DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and mrp-1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1559	Identity:	456/1559 - (29%)
Similarity:	733/1559 - (47%)	Gaps:	206/1559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LFAAISAYNFGNQSRHVVR--NGLQLRMLSIRTFLAMVLALLPVAKVFAFHQQGVEL-------F 103
            :|:.|..|.........:|  :.:.||::    |..:::..|....::.|:....:.       |
Worm    49 IFSPILFYELYKSRNSYLRSFSAISLRII----FCCLLVVDLTATVIYDFYLLFTKSPLYNAIHF 109

  Fly   104 AADLLVVSAECIMWVVHSGFLLTARQYGELSHRGSLLINVVWLTVVVLDAVWLR---TSRHFSWW 165
            ..||:..:..|:..|:    .:..|..|.::   |.:|.:.||.|||.....||   |.|.:..:
Worm   110 YGDLVQYAGFCLALVL----TIACRNRGIIT---SGVITLYWLLVVVCGVPELRYYITGRLYKEY 167

  Fly   166 P-WSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDE 229
            . .|....:....:..:.:....:.::..|.:|...:..    ...||
Worm   168 EIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNS----CPEYT----------------- 211

  Fly   230 ANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPD---ALNI----------------TRLSEKL 275
            |:..::..|.|...|...|....|.| |||:||.:   |.||                .::.:..
Worm   212 ASFLNQLTFQWFSGLAYLGNKKSLEK-EDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNP 275

  Fly   276 HLALSQSQ-SLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLR--QDHADPNQV-YYYA 336
            ..|:.::. |:...:.:.:.......|..:|:.||..|..|.||..|:.  :|...|..: ...|
Worm   276 EAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIA 340

  Fly   337 LGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKAL----EARGLKESKPDLLNLMSTDT 397
            |.:|.|:||.::....:...|..:.|.:|..:.:::|.|.|    |||..|.:.. ::||||.|.
Worm   341 LLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGA-IVNLMSVDI 404

  Fly   398 DRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMT 462
            .||.:.......|||.|.::..:||.|:..||.:.|||.:...||||.|.:::.::.......|.
Worm   405 QRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMK 469

  Fly   463 AKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMC 527
            .||.|:...:|.:.|.|.:|:.:||......:..:|::|:|.|.|..||:|.....||..|.|:.
Worm   470 FKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVA 534

  Fly   528 LLTFGVSVLM---GNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNL 589
            :||||:.||.   .|.|....|:.::||..:|..||..|..|.:..::...|..|:::......:
Worm   535 VLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEM 599

  Fly   590 DYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQ 654
               |....|..|      |.|        |.::|...||...|.|:..    ::.||..:||.||
Worm   600 ---SPQTSIAYG------GTD--------SAIKMDGGSFAWGSKEEDR----KLHDITFNIKRGQ 643

  Fly   655 LVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDE 719
            ||.|.|.||.||||.|.|::..:....|.|   ::.....||||..|:|..::|:||::...:|.
Worm   644 LVAIVGRVGSGKSSLLHALLGEMNKLSGSV---QVNGSVAYVPQLAWIQNLSLRNNILFNRPYDA 705

  Fly   720 QWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLD 783
            :.|:.|:..|||.:||:.| ..|...:||.|..|||||:.||:|||||||:.::.||||.||::|
Worm   706 KLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVD 770

  Fly   784 AHVARHIIKHCI---LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP--------------S 831
            :||.:||.::.|   ...|..|||:::|..:....|.:|::.:||..:..              |
Worm   771 SHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFS 835

  Fly   832 EYMTQSI---------ELSLDEDAD---------DEQEPTVRRR-----SVELSNQYDK------ 867
            |::.:.:         .:|..||:.         |:..|.:|:|     |.|:....||
Worm   836 EFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIR 900

  Fly   868 -------------------------------------KSLDSLLLE-ELREYGHLSGNVFTCYWK 894
                                                 |...:.|:| |..|.|.:...|:..|::
Worm   901 NGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFR 965

  Fly   895 AVTSPLAFTVLLSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTT 959
            |:...:|....|..|...:....|:.:||.|          :|.:.:..|.    ||.:.|  .|
Worm   966 AIGIKIALVFFLVYVASSMLGVFSNLYLARW----------SDDAKEIALS----GNGSSS--ET 1014

  Fly   960 KFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFS 1024
            :..|.|:..:.:..:....|.:.:.|...:.|:..:|..||:.:|.:...|||:|.:|||||||.
Worm  1015 QIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFG 1079

  Fly  1025 SDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKR 1089
            .|.:.||..:|..:::.:......:..:.:.|:|.|....:::|:..:|..:.:.|...||.:||
Worm  1080 KDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKR 1144

  Fly  1090 LSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLG 1154
            |.|.:.||:|:||.|::||.::||:.....:|.|:.|.:::|::........|.:|||:||:::|
Worm  1145 LESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVG 1209

  Fly  1155 TLLV-GGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQL 1218
            .|:| ..||.......|...:.|||||.:||||:||..|...:...:|.|..:||||||::|...
Worm  1210 NLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTIT 1274

  Fly  1219 EEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSV 1283
            ..|.|.|.|..|. .||..|.:|.:...:.||..|...|.|:|......|:|||||||||||:|:
Worm  1275 PTEGNNSQSLAPK-SWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSL 1338

  Fly  1284 LAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWH 1348
            ..||.|:.....|.|.:|..|:..|.|..||.|:.::.|:|.||.||:|.||||...|.|.:||.
Worm  1339 TLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWE 1403

  Fly  1349 AIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDL 1413
            |::|:...:.:.....||...:...|.|||.|||||:|||||||:..||:.:||..:.:|.|:|.
Worm  1404 ALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDS 1468

  Fly  1414 SIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            .:|:.:|..||.||:|.|||||..:...||::|||.|.:.|...|:.|.|:...|||.|  |:|
Worm  1469 LLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSM--AKD 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	453/1552 (29%)
		ABC_membrane	328..560	CDD:294371	75/239 (31%)
		ABCC_MRP_domain1	621..827	CDD:213217	82/209 (39%)
		ABC_membrane	948..1192	CDD:279056	77/244 (32%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	94/219 (43%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	456/1559 (29%)
		ABC_membrane	309..570	CDD:294371	83/261 (32%)
		ABCC_MRP_domain1	614..815	CDD:213217	80/207 (39%)
		ABC_membrane	976..1248	CDD:279056	85/287 (30%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	94/219 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820