DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and mrp-4

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_509658.1	Gene:	mrp-4 / 181202	WormBaseID:	WBGene00003410	Length:	1573	Species:	Caenorhabditis elegans

Alignment Length:	1641	Identity:	456/1641 - (27%)
Similarity:	726/1641 - (44%)	Gaps:	270/1641 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WGDFAWNWTQFCPTGLKPFANETNDLLPCFQE-ILLQLP---VYTLFAAISAYNFGNQSRHVV-R 66
            |....||            |:....|..|:|. .|:..|   |:.|...::|..|..:...:. .
Worm    21 WDPAVWN------------ASTVPILSQCYQHTTLVWFPTAIVFLLAPILTAQIFYRRPNPIPWT 73

  Fly    67 NGLQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYG 131
            ..:||::......:|..|:|..|| ::....||.. :|.|.:.....|:..||.:..:::.|.||
Worm    74 RRIQLKIGLACILIADSLSLFTVA-IYETLFQGFP-YAVDFVYPLTLCLAMVVLTALIVSCRNYG 136

  Fly   132 ELSHRGSLLIN------------VVWLTVVVLDAV---WLRTSRHFSWWPWSLAT-----LVCDL 176
            .:: .|.|.|:            :.|:..:|..|.   |:...|..:::.|....     |.|
Worm   137 IVT-SGGLFISWLVFTISAIPELLYWIQQIVNPAEAWNWIDYPRCIAFFIWFFCCAFETYLHC-- 198

  Fly   177 LFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFLFHWV 241
                         |:.....|             |.|.....|.|    .:..::..:|....|.
Worm   199 -------------YADASPEG-------------YKYLSAARNPS----PETTSSFLNRITMWWF 233

  Fly   242 QPLILKGVAGKLRKIEDLFDLPDA------------------------------------LNITR 270
            ..|...||...| ::.||:.|.:|                                    .|..|
Worm   234 NSLCSLGVKKPL-EVSDLYSLNEADTSNLLVPKWYNLWDKQSKKFEETAARRRIGSNASRTNRRR 297

  Fly   271 LSEKLHLALSQSQS-------------------LWRALHRCFGVEFYLIGILRLIADLSGFAGPL 316
            .|......|...||                   :| .|...|..:......::|::|:..|..||
Worm   298 TSSNDTTPLLNDQSTDDYGSVPAGQSTQKMPSIIW-TLFLMFKWDVITAMFVKLLSDVLLFCNPL 361

  Fly   317 LLGGLLR--QDHADPN-QVYYYALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKAL- 377
            ||..|:|  ::...|. |....|..:|.|..||::..:|:.:.|..|..:::..:..::|||.|
Worm   362 LLKSLIRFTEELERPMWQGVVLAFTMFFSAELSSILLSHYFYLMYRVGTRVQTCLTAAVYRKTLR 426

  Fly   378 --EARGLKESKPDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAA 440
              .|...:::..:::|||:.|.||..........:||.||::...|:||:.|||.:..:||....
Worm   427 LSNAARREKTVGEIVNLMAIDVDRFQQITPQTMQYWSNPFQIGLALFLLFQQLGVSVFSGVAVMV 491

  Fly   441 LLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFL 505
            ||.|||..:...|..:....|..||.|.....|.:.|.|.||:.|||......|..||::||..:
Worm   492 LLFPINFVITMIIRKWQIAQMYYKDERTKMVNEVLNGIKVIKLYAWEPPMEQVIEDLREQELGLI 556

  Fly   506 SKRKYLDAMCVYFWATTPVLMCLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVLN 568
            .|..:|..........:|.|:.|.||...:.:.  |.|.....:.|:.|...|..|::....::.
Worm   557 KKAAFLRTFSDMLNTASPFLVALSTFATFIYIDPKNVLTPEIAFVSLTLFNQLRSPMSQVAELIT 621

  Fly   569 GLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSD 633
            ..::..||.:|:::.:....|:..              |.|....|......|:..|.|: ..::
Worm   622 QTVQVVVSNRRLKEFLVSEELNVE--------------AIDHRARDNNDVICLKEACLSW-ESAE 671

  Fly   634 EQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQ 698
            .|..||   :.:|:..:..||||.|.|.||.||||.|.|::..::...|.:.:.....   ||||
Worm   672 HQPVPT---LTNISFSVNRGQLVTIVGRVGAGKSSMLQALMGEMEKLSGSISMHGRLC---YVPQ 730

  Fly   699 SPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENGRTLSGGQRARVAL 762
            .||:|..|:|.||.:|.||||.:|..||.||||..|||||. ||...:||.|..|||||:||::|
Worm   731 QPWMQNNTLRQNITFGKQFDEYFYSRVLDACALYRDLQILPLGDNTEIGEKGINLSGGQKARISL 795

