DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and cft-1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_504463.1	Gene:	cft-1 / 178939	WormBaseID:	WBGene00000477	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1338	Identity:	274/1338 - (20%)
Similarity:	558/1338 - (41%)	Gaps:	183/1338 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 YFQFDLN--------ESHLGHAQDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNIT 269
            |:...:|        ::...:.|.:::..|:.|...|..|:.|..:..: .::||..|.:.....
Worm     2 YYSVSVNLSKNARQIQNETENEQAKSSFASKLLELPVSKLLQKCRSSTI-TVDDLPILEEKQCSN 65

  Fly   270 RLSE----KLHLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLRQDHADPN 330
            |:..    |..:..|.....|::....|.        .|:.|..:.:|..|||..|:  |.|:.:
Worm    66 RVMSGFKWKKRVIFSILMKFWKSFAGAFA--------FRMCAIFADYASILLLKYLI--DSAEIS 120

  Fly   331 QVYY-----YALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE--ARGLKESKPD 388
            ...:     ..|.||...|.|.:...| .:.:...|::|...:.|.|.:|||.  :.....::..
Worm   121 ATLFNFFIIAVLILFFMQLKSLLLGVH-TYLVGEDSVEMVTVLNNIIVKKALHLTSENTDWNRSK 184

  Fly   389 LLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRI 453
            :..|::|.::.:.|.....|...|...:|...|:.::..||...:..|:..||:..:...:...
Worm   185 ISKLLTTHSEAVSNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYAVFNIIDSY- 248

  Fly   454 GIFSSGL---MTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMC 515
             ::...|   :..:|.|:......:...:.||:.:||..|..|::.:|.:||....|...:::..
Worm   249 -VYKKSLKVQLKCRDERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKTLSINSFM 312

  Fly   516 VYFWATTPVLMCLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIK 578
            .....|:|.::..::|.|..|..  :.|.....:..:|:...:..||:.....|..:.:|..|..
Worm   313 HSLNVTSPFVITFVSFAVYGLQYEISALRFEDAFVLIAIFNYMRRPLHVIIPSLEIVDKALHSAT 377

  Fly   579 RVQQLMDV---PNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTP 640
            .:.|.:.|   |.::..:...|.:          :..||      :::..|:|..:..:.|
Worm   378 IINQFLIVKQSPKINTKTAPQPPV----------EPDLD------IKILNANFSWNGKDDT---- 422

  Fly   641 FRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRG 705
              :.|:.|.:|.|:.....|....||||.|.:|...|:.|.|.:.|.:   |..:.|.||::...
Worm   423 --LNDVCVHVKKGEKHAFIGFPLCGKSSLLFSITGELKMTKGNMWVSK---GISFAPASPYIFSQ 482

  Fly   706 TIRDNIVWGAQFDEQWYKTVLHACALEEDLQILGG-DLVGVGENGRTLSGGQRARVALARAVYQD 769
            ::::||::|..:.:..|..|:.||.|::|:..|.. :...:|:.|..|:..|:|:::|||.:|:|
Worm   483 SLKENILFGNDYVKSKYDKVIMACDLKKDIFSLPRCEATVLGDKGYVLTSTQKAQISLARCLYED 547

  Fly   770 KKVYLLDDVLSSLDAHVARHIIKHCILR--LLKHKTRIVVTRNIQLFFHANQILQVKDGQL---- 828
            ..:|.||.....:|...:..|....:..  .|:.||.|:.|.||:|......:..:|:|::
Worm   548 ADIYALDKAFGPMDRTTSNKIFTRVLGENGYLRDKTVILATNNIELIKTFTMVHVLKNGKIETSG 612

  Fly   829 ----------LPSEYMTQS-IELSLDEDADDEQEPTVRRRSVELSNQYDKKSLDSLLLEELREYG 882
                      :.|:.:.|| |:..::|...||:.|   |::|...::..||......:|:.....
Worm   613 SYDQILECSEIMSDLLNQSRIDKIIEEKYSDEKPP---RKTVMFDDKVLKKRKKKQSMEDTAPVF 674

