DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC2

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1613	Identity:	470/1613 - (29%)
Similarity:	780/1613 - (48%)	Gaps:	266/1613 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LKPFANET-----------NDLLPCF-QEILLQLPVYTLFAAISAYNFGNQSRHVVRNGLQLRML 74
            |:.|.|.|           .||..|| |.:|:.:|:..|: .::.:    |..||.::..: |..
Human     2 LEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLW-LLAPW----QLLHVYKSRTK-RSS 60

  Fly    75 SIRTFLAMVLALLPVAKVFAFHQQGVELFAADLLVVSAECIMWVVHSGFLLTARQYGE-----LS 134
            :.:.:||.                  ::|...||:::|      :....:|| ...|:     :.
Human    61 TTKLYLAK------------------QVFVGFLLILAA------IELALVLT-EDSGQATVPAVR 100

  Fly   135 HRGSLLINVVWLTVVVLDAVWLRTSRHFSWW-----PWSLATLVCDLLFGVTLIPKGSAVYSSLP 194
            :....|....||.|::     ::.||.   |     .|.|:      ||.:..|..|:..:.:|.
Human   101 YTNPSLYLGTWLLVLL-----IQYSRQ---WCVQKNSWFLS------LFWILSILCGTFQFQTLI 151

  Fly   195 RSGVSAREDEGLLSQRYTYF-------------QFDLNESHLGHAQDEANLGSRFLFHWVQPLIL 246
            |:.:..  |...|:....:|             .|..|.....:....|:..|...:.|...:||
Human   152 RTLLQG--DNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIIL 214

  Fly   247 KGVAGKLRKIEDLFDLPDALNITRLSEKLH--------------------------------LAL 279
            ||....| .:||::::.:.:....|..|..                                |..
Human   215 KGYKRPL-TLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNK 278

  Fly   280 SQSQS--------------------------LWRALHRCFGVEFYLIGILRLIADLSGFAGPLLL 318
            :||||                          |.:||.:.|.:......:|:|:.|:..|..|.||
Human   279 NQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL 343

  Fly   319 GGLLRQDHADPNQVYYY-----ALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE 378
            ..|:  ..|.....|.:     |:.||.:.|:.:.|...:......:.:|:|..::.|:|:|||.
Human   344 KLLI--SFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALT 406

  Fly   379 ARGLKESK---PDLLNLMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAA 440
            ...|...:   .:.:||||.|..::::.....|..||...::..:::.|:.:||.:.||||....
Human   407 LSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMV 471

  Fly   441 LLIPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFL 505
            |:||||..|:.:........|..||.||....|.:.|.|.:|..|||..|..:::.||::||:.|
Human   472 LVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNL 536

  Fly   506 SKRKYLDAMCVYFWATTPVLMCLLTFGVSVLM--GNPLIASTTYTSVALLYMLIGPLNAFPWVLN 568
            .....|..:.::.:..||||:.::||.|.||:  .|.|.|...:||:.|..:|..||:..|.:::
Human   537 LAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMIS 601

  Fly   569 GLIEAWVSIKRVQQLMDVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSD 633
            .:::|.||.:|:::.:...:||.|:..:             |...|    ..:|...|||..:.|
Human   602 SMLQASVSTERLEKYLGGDDLDTSAIRH-------------DCNFD----KAMQFSEASFTWEHD 649

  Fly   634 EQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQ 698
            .:.:     ::|:|:||.|||||.:.||||.||||.:||::..::...|.:.::..|   .||||
Human   650 SEAT-----VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT---AYVPQ 706

  Fly   699 SPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVAL 762
            ..|:|.|||:|||::|.:|:|:.|:.||.||||..||::| ||||..:||.|..|||||:.|::|
Human   707 QSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISL 771

  Fly   763 ARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKD 825
            |||.||:..:|||||.||::||||.:||....:  ..|||.|||::||.::......::|:.:.:
Human   772 ARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGN 836

  Fly   826 GQLL---------------------------PSEYMT-----------QSIELSLDEDADDEQEP 852
            |.::                           |.|..|           ..:..|::|..:|....
Human   837 GTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASI 901

  Fly   853 TVR-----RRSVELSNQYDKKSLDS------------------------LLLEELREYGHLSGNV 888
            |:|     ||::..|::.:.:.|.|                        |:.:|..|.|.:..::
Human   902 TMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSI 966

  Fly   889 FTCYWKAVTSPLAFTVLLSVVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNET 953
            :..|.:|:.....|.::|:.|:..:....|:.||:.|.:::     |...|.|:    |....:.
Human   967 YLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDS-----KIFNSTDY----PASQRDM 1022

  Fly   954 ESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGR 1018
            ..|        ::.|:.::..:......|..|:..:.|:..:|::||..::.|...|||.|..||
Human  1023 RVG--------VYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGR 1079

  Fly  1019 ILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHA 1083
            |:|||:.|.:||||:||..|...:....|::..|.:...|.|...:::||:..||:|:|..|...
Human  1080 IVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVST 1144

  Fly  1084 SRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLAL 1148
            ||.::||.|...||:|:||:||:.||..||:.....||.:..:|:::.:.|...:...:.:|||:
Human  1145 SRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAI 1209

  Fly  1149 RLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERID 1213
            ||:|:|.|.|..:.|:..|... |.:...||..:|.||:||..|..|:...:|.|..:||||||.
Human  1210 RLELVGNLTVFFSALMMVIYRD-TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERIT 1273

  Fly  1214 QYLQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGRTGA 1278
            :|.::|.|........||..||::|.:.|...|:.||..|...|||||....:.|:||:||||||
Human  1274 EYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGA 1338

  Fly  1279 GKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYD 1343
            ||:|:...|.|:.....|:|.:|.|::.::.|..|||::.:|.|:|.||.|::|.||||.:.:.|
Human  1339 GKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSD 1403

  Fly  1344 SEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLD 1408
            .|||.|::.:...:.:.....||..:|...|.|||.||||||||.||||:.:|::.:||.|:.:|
Human  1404 EEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVD 1468

  Fly  1409 DESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSL 1461
            .|:|..||..::|.|..||::.|||||..:...|:::|||:|:|.|.|:|:.|
Human  1469 LETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEEL 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	470/1613 (29%)
		ABC_membrane	328..560	CDD:294371	70/241 (29%)
		ABCC_MRP_domain1	621..827	CDD:213217	92/208 (44%)
		ABC_membrane	948..1192	CDD:279056	77/243 (32%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	94/219 (43%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	467/1607 (29%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		4/30 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820