DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and mrp-7

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1615	Identity:	451/1615 - (27%)
Similarity:	717/1615 - (44%)	Gaps:	258/1615 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TQFCPTGLKPFANETNDLLPCFQE----------ILLQLPVYTLFAAISAYNFGNQ--SRHVVRN 67
            :.||..| .||:....::..|.|.          .||.||..:....::|..|...  |.|.:..
Worm     3 SSFCGDG-HPFSTGLPNVSICAQHTVLVWVPAAFFLLTLPFLSAQCHLTAQRFARLPFSAHFIIK 66

  Fly    68 GLQLRMLSIRTFLAMVLALLP----VAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTAR 128
            .|.:..|:..:.......|..    .|..:.:....|.::....||........:|.||
Worm    67 LLLVAFLAANSLATWCYVLFSKNSYAAAYYVYPGLWVLVWTGTFLVHLIRLRCGLVSSG------ 125

  Fly   129 QYGELSHRGSLLINVV-------WL----------TVVVLDAVWLRTSRHFSWWPWSLATLVCDL 176
                :.|..||:..:.       |:          .:...|:....:..:.||:. :|......|
Worm   126 ----IQHVTSLIFLLCGAPEFYQWIRMENSNSFPNDLTTTDSAQFLSIAYLSWYS-ALILYTFSL 185

  Fly   177 LFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQFDLNESHLGHAQDEANLGSRFLFHWV 241
            .|.   .|:|             |:.|:...|.: :....:|..|.|          :|....|.
Worm   186 CFA---DPRG-------------AKTDDEKASSK-SAASPELQSSFL----------NRLTLWWF 223

  Fly   242 QPLILKGVAGKLRKIEDLFDLPDALNITRLS-------EKLHLALSQSQSLW------------- 286
            ..:...|....| :|:|:|:|.:......||       |...|......|:|
Worm   224 NSIPWTGARRDL-EIDDIFELNERSGTEFLSELWESFWEPKRLKYIHDTSIWAKKDPSEQEKDPV 287

  Fly   287 ------RALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLRQDHADPNQVYYYALGL----FG 341
                  .:|...|..||.|...|:.::|...||.|.||..||....| .|..::..:.|    |.
Worm   288 VIPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFISA-KNAPFWKGMALSILMFS 351

  Fly   342 STLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKAL----EARGLKESKPDLLNLMSTDTDRIVN 402
            .:.|.::....:.:.|..:..|::..:..::|:|.|    .|| ...:..:::|||:.|.:|...
Worm   352 VSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSAR-RDRTVGEIVNLMAIDVERFQM 415

  Fly   403 SCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPIN--------RWLAKRIGIFSSG 459
            .......|||.|:::...|..|::.||.:.|.||:...:.:|:|        :|..::
Worm   416 ITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNIISSMIVRKWQIEQ------- 473

  Fly   460 LMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSK----RKYLDAMCVYFWA 520
             |..||.|.....|.:.|.|.:|:.|||......|..:|.:||..:.|    |..||:    |..
Worm   474 -MKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDS----FNT 533

  Fly   521 TTPVLMCLLTFGVSVLMGNP---LIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQ 582
            .:|.|:.|.:||..|| .||   |.....:.|:||...|..|:.....::|..::|.||.||:::
Worm   534 ASPFLVALFSFGTFVL-SNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKE 597

  Fly   583 LMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKA-SVLQMKCASFCHDSDEQTSPTPFRMKDI 646
            .:....||....               |..::..:: :.::::..:...|.:|.....  .::|:
Worm   598 FLVAEELDEKCV---------------DRSVNIERSHNAVRVENLTASWDPEEAAGEK--TLQDV 645

  Fly   647 NVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNI 711
            ::......|:.:.|.||.||||.|.|::..:....|.:.|....   .||||.||:|..|:||||
Worm   646 DLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRV---AYVPQQPWIQNMTLRDNI 707

  Fly   712 VWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLL 775
            .:|..||.:.|..||:||||:.|::|| .||...:||.|..|||||:|||:|||||||:..||||
Worm   708 TFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLL 772

  Fly   776 DDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPS------- 831
            ||.||::||||.|||.:..|  ..||:.||||:||..:.....|::||.:.:|::..|
Worm   773 DDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEILVMLEGKIEESGTFEHLI 837

  Fly   832 ---------------------------------------EYMT-QSIELSLDEDADDEQEPTVRR 856
                                                   :||. :.:.|::..|.|:    |:
Worm   838 KRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDVVLTVTNDLDE----TI-- 896

  Fly   857 RSVELSNQYD-----------------KKSLDSLLLEELREYGHLSGNVFTCYWKAVTSPLAFTV 904
            |:.||:.|..                 .:|.:.|:.:|....|.:....:..|.||....|:...
Worm   897 RTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGKVEIATYQLYVKAAGYLLSIAF 961

  Fly   905 LLSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGH--TTKFYLSIFT 967
            :...::....:.|...||:.|..|  .||                  ::.|.|  ...:.|.::.
Worm   962 IGFFIVYMTLQILRSFWLSAWSDE--YDP------------------DSPSAHPMAKGWRLGVYG 1006

  Fly   968 AIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDD 1032
            |:..|.:...........:.|.:|:..:|..|:..:|.:..:|:|.|.:||||||.:.|..|:|.
Worm  1007 ALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDM 1071

  Fly  1033 SLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSP 1097
            .||.....|:..:..:...|.|.:.:.|...:||:|:..|||...:.|...||.:|||.|...||
Worm  1072 MLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSP 1136

  Fly  1098 LYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAG 1162
            :|:||.||:||..:||:......|::|....|:..|:.:.:...:.:|||:||:.:|..::..|.
Worm  1137 IYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAA 1201

  Fly  1163 LLAAITASH--TTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQ--N 1223
            |.|.::...  .|:||::|:.:||||:||..|...:..|:|.|..:|:|||:::|.....|.  .
Worm  1202 LFAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYTNTPNEAPWR 1266

  Fly  1224 ASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALL 1288
            ..| .||..|||::||:.|......|||.|...|..|:....|.|:|||||||||||:|...||.
Worm  1267 IEG-REPAPGWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALF 1330

  Fly  1289 RVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNS 1353
            |:.....|.|.:|.|.:..:.|..||..|.:|.|:|.||.||:|.||||...:.|.:||.|::.:
Worm  1331 RMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELA 1395

  Fly  1354 AAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQA 1418
            ...........||..|:...|.|||.|||||:.||||||::.:|:.:||.|:.:|..:|..||:.
Worm  1396 HLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQET 1460

  Fly  1419 LRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGML 1473
            :|..||.||:..|||||..:...|||:|||.|.|.|...|.:|.:|.::.|..|:
Worm  1461 IREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALMADKNSAFAKMV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	450/1612 (28%)
		ABC_membrane	328..560	CDD:294371	64/254 (25%)
		ABCC_MRP_domain1	621..827	CDD:213217	87/208 (42%)
		ABC_membrane	948..1192	CDD:279056	75/247 (30%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	95/219 (43%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	446/1603 (28%)
		ABC_membrane	310..575	CDD:294371	74/279 (27%)
		ABCC_MRP_domain1	622..826	CDD:213217	87/208 (42%)
		ABC_membrane	976..1227	CDD:279056	77/270 (29%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	95/219 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720