|||:|||.||
Worm  1368 LCRALLRGARIVILDEATASVDTVTDGIVQRAIRQHFPQSTTISIAHRLDTIVDSDRIVVLDAGR 1432

  Fly  1452 ICEEGNPQSLASDSSTIFYGML 1473
            :.|...|.:|..:..:::..:|
Worm  1433 VAEFDTPSNLLLNPDSLYSQLL 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	441/1579 (28%)
		ABC_membrane	328..560	CDD:294371	61/244 (25%)
		ABCC_MRP_domain1	621..827	CDD:213217	89/208 (43%)
		ABC_membrane	948..1192	CDD:279056	73/257 (28%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	86/219 (39%)
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	401/1370 (29%)
		ABC_membrane	259..527	CDD:294371	71/275 (26%)
		ABCC_MRP_domain1	568..770	CDD:213217	89/208 (43%)
		ABC_membrane	887..1168	CDD:294371	82/304 (27%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	86/219 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710