DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcb1a

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_035206.2	Gene:	Abcb1a / 18671	MGIID:	97570	Length:	1276	Species:	Mus musculus

Alignment Length:	1371	Identity:	307/1371 - (22%)
Similarity:	537/1371 - (39%)	Gaps:	340/1371 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 FYLIGILRLIADLSGFAGPLLL-------------GGLLR----QDHADPNQVY----------- 333
            :.|:|.|..|  :.|.|.||::             |.:.:    ...||...::
Mouse    49 YMLVGTLAAI--IHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYA 111

  Fly   334 YYALGLFGSTLLSAVCATHFDWRMAMVSM--KMRVGVVNSIYRKAL---EARGLKESKPDLLNLM 393
            ||..|:....|:.|.....| |.:|....  |:|....::|..:.:   :...:.|     ||..
Mouse   112 YYYTGIGAGVLIVAYIQVSF-WCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGE-----LNTR 170

  Fly   394 STDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVI--------FAALLIPINRWLA 450
            .||....:|..|.....             ::.|..|.|..|.|        ...:::.|:..|.
Mouse   171 LTDDVSKINEGIGDKIG-------------MFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLG 222

  Fly   451 KRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIR------GLRQEELRF---LS 506
            ...||::..|.:..|..|.|..:....|:::         :..||      |.::|..|:   |.
Mouse   223 LSAGIWAKILSSFTDKELHAYAKAGAVAEEV---------LAAIRTVIAFGGQKKELERYNNNLE 278

  Fly   507 KRKYL---DAMCVYFWATTPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGP-LNAFPWVL 567
            :.|.|   .|:..........|:...::.::...|..|:.|..|:        ||. |..|..||
Mouse   279 EAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYS--------IGQVLTVFFSVL 335

  Fly   568 NGL---------IEAWVSIK----RVQQLMD-VPNLD---YSSYYNPIMRGSGGSGAGDDAPLDA 615
            .|.         |||:.:.:    .|.:::| .|::|   .|.:....::|:
Mouse   336 IGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGN------------- 387

  Fly   616 PKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCT 680
                 |:.|...|.:.|.::..    .:|.:|:.:|:||.|.:.|..|.|||:.:..:.......
Mouse   388 -----LEFKNIHFSYPSRKEVQ----ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPL 443

  Fly   681 DGEVCV--QELTT--------GFGYVPQSPWLQRGTIRDNIVWGAQ---FDEQWYKTVLHACALE 732
            ||.|.:  |::.|        ..|.|.|.|.|...||.:||.:|.:   .|| ..|.|..|.|.:
Mouse   444 DGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDE-IEKAVKEANAYD 507

  Fly   733 EDLQILGGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILR 797
            ..:::.......|||.|..|||||:.|:|:|||:.::.|:.|||:..|:||.. :..:::..:.:
Mouse   508 FIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVVQAALDK 571

  Fly   798 LLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPSE----------------YMTQS----IEL-- 840
            ..:.:|.||:...:....:|: ::...||.::..:                .|||:    |||
Mouse   572 AREGRTTIVIAHRLSTVRNAD-VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGN 635

  Fly   841 ----------SLDEDADDEQEPTVRRRSVELS--NQYD-------KKSLDS---------LLLEE 877
                      :||..:.|.....:||||...|  ..:|       |::||.         :|...
Mouse   636 EACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLN 700

  Fly   878 LREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDH 942
            ..|:.:....:|.........| ||:|:.|.|:...|..               .|
Mouse   701 STEWPYFVVGIFCAIINGGLQP-AFSVIFSKVVGVFTNG---------------GP--------- 740

  Fly   943 ILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAK 1007
                    .||:..::..|.| :|..:.:.:.:....:.|.|..||        |.|.|::.:..
Mouse   741 --------PETQRQNSNLFSL-LFLILGIISFITFFLQGFTFGKAG--------EILTKRLRYMV 788

  Fly  1008 F--------NFFD--ITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSL---YAM 1059
            |        ::||  ..:.|.:..|.::|...|..:....|.::...:|.|...:.:||   :.:
Mouse   789 FKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQL 853

  Fly  1060 PWLGLVIIPMVPI--YLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQ 1122
            ..|.|.|:|::.|  .:.::.....|.:|.|.|..:....     ||.::...|:.|:....:|:
Mouse   854 TLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA-----TEAIENFRTVVSLTREQKFE 913

  Fly  1123 ----RDFQVKLEESIKAQ----LTQSAAQQWL-------------ALRLQLL---GTLLVGGAGL 1163
                :..|:....::|..    :|.|..|..:             .:..||:   ..|||..|.:
Mouse   914 TMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIV 978

  Fly  1164 LAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVER---IDQYL-------QL 1218
            ..|:.         ||...|:|       .|...|.......:..:|:   ||.|.       .|
Mouse   979 FGAMA---------VGQVSSFA-------PDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNML 1027

  Fly  1219 EEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSV 1283
            |.....||..   |.:||:..:              |.|:|::.:.:..:.:.:||.:|.||::|
Mouse  1028 EGNVQFSGVV---FNYPTRPSI--------------PVLQGLSLEVKKGQTLALVGSSGCGKSTV 1075

  Fly  1284 LAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENL----DPRHGFYDS 1344
            :..|.|......|.:.||...:|.|.:..||.::|:::|||.||:.::.||:    :.|...|:
Mouse  1076 VQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYE- 1139

  Fly  1345 EIWHAIKNSAAATLLVQQLGGLDGKVET----CGNNLSAGQRQLLCLARALLKNAKVVAIDEGTS 1405
            ||..|.|.:.    :.|.:..|..|..|    .|..||.||:|.:.:||||::...::.:||.||
Mouse  1140 EIVRAAKEAN----IHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATS 1200

  Fly  1406 NLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFY 1470
            .||.||:..:|:||..|.:..|.:.|||||..:...|.|:|:.:|::.|.|..|.|.:... |::
Mouse  1201 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKG-IYF 1264

  Fly  1471 GMLLAQ 1476
            .|:..|
Mouse  1265 SMVSVQ 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	305/1365 (22%)
		ABC_membrane	328..560	CDD:294371	49/268 (18%)
		ABCC_MRP_domain1	621..827	CDD:213217	62/218 (28%)
		ABC_membrane	948..1192	CDD:279056	54/282 (19%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	70/227 (31%)
Abcb1a	NP_035206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PTZ00265	47..1263	CDD:240339	304/1362 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..681		9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000