  Fly   883 HLSGNVFTCYWKAVTSPLAFTVLLSVVLM--QLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILM 945
            . :.:|:..|::  :....||....|:|:  .:.:.|:..||::|     |||
Worm   675 E-NRSVYPFYFR--SGSFIFTAFYIVLLICRFVFQALAFFWLSFW-----LDP------------ 719

  Fly   946 RPTVGNETESGHTTKF-YLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFN 1009
               |..:.|..:..:: ::...:..|:|..:.|:.....|....::.:..:::.:...:......
Worm   720 ---VWKKVECENCPQYVFIQTMSFFAISAIISTMLSYTFFVLTNVQTSRKLYQHITSAIFAVPMI 781

  Fly  1010 FFDITSVGRILNRFSSDTNTVDDSLPFI--------LNILLAQLAGLVGALCVSLYAMPWLGLVI 1066
            |...|:...::|..:||.:.||...|..        |:||:     :...:||:   :|...:.:
Worm   782 FLSPTNKESLMNMITSDLDIVDTQFPLFFKFSFECTLHILM-----IFAIVCVN---VPVFAIFV 838

  Fly  1067 IPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEE 1131
            :..:...:.|.:.:..|...|..|.............|..:....:|:...:.:......|..:.
Worm   839 VAFLIFLVGLLRYFLPALHKISSLEEQKRDLFLCGSIEDFEARIMVRTFGKTRQTLAKTSVNADI 903

  Fly  1132 SIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCI--------SYALSI 1188
            ..:.::.:.:..:|::||.:.:..|::.....:|:|             |:        .:|||:
Worm   904 LTRCRMARYSTLRWISLRTEFISNLMICMCFFIASI-------------CLKVDYIGNAQFALSV 955

  Fly  1189 TGQL--GDLLHAVAET----EQELVAVERIDQYLQLEEEQNASGSAEPPF--------GWPTQGV 1239
            ...|  .:|:.....|    |.....|:||....:..:|         |.        .||..|.
Worm   956 ASILCISELVSTFIRTTCILESLTPHVQRISNVREYPKE---------PMIDKCTIRDSWPDDGK 1011

  Fly  1240 LSFREVQL---SYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPL-THGEIRL 1300
            :..:.:.:   .||.    .::.::...|..|::||:|:.|:||:.:...|:.::.. ....|.:
Worm  1012 IEIKNLNVFANKYRH----VIKDVSLVIEEREKLGIIGKVGSGKSQLAKTLVMMSSADKESHIVV 1072

  Fly  1301 DQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGG 1365
            |.:::..:.:..||.||.||.|:..:|..|:|.|:||...|.||:||.||:.......:.....|
Worm  1073 DDLDIFEMSVKTLRSRITVIPQKAKIFSDTLRSNIDPCCQFADSDIWLAIEACQLREYVKSLPDG 1137

  Fly  1366 LDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLF 1430
            |...|..  ..:|..|:..:.:.|||||..::..||:.|..:.:.....:.:|:||:.|..|.::
Worm  1138 LHQMVSP--EKMSNEQKCQVNVCRALLKGGQIFVIDQSTKMMKEPIKSLVNEAIRNSLKQSTTIW 1200

  Fly  1431 IAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTI 1468
            |......:...||::|:::|.|.....||:|.|:..::
Worm  1201 IGEDFSDVEHCDRVVVIENGVILTTDTPQNLISEFGSL 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	274/1338 (20%)
		ABC_membrane	328..560	CDD:294371	45/243 (19%)
		ABCC_MRP_domain1	621..827	CDD:213217	56/208 (27%)
		ABC_membrane	948..1192	CDD:279056	37/260 (14%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	58/223 (26%)
cft-1	NP_504463.1	MdlB	76..631	CDD:224055	126/592 (21%)
		ABC_membrane	93..359	CDD:294371	55/278 (20%)
		P-loop_NTPase	407..607	CDD:304359	56/208 (27%)
		ABC_membrane	696..938	CDD:294371	40/269 (15%)
		P-loop_NTPase	1010..1228	CDD:304359	58/223 (26%)
		EcfA2	1012..1234	CDD:224047	60/227 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910