DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and Abcc2

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_038834.2	Gene:	Abcc2 / 12780	MGIID:	1352447	Length:	1543	Species:	Mus musculus

Alignment Length:	1640	Identity:	486/1640 - (29%)
Similarity:	783/1640 - (47%)	Gaps:	288/1640 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QFCPT---GLKPFANETNDLLPCF-QEILLQLPV--YTLFAAISAYNFGNQSRHVVRNGLQLRML 74
            :||.:   .|....:...||..|| |.:|:.:|:  ..|.|....|       .:.|:  :.:..
Mouse     3 EFCNSTFWNLSLLKSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLY-------RIYRS--RTKRF 58

  Fly    75 SIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGE-----LS 134
            :|..|.        :||         ::|...||:::|      :.....|| ...|:     :.
Mouse    59 AITKFY--------LAK---------QVFVVCLLILAA------IDLSLALT-EDTGQATIPPVK 99

  Fly   135 HRGSLLINVVWLTVVVLDAVWLRTSRHFSWWP---WSLATLVCDLLFGVTLI------PKGSAVY 190
            :...:|....||.|:|:........:..||:.   |.| :|:|.:....|||      .|.:..|
Mouse   100 YTNPILYLCTWLLVLVIQHCRQCCIQKNSWFLSMFWIL-SLLCGIFQFQTLIRALLQDSKSNMTY 163

  Fly   191 SSLPRSGVSAREDEGLLSQRYTYFQFDL---------NESHLGHAQD-EANLGSRFLFHWVQPLI 245
            |.|                .:..:.|.:         ..|...||.. .|:..|...|.|....:
Mouse   164 SCL----------------FFVSYGFQIVILILSAFSESSDSTHAPSATASFLSSVTFSWYDSTV 212

  Fly   246 LKGVAGKLRKIEDLFDLPDALNITRLSEKLH-------------------------------LAL 279
            |||....| .|||::|:.:.|....|:.|..                               |..
Mouse   213 LKGYKHPL-TIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTK 276

  Fly   280 SQSQS--------------------------LWRALHRCFGVEFYLIGILRLIADLSGFAGPLLL 318
            .||||                          |.:||.:.|.|......||:|..|:..|..|.||
Mouse   277 KQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLL 341

  Fly   319 G---GLLRQDHADPNQVYYYALGLFGSTLLSAV---CATHFDWRMAMVSMKMRVGVVNSIYRKAL 377
            .   |.::...:.|...|.||:.:|..||:.:.   |...|.:   ::.|.:|..::.|:|:|||
Mouse   342 KFLIGFVKDPDSYPWVGYIYAILMFSVTLIQSFFLQCYFQFCF---VLGMTVRTTIIASVYKKAL 403

  Fly   378 EARGLKESK---PDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFA 439
            ....|...:   .:.:||||.|:.::::.....|..||...::..:::.|:.:||.:.||||...
Mouse   404 TLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLM 468

  Fly   440 ALLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRF 504
            .||:|:|..||.:|.......|..||.||....|.:.|.|.:|..|||..|..::..:|::|||.
Mouse   469 VLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRN 533

  Fly   505 LSKRKYLDAMCVYFWATTPVLMCLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVL 567
            |.:...|..:.::....||.|:.::||.|.||:.  |.|.|...:||:.|..:|..||...|.|:
Mouse   534 LLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVI 598

  Fly   568 NGLIEAWVSIKRVQQLMDVPNLDYSS-----YYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCAS 627
            :.:|:|.||:.|::|.:...:||.|:     :::                      ..:|...||
Mouse   599 SSVIQASVSVDRLEQYLGSDDLDLSAIRHVCHFD----------------------KAVQFSEAS 641

  Fly   628 FCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTG 692
            |..|.|.:.:     ::|:|:|||.||||.:.|.||.||||.:||::..::...|.:.::   ..
Mouse   642 FTWDRDLEAT-----IQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIK---GS 698

  Fly   693 FGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQ 756
            ..||||..|:|.|||:|||::|:::||:.|:.|:.||||..||::| |||:..:||.|..|||||
Mouse   699 IAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQ 763

  Fly   757 RARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQ 819
            :.||:||||.|||..:|:|||.||::|.||.:||....:  ..||..||||:||..|......::
Mouse   764 KHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDE 828

  Fly   820 ILQVKDGQLLP----SEYMTQ-----------------SIELSLDEDADDEQE-----PTVR--- 855
            |:.:..|.:|.    |:.|.:                 ..|.::|.|:::|..     |||.
Mouse   829 IVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIP 893

  Fly   856 --------------------------RRSVELSNQYDKKSLDS------------LLLEELREYG 882
                                      ||...|.:....||:::            |:.:|..|.|
Mouse   894 DDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETG 958

  Fly   883 HLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNL----SDAWLAYWVTETTLDPHKNDTSLDHI 943
            .:..:::..|.:||    .:..||.:|:..:...:    ::.||:.|    |.|..|.
Mouse   959 KVKFSIYLKYLQAV----GWWSLLFIVIFYVLNYVAFIGTNLWLSAW----TSDSEKQ------- 1008

  Fly   944 LMRPTVGNETESGHTTK-FYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAK 1007
                   |.|::..:.: ..:.:|.|:.::..:..|:.:....||...|:..:|.:||..::.|.
Mouse  1009 -------NGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAP 1066

  Fly  1008 FNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPI 1072
            .:|||.|..|||:|||:.|.:||||:||..|...|....|:|..|.:...|.|...::|||:..:
Mouse  1067 MSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSIL 1131

  Fly  1073 YLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQL 1137
            |:|:|..|...||.::||.|...||:|:||:||:.||..||:.....||..:.:.:::.:.|...
Mouse  1132 YVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVF 1196

  Fly  1138 TQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAET 1202
            :...:.:|||:||:|:|.|:|..:.||..|..:..|. ..||..:|.||:||..|..|:...:|.
Mouse  1197 SWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTG-DTVGFVLSNALNITQTLNWLVRMTSEV 1260

  Fly  1203 EQELVAVERIDQYLQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAF 1267
            |..:||||||::|:.::.|.......:||..||.:|.:.|...|:.||..|...|:|||...::.
Mouse  1261 ETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKST 1325

  Fly  1268 ERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVR 1332
            |::|:||||||||:|:...|.|:.....|:|.:|.:::.::.|..||.|:.:|.|:|.||.|.:|
Mouse  1326 EKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLR 1390

  Fly  1333 ENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKV 1397
            .||||.:.:.|.|||.|::.:...:.:.....||..:|...|:|||.||||||||.||:|:.:|:
Mouse  1391 MNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKI 1455

  Fly  1398 VAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLA 1462
            :.:||.|:.:|.|:|..||..:||.|..||::.|||||..:...|:|:|||.|:|.|.|:|:.|.
Mouse  1456 LVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELL 1520

  Fly  1463 SDSSTIFYGMLLAQD 1477
            |:... ||  |:|::
Mouse  1521 SNMGP-FY--LMAKE 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	484/1633 (30%)
		ABC_membrane	328..560	CDD:294371	73/239 (31%)
		ABCC_MRP_domain1	621..827	CDD:213217	90/208 (43%)
		ABC_membrane	948..1192	CDD:279056	82/244 (34%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	92/219 (42%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	484/1633 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..285		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..927		3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820