DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abcc6

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_002932264.3	Gene:	abcc6 / 100493037	XenbaseID:	XB-GENE-6465366	Length:	1500	Species:	Xenopus tropicalis

Alignment Length:	1589	Identity:	454/1589 - (28%)
Similarity:	734/1589 - (46%)	Gaps:	260/1589 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DLLPCFQEILLQ-LPVYTLFAAISAYNFGNQSRHVVRNG---LQLRMLS-IRTFLAMVLALLPVA 90
            |...||...:|. :|...||.....|..     ::.|:|   :::..|| .:|.|..:|.|:...
Frog    26 DFSQCFHNSVLNWIPSIFLFICSPFYVL-----YLRRHGRGYIRMSALSKAKTCLGALLVLVCYT 85

  Fly    91 KVF--------AFHQQGVELFAADLL---VVSAECIMWVVHSGFLLTARQYGELSH-RGSLLINV 143
            ::|        ...|..|.|.:..:|   ::.|.||:            ||..:.. |.|.|:..
Frog    86 ELFYTVWNMTHNVRQAPVFLISPLILGSSMLLATCII------------QYERMQGVRSSALLLF 138

  Fly   144 VWLTVVVLDAVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSAREDEGLLS 208
            .||..::.....|||                          |.:...|..|:          :..
Frog   139 FWLLALLCATFQLRT--------------------------KITTAISEAPQ----------IDK 167

  Fly   209 QRYT----YFQFDLNESHLGHAQD------------------EANLGSRFLFHWVQPLILKGVAG 251
            .|||    ||.|.|.:|.|....|                  |::..|:..|.|...::.:|...
Frog   168 LRYTLFVLYFVFVLAQSVLCTFNDDPPFFSNLKKESNPCPVSESSFLSKVTFSWFTEIMFRGYKQ 232

  Fly   252 KLRKIEDLFDL----------------------------------PDALN------------ITR 270
            .| |.||::.|                                  |..|:            |..
Frog   233 PL-KAEDVWSLRKSDTAEEILTLFSKGVEKECKKANLLKEPTRFSPSTLDNDMWISQTEKSEIEL 296

  Fly   271 LSEKLHLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLR--QDHADPN-QV 332
            |.:..|:.||| ::|.:.:.|.||:.|.|..:|........|..|||:..||:  :|.:.|: |.
Frog   297 LLKNQHIQLSQ-KTLLKVIMRSFGLYFLLSALLMTFYTAFLFISPLLVRLLLQLLKDPSAPSWQG 360

  Fly   333 YYYALGLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKAL--EARGLKESKP-DLLNLMS 394
            :..|:.||......::.....|:...::.|::|..:|.::|:|||  .:.|.|||.. :::||:|
Frog   361 FLVAVFLFICPCCQSLFLHQHDYICYVIGMRLRAAIVGTVYKKALMISSAGRKESSAGEIVNLIS 425

  Fly   395 TDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSG 459
            ||..::::.....::.||.|..:...:|.|:..||.|.||||....|.:|.....|..|......
Frog   426 TDVQKLMDLATCVNYMWSAPVTIIVAMYFLWQTLGIAVLAGVAVFILNLPFMTVFAVIIKRVQEQ 490

  Fly   460 LMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPV 524
            .|..||.|:...:|.:||.|.:|:.|||:.|:.|:...|..||:.:.....|.:..:..:..:|.
Frog   491 QMKQKDGRIKIISEILQGIKVLKLYAWENAFMKKVTEFRLMELKAVKTGALLLSGALAVFVASPF 555

  Fly   525 LMCLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVP 587
            .:.|..|||.:.:.  |.|.|...:.::.||.:|..||..||..:....::.||:||:.:.....
Frog   556 WVSLTMFGVFLALDEKNILDAEKAFVTIILLNILRIPLRMFPMAITLFAQSSVSLKRMVKFFSAE 620

  Fly   588 NLDYSSY-YNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIK 651
            .|:..|. .|                 |:.....:.::..:|...|.|     |..::.||:.|.
Frog   621 ELEPESVDIN-----------------DSLSKHAITIRHGTFTWSSSE-----PPCLQSINIGIP 663

  Fly   652 AGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQ 716
            .|.||.:.|.||.||:|.|||::..::..:|:|   .|.:...||||..|:...|.::|:::|.:
Frog   664 QGTLVAVVGQVGCGKTSLLSALLGEMEKVEGQV---SLMSSVAYVPQQTWIPNATFKENVLFGRK 725

  Fly   717 FDEQWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLS 780
            .::.||..|:.||||..||:|| ||:...:||.|..|||||:.|:::|||||::..||||||.||
Frog   726 MEKCWYDQVVQACALLPDLKILSGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLS 790

