DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and CFTR

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_000483.3	Gene:	CFTR / 1080	HGNCID:	1884	Length:	1480	Species:	Homo sapiens

Alignment Length:	1517	Identity:	364/1517 - (23%)
Similarity:	655/1517 - (43%)	Gaps:	334/1517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 DEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKL------HLALSQSQSLW 286
            ::|::.|:..|.|.:|::.||...:| ::.|::.:|...:...|||||      .||..::..|.
Human     7 EKASVVSKLFFSWTRPILRKGYRQRL-ELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLI 70

  Fly   287 RALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLRQDHADPNQ----VYYYALGL----FGST 343
            .||.|||...|...||...:.:::....|||||.::.....|..:    ..|..:||    ...|
Human    71 NALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRT 135

  Fly   344 LL--SAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE--ARGL-KESKPDLLNLMSTDTDRIVNS 403
            ||  .|:...|.      :.|:||:.:.:.||:|.|:  :|.| |.|...|::|:|.:.::....
Human   136 LLLHPAIFGLHH------IGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEG 194

  Fly   404 CISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGL----MTAK 464
            ....||.|..|.::...:.|::..|.|:...|:.|..:|           .:|.:||    |..:
Human   195 LALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVL-----------ALFQAGLGRMMMKYR 248

  Fly   465 D-------ARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKR---KYLDAMCVYFW 519
            |       .||..|:|.::..:.:|...||:.....|..|||.||:...|.   :|.::...:|.
Human   249 DQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFS 313

  Fly   520 ATTPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYML-IGPLNAFPWVLNGLIEAWVSIKRVQ-- 581
            ....|.:.:|.:  :::.|  :|....:|:::...:| :.....|||.:....::..:|.::|
Human   314 GFFVVFLSVLPY--ALIKG--IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDF 374

  Fly   582 -QLMDVPNLDYSSYYNPIM---------RGSG-------------GSGAGDDAPLDAPKASVLQM 623
             |..:...|:|:.....::         .|.|             .:..|||: |.....|:|
Human   375 LQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDS-LFFSNFSLL-- 436

  Fly   624 KCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQE 688
                          .||. :||||..|:.|||:.:.|..|.||:|.|..|:..|:.::|::   :
Human   437 --------------GTPV-LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI---K 483

  Fly   689 LTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDL-QILGGDLVGVGENGRTL 752
            .:....:..|..|:..|||::||::|..:||..|::|:.||.||||: :....|.:.:||.|.||
Human   484 HSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITL 548

  Fly   753 SGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHA 817
            |||||||::||||||:|..:||||.....||....:.|.:.|:.:|:.:||||:||..::....|
Human   549 SGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKA 613

  Fly   818 NQILQVKDG------------QLLP--------------------SEYMTQSI-ELSLDEDA--- 846
            ::||.:.:|            .|.|                    :..:|::: ..||:.||
Human   614 DKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVS 678

  Fly   847 -----------------------------------------------DDEQEPTVRR-------- 856
                                                           :|..||..||
Human   679 WTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSE 743

  Fly   857 ------------------------------------------------RSVELSNQYDKKSLDSL 873
                                                            |.|.|:.|.:...||..
Human   744 QGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIY 808

  Fly   874 -----------LLEELREYGHLSGNVFTCYW------KAVTS------------PLAFTVL--LS 907
                       :.||:.|     .::..|::      .|||:            .|.|.::  |.
Human   809 SRRLSQETGLEISEEINE-----EDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLV 868

  Fly   908 VVLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGH--------TTKFYLS 964
            :.|.::..:|...||.            .:|.|.      ..||.|.|.:        :|..|..
Human   869 IFLAEVAASLVVLWLL------------GNTPLQ------DKGNSTHSRNNSYAVIITSTSSYYV 915

  Fly   965 IFTAIAVSNSLVTLA--RAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDT 1027
            .:..:.|:::|:.:.  |.....:..|..:..:|.|:|..|:.|..:..:....|.||||||.|.
Human   916 FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDI 980

  Fly  1028 NTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSS 1092
            ..:||.||..:...:..|..::||:.|.....|::.:..:|::..::.|:..:...|:.:|:|.|
Human   981 AILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLES 1045

  Fly  1093 NAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLL 1157
            ...||::||...:|:||.|:|:....|.|:..|...|...........:..:|..:|::::..:.
Human  1046 EGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIF 1110

  Fly  1158 VGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQ 1222
            ......::.:|...  ..|.||:.::.|::|...|...:::..:.:..:.:|.|:.:::.:..|.
Human  1111 FIAVTFISILTTGE--GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEG 1173

  Fly  1223 NASGSAEPPFG-------------------WPTQGVLSFREVQLSYREHLAPALRGITFQTEAFE 1268
            ..:.|.:|...                   ||:.|.::.:::...|.|.....|..|:|.....:
Human  1174 KPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQ 1238

  Fly  1269 RIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRE 1333
            |:|::||||:||:::|:|.||:.. |.|||::|.|:..::.|...|:..|||.|:.|:|.||.|:
Human  1239 RVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRK 1302

  Fly  1334 NLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVV 1398
            ||||...:.|.|||.........:::.|..|.||..:...|..||.|.:||:||||::|..||::
Human  1303 NLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367

  Fly  1399 AIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLAS 1463
            .:||.:::||..:...|::.|:.||..||::...||:..:....:.:|:::.::.:..:.|.|.:
Human  1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLN 1432

  Fly  1464 DSSTIFYGMLLAQDIDPGEFIR 1485
            :.|      |..|.|.|.:.::
Human  1433 ERS------LFRQAISPSDRVK 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	360/1502 (24%)
		ABC_membrane	328..560	CDD:294371	60/259 (23%)
		ABCC_MRP_domain1	621..827	CDD:213217	77/218 (35%)
		ABC_membrane	948..1192	CDD:279056	59/253 (23%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	73/219 (33%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	364/1517 (24%)
		ABC_membrane	85..303	CDD:279056	59/234 (25%)
		ABCC_CFTR1	389..670	CDD:213258	87/301 (29%)
		CFTR_R	639..849	CDD:291094	23/214 (11%)
		Disordered R region. /evidence=ECO:0000269\|PubMed:10792060	654..831		19/181 (10%)
		ABC_membrane	866..1147	CDD:279056	67/300 (22%)
		ABCC_CFTR2	1208..1480	CDD:213256	80/248 (32%)
		Interaction with GORASP2. /evidence=ECO:0000269\|PubMed:21884936	1386..1480		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:16331976	1478..1480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53842
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920