  Fly   763 ARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKD 825
            ||||||:..:|||||.:|::||||...:....|  ..:|::||||:||..:.....::.|:.:.:
Worm   796 ARAVYQNHDIYLLDDPMSAVDAHVGSQLFGSVIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNE 860

  Fly   826 G------------------QLL----PSEYMTQSIELSLDEDADDEQEP---------------- 852
            |                  |||    ..|...:..|.|.||| |:..||
Worm   861 GKIEYSGKYDDLMQQGAFEQLLIECEKEERERREAEASADED-DENSEPGGIMIGGDSDFEYDDD 924

  Fly   853 ---------------------TVRRRSVELSNQYDKKSLDS-----------------LLLEELR 879
                                 .:.||.:..|....::.|.:                 |...|..
Worm   925 VMASPIIDHVLGTSHMSTVSGIINRRRISTSTHKQRRRLSTTKSHTHSITSASTQTRQLTGTERV 989

  Fly   880 EYGHLSGNVFTCYWKAVTSPLAFTVLLSV---VLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLD 941
            |.|.:..:.:..|:.|:...:|...:|.:   .:..:.|||   ||..|..:.......|.|
Worm   990 ETGRVKMDTYYKYFGAMGMSIAVLFVLGMTTSTIFSMGRNL---WLTDWSNDNAARSGSNTT--- 1048

  Fly   942 HILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFA 1006
                          |......|.::..:..|..::.........|.|:.|:..:|..|::.:...
Worm  1049 --------------GQPIAIRLGVYAGLGFSEIILLFIGMLSLLYGGVSASRNLHAPLMRNLFRV 1099

  Fly  1007 KFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVP 1071
            ...|:|.|..||||||...|..|||..|||.:......|..:|..|.:.:.:.|..|:||||:..
Worm  1100 PMAFYDTTPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFGIVIIPLSV 1164

  Fly  1072 IYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQ 1136
            :||.:.:.|...||.:|||.|...||:|:|.:|::||..|||:.....||.:..:.|::..::.:
Worm  1165 MYLMVMRYYIATSRQLKRLESITRSPIYSHLSESIQGSATIRAYHLVDRFCKLSETKVDSHVQCR 1229

  Fly  1137 LTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAE 1201
            .....|.:||::||:.:|..:|..:.|.||:|.: ||..|::||.:||||:||..|...:..:.:
Worm  1230 YLNYVANRWLSVRLEFIGNCIVLFSALFAALTRT-TTTSGVIGLSVSYALNITTVLNFAVRQITK 1293

  Fly  1202 TEQELVAVERIDQYLQLEEEQ--NASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQT 1264
            .|..:|:|||:.:|.:.|.|.  .:....|||..||::|.:........||..|...::.:..:.
Worm  1294 LETNIVSVERVKEYAETETEAEWKSEPGKEPPQNWPSEGRIVMNNYSARYRPGLNLVVKQLNVEI 1358

  Fly  1265 EAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEG 1329
            :..|::||||||||||:||..:|.|:.....|:|.:|.:||..:.|..||..:.:|.|:|.||.|
Worm  1359 KPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQIVVDGINLAEIGLHDLRSNLTIIPQDPVLFSG 1423

  Fly  1330 TVRENLDPRHGFYDSEIWHAIKNS---AAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARAL 1391
            |:|.||||.:.:.|.:||..::.:   ..||...:||..:   :...|:|:|.|||||:||||||
Worm  1424 TLRFNLDPFNHYSDGDIWKTLEMANLKEFATAHNEQLNYI---ITEGGDNISVGQRQLVCLARAL 1485

  Fly  1392 LKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEG 1456
            |:..:|:.:||.|:.:|..:|..||:.:|..|.:.|:|.|||||..:...||||||:||::.|..
Worm  1486 LRKTRVLILDEATAAVDVSTDALIQKTIREEFANATVLTIAHRLNTIMDYDRIIVLNDGKVGEFD 1550

  Fly  1457 NPQSLASDSSTIFYGM 1472
            :|.:|.|:.::.||.|
Worm  1551 SPANLLSNRNSEFYSM 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	455/1639 (28%)
		ABC_membrane	328..560	CDD:294371	68/237 (29%)
		ABCC_MRP_domain1	621..827	CDD:213217	89/226 (39%)
		ABC_membrane	948..1192	CDD:279056	77/243 (32%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	87/222 (39%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	456/1641 (28%)
		ABC_membrane	346..613	CDD:294371	77/266 (29%)
		ABCC_MRP_domain1	658..862	CDD:213217	88/210 (42%)
		ABC_membrane	1012..1259	CDD:294371	72/266 (27%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	87/222 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810