  Fly   781 SLDAHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLPSEYMTQSIELSLD 843
            ::||||.:|:.:..|  ..|||.|||::||..:......:.|:.:.||::  ||..|.: ||...
Frog   791 AVDAHVGQHLFEQVIGPSGLLKDKTRVLVTHGVSFLPQMDMIIVMSDGRV--SEVGTYN-ELLQK 852

  Fly   844 EDADDEQEPTVRRRSVELSNQYDKKSLDSL---------------------------------LL 875
            ..|..|...|..|:||.....|::::.:|:                                 |.
Frog   853 NGAFSEFLNTYARKSVVFEESYEEQTPNSIQGAMKMKGKHSARNDTDNETDDVANEIEADAGKLT 917

  Fly   876 E-ELREYGHLSGNVFTCY------WKAVTSPLAFTVLLSVVLMQLTRNLS-DAWLAYWVTETTLD 932
            | ::...|.:..:|:..|      |..:.|.|.|       ::|...:|| :.|:..|..    |
Frog   918 EADVALTGRVKLSVYLEYCKIMGKWYLLISALFF-------IVQQAASLSYNYWIGLWAD----D 971

  Fly   933 PHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHE 997
            |..|.|. .|..:|                |.:::.:.|..:|...|.:......|:..:..:|.
Frog   972 PPVNGTQ-QHTSLR----------------LGVYSFLGVMQALSIFAASSTIIVGGVSVSRQLHS 1019

  Fly   998 KLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALCVSLYAMPWL 1062
            :||..::....:||:.|..|.:.|||:.:.:.:|:::|.:|.:.:..:..:...|.|...|.|..
Frog  1020 RLLYSILRCPLSFFERTPSGNLTNRFAKEMDIIDNTVPQVLMLFIIMMLTIAEILLVISIATPLA 1084

  Fly  1063 GLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQV 1127
            .:..||:..:|..||:.|..:||.:|||.:.:.|||||||.|:|||:..||:.|...||.:|..:
Frog  1085 AVAFIPLGLLYFFLQRFYVASSRQLKRLDAVSKSPLYTHFNESLQGVYVIRAFREQERFIQDNNM 1149

  Fly  1128 KLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQL 1192
            :|..:.:.......|.:||::|...|...:|....::..:...:.| ||||||.:..:|.:||.|
Frog  1150 RLNMNQRFYFCSFVANRWLSVRCDFLSNFIVFTVAIVGVLFRDNIT-PGLVGLAVVNSLRLTGVL 1213

  Fly  1193 GDLLHAVAETEQELVAVERIDQYLQLEEEQN-ASGSAEPPFGWPTQGVLSFREVQLSYREHLAPA 1256
            .:.:|...:.|...|:|||:.:|...|.|.. .|.:|.....||::|.:.|:...|.||..|..|
Frog  1214 KEAVHVATDMETNSVSVERVKEYCDAEPEAPWTSDNASDLSNWPSKGKIEFQNYGLRYRPDLDLA 1278

  Fly  1257 LRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVIT 1321
            |:.:|...:..|::||||||||||:|:...|.|:.....|.|.:|:.::..|.|..||.:|.:|.
Frog  1279 LKNVTASIQQGEKVGIVGRTGAGKSSLTLGLFRILEPATGRICIDEKDISELGLHELRSKITIIP 1343

  Fly  1322 QEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETC---GNNLSAGQRQ 1383
            |:|.||.||:|.||||...:.|::||.|::   .|.|.|...|..:|....|   |.|||.||||
Frog  1344 QDPVLFSGTLRMNLDPFDNYSDNDIWVALQ---LAHLKVFASGLPEGLSYICTEGGENLSVGQRQ 1405

  Fly  1384 LLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLD 1448
            |:|||||||:..|::.:||.|:.:|.|:|..||..:|..|:.||::.|||||..:....|::|.|
Frog  1406 LVCLARALLRKTKILVLDEATAAVDLETDDLIQNTIRKEFEDCTIITIAHRLNTIMDYTRVVVFD 1470

  Fly  1449 DGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            .|.|.|...|.:|. ::..:||.|  |:|
Frog  1471 KGEIVEFDTPATLL-ENKGLFYSM--ARD 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	451/1582 (29%)
		ABC_membrane	328..560	CDD:294371	67/237 (28%)
		ABCC_MRP_domain1	621..827	CDD:213217	81/208 (39%)
		ABC_membrane	948..1192	CDD:279056	67/243 (28%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	93/222 (42%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	454/1589 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010