DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abcc12

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_002937916.3	Gene:	abcc12 / 100493828	XenbaseID:	XB-GENE-6465370	Length:	1430	Species:	Xenopus tropicalis

Alignment Length:	1436	Identity:	386/1436 - (26%)
Similarity:	662/1436 - (46%)	Gaps:	239/1436 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 HAQDEANLGSRFLFHWVQPLILKGVAGKLRKIE--DLFDLP----DALNITRL----SEKLH--- 276
            |..|.|.|.|....:|:.||..|  |.||.:::  ||:.||    ...|..||    .|:|.
Frog    30 HPIDNAGLFSFMTLNWITPLARK--AYKLSELQMNDLWSLPFHESSETNCQRLQSLWEEELQNHG 92

  Fly   277 -LALSQSQSLWRALHRCFGVEFYLIGILRLIADL-SGFAGP-LLLGGLLRQDHADPNQVYY---Y 335
             ...|.|..|||     |.....|:..|.||..: :.|.|| :.:..||...:...:.:.|   .
Frog    93 KRKASLSLVLWR-----FCRTRSLLAFLSLIITMTASFIGPAIFIRALLEYANTLKHDLRYGLIL 152

  Fly   336 ALGLFGSTLLSAVCATHFDWRMAM-------VSMKMRVGVVNSIYRKALEARGLKESKP----DL 389
            |.|:|.:.|:.:       |..|:       ..::::..|:...::|.|:   ||:|..    :|
Frog   153 ASGIFAAELVRS-------WSFALHWAMNYRTGVRLKGAVLALAFKKMLK---LKQSNDIRTGEL 207

  Fly   390 LNLMSTDTDRIVNSCISFHFFWSIPFKL------------FTTLYLLYLQLGAAFLAGVIFAALL 442
            ||:.|:|..|:..:.       ||...|            :|.|:     ||.:.|.|.....:.
Frog   208 LNMCSSDGQRLFEAA-------SIGCMLAAGPVIGIMGLVYTALF-----LGPSALLGSSVFIIF 260

  Fly   443 IPINRWLAKRIGIFSSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSK 507
            .|.....:|....|....:...|.|:....|.:...|.||:.|||:.|..||:.:|.||..||.|
Frog   261 YPFMMLASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEEKTFLEK 325

  Fly   508 RKYLDAMCVYFWATTPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIE 572
            ..|:.::.........|:..:.||.:.:.:|..|.|:..:|.|.:...:...|...|..:....|
Frog   326 AGYVQSITSGVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMTSALKMIPLAVKAASE 390

  Fly   573 AWVSIKRVQQLM-----DVPN---------LDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQM 623
            |.:||.|.|:|.     |:.|         :|:|..|        .|.:.|.......|....:.
Frog   391 ASISISRFQKLFLMEESDMRNNQRLLSNDLIDFSGAY--------FSWSSDVRSSTLEKQKEAEQ 447

  Fly   624 KCASF-----------CHDSDEQ------TSPTPF-------RMKDINVDIKAGQLVCIEGPVGG 664
            |...|           ...|.|.      |:.:.:       .:.:||..::..:|:.|.|.||.
Frog   448 KQEEFKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIGICGSVGS 512

  Fly   665 GKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHAC 729
            ||:|.:.:|:..:...:|.|.|   :....|..|..|:...::|:||::|.::.|:.|:.||..|
Frog   513 GKTSLILSILGQMTLLEGTVTV---SGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRVLKTC 574

  Fly   730 ALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKH 793
            .|..|::.| .|||..:||.|..||||||.|::||||:|.::.|.||||.||::|..|...:.|.
Frog   575 CLYPDIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQLFKK 639

  Fly   794 CILRLLKHKTRIVVTRNIQLFFHANQILQVKDGQL------------------------------ 828
            .|...:.::..:.||..:|.....:::|.:|:|.:
Frog   640 AIKHGMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQVNSIK 704

  Fly   829 ---------------------------------------------------LPSEYMTQSIEL-- 840
                                                               :.::::|...|:
Frog   705 SDVQCSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKSEMVN 769

  Fly   841 --------------------SLDEDADDEQEPTVRRRSVELSNQYDKKSLDSLLLEELREYGHLS 885
                                ..::|||::::.:|...::.::|. ::::.| |:..|.:..|.:.
Frog   770 RDFMVTDGQITGCKQADQYGDQEDDADEDEKGSVLGNTIIVNNN-ERQNRD-LMEPEEKGCGSVP 832

  Fly   886 GNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNL--SDAWLAYWVTETTLDPHKNDTSLDHILMRPT 948
            ..::..|.||....| |.||.:|:.:..|.::  |:.||:||:.:.:     .:||:  :....|
Frog   833 CPIYWVYIKAAGGAL-FCVLNAVLFIFTTGSMAFSNWWLSYWIKQGS-----GNTSV--VTSNVT 889

  Fly   949 VGNETESGH-TTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFD 1012
            :.::..|.: ..:||:.::.:...:.......|.::|..:.:||:..:|::|.:||:.:....||
Frog   890 LSSDNMSDNPDLEFYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFD 954

  Fly  1013 ITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQ 1077
            .|.:|||||||:.|.:.||..||..|..|:..:..::..|.:..:..||..:.::|:..::..:.
Frog   955 TTPLGRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLIN 1019

  Fly  1078 QRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAA 1142
            :..|...|::|||.:.:.||..:|.|.:|.|:|||::...:..|...||..|:.:.......|.|
Frog  1020 KVSRVLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCA 1084

  Fly  1143 QQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELV 1207
            .:|||:||.|:..:::....:...:...|.. |...||.||||:.:||.....:..|.|||....
Frog  1085 SRWLAVRLDLISMIVITLTSVCIVLMHGHIP-PAYAGLAISYAVQLTGLFQYTVRLVTETEARFT 1148

  Fly  1208 AVERIDQYLQ-LEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIG 1271
            :||||:.|:: ||.|:........|..||.:|.::|..|::.||:.|...|:.|:|.....|:||
Frog  1149 SVERINHYIKNLESEEPLKAKEITPKTWPQEGAITFENVEMRYRDKLPLVLKNISFSIRPKEKIG 1213

  Fly  1272 IVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLD 1336
            ||||||:||:|:...|.|:..|..|.:.:|...:.|:.|..||.::.|:.|:|.||.|::|.|||
Frog  1214 IVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGSIRSNLD 1278

  Fly  1337 PRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAID 1401
            |.:...|.|:|:|::.:.....:.:.:|.|:.:|...|:|.|.|:|||||:|||||:::||:.:|
Frog  1279 PLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSSKVLLLD 1343

  Fly  1402 EGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSS 1466
            |.|:.:|:|:|..||:.::.||..||:|.|||||..:...|||:|:|.|:|.|...|..|.|:..
Frog  1344 EATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKPSVLLSNKK 1408

  Fly  1467 TIFYGM 1472
            :.|:.|
Frog  1409 SRFHAM 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	385/1434 (27%)
		ABC_membrane	328..560	CDD:294371	58/257 (23%)
		ABCC_MRP_domain1	621..827	CDD:213217	68/230 (30%)
		ABC_membrane	948..1192	CDD:279056	69/244 (28%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	90/219 (41%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	386/1436 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010