DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and ABCC4

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1312	Identity:	424/1312 - (32%)
Similarity:	693/1312 - (52%)	Gaps:	120/1312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 EANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITRLSEKLH-------LAL---SQSQ 283
            :|||.||..|.|:.||...|...:|.: :|::.:........|.|:|.       |..   :|..
Human    15 DANLCSRVFFWWLNPLFKIGHKRRLEE-DDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKP 78

  Fly   284 SLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLRQ-DHADP------NQVYYYALGLFG 341
            ||.||:.:|:...:.::||..||.:.:....|:.||.::.. ::.||      |..|.||..|..
Human    79 SLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTF 143

  Fly   342 STLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALEARGL---KESKPDLLNLMSTDTDRIVNS 403
            .||:.|:....:.:.:....|::||.:.:.||||||....:   |.:...::||:|.|.::....
Human   144 CTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQV 208

  Fly   404 CISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTAKDARL 468
            .:..||.|:.|.:......||::::|.:.|||:....:|:|:.....|......|...|..|||:
Human   209 TVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARI 273

  Fly   469 SATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCLLTFGV 533
            ....|.:.|.:.||:.|||..|...|..||::|:..:.:...|..|.:..:.:...::..:||..
Human   274 RTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTT 338

  Fly   534 SVLMGNPLIAS------TTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNLDYS 592
            .||:|:.:.||      |.|.:|.|...|.     ||..:..:.||.|||:|:|..:   .||..
Human   339 YVLLGSVITASRVFVAVTLYGAVRLTVTLF-----FPSAIERVSEAIVSIRRIQTFL---LLDEI 395

  Fly   593 SYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQLVC 657
            |..|            ...|.|..|...:|...|.:     ::.|.|| .::.::..::.|:|:.
Human   396 SQRN------------RQLPSDGKKMVHVQDFTAFW-----DKASETP-TLQGLSFTVRPGELLA 442

  Fly   658 IEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWY 722
            :.||||.||||.|||::..|..:.|.|.|.   ....||.|.||:..||:|.||::|.:::::.|
Human   443 VVGPVGAGKSSLLSAVLGELAPSHGLVSVH---GRIAYVSQQPWVFSGTLRSNILFGKKYEKERY 504

  Fly   723 KTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHV 786
            :.|:.||||::|||:| .|||..:|:.|.||||||:|||.||||||||..:|||||.||::||.|
Human   505 EKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEV 569

  Fly   787 ARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP----SEYMTQSIELS--LDED 845
            :||:.:.||.::|..|..|:||..:|....|:|||.:|||:::.    :|::...|:..  |.:|
Human   570 SRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKD 634

  Fly   846 ADDEQE------PTVRRRSVELSNQYDKKS---------LDS--------LLLEELREYGHLSGN 887
            .::.::      ||:|.|:...|:.:.::|         |:|        .|.||.|..|.:...
Human   635 NEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQ 699

  Fly   888 VFTCYWKAVTSPLAFTVLLSV-VLMQLTRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTV-- 949
            .:..|::|....:.|..|:.: ...|:...|.|.||:||..:.:             ::..||
Human   700 AYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQS-------------MLNVTVNG 751

  Fly   950 -GNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDI 1013
             ||.||. ....:||.|::.:.|:..|..:||:.|..|..:.::..:|.|:.:.::.|...|||.
Human   752 GGNVTEK-LDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDR 815

  Fly  1014 TSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQ 1078
            ..:||||||||.|...:||.||......:..|..:||.:.|::..:||:.:.::|:..|::.|::
Human   816 NPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRR 880

  Fly  1079 RYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQ 1143
            .:...|||:|||.|...||:::|.:.:||||.|||:.:|..|.|..|....:...:|........
Human   881 YFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945

  Fly  1144 QWLALRLQLLGTLLVGGAGLLAA---ITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQE 1205
            :|.|:||..:..:.|    ::.|   :..:.|.:.|.|||.:||||::.|.....:...||.|..
Human   946 RWFAVRLDAICAMFV----IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENM 1006

  Fly  1206 LVAVERIDQYLQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERI 1270
            :::|||:.:|..||:|........||..||.:||:.|..|...|.......|:.:|...::.|::
Human  1007 MISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKV 1071

  Fly  1271 GIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENL 1335
            ||||||||||:|:::||.|::. ..|:|.:|::....:.|..||:::.:|.|||.||.||:|:||
Human  1072 GIVGRTGAGKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL 1135

  Fly  1336 DPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVET----CGNNLSAGQRQLLCLARALLKNAK 1396
            ||.:...|.|:|:|::.    ..|.:.:..|.||::|    .|:|.|.|||||:|||||:|:..:
Human  1136 DPFNEHTDEELWNALQE----VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQ 1196

  Fly  1397 VVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSL 1461
            ::.|||.|:|:|..:|..||:.:|..|..||:|.|||||..:...|:|:|||.||:.|...|..|
Human  1197 ILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVL 1261

  Fly  1462 ASDSSTIFYGML 1473
            ..:..::||.|:
Human  1262 LQNKESLFYKMV 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	423/1309 (32%)
		ABC_membrane	328..560	CDD:294371	68/246 (28%)
		ABCC_MRP_domain1	621..827	CDD:213217	91/206 (44%)
		ABC_membrane	948..1192	CDD:279056	81/249 (33%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	91/223 (41%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	421/1306 (32%)
		ABC_membrane	96..365	CDD:294371	74/268 (28%)
		ABCC_MRP_domain1	410..610	CDD:213217	91/208 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		5/30 (17%)
		ABC_membrane	718..991	CDD:279056	87/290 (30%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	91/223 (41%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820