DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abcc1

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_031748377.1	Gene:	abcc1 / 100145582	XenbaseID:	XB-GENE-960171	Length:	1525	Species:	Xenopus tropicalis

Alignment Length:	1597	Identity:	472/1597 - (29%)
Similarity:	771/1597 - (48%)	Gaps:	245/1597 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ETNDLLPCFQE-ILLQLPVYTLFAAISAYNFGNQSRHVVRNG---LQLRMLS-IRTFLAMVLALL 87
            |..|...|||. :|:.:|...|:..:..|..     ::.:|.   :|:..|: .:|.:..:|.|.
Frog    23 ENPDFTKCFQNTVLIWIPCIYLWFCLPFYFV-----YLRKNDQGYIQMSHLNKAKTAIGFILWLA 82

  Fly    88 PVAKVF-AFHQQGVELFAADLLVVSAECI-MWVVHSGFLLTARQYGELSHRGSLLINVVWLTVVV 150
            ..|.:| :|.::...::.|.:.|||...: :.::.:.||:...:...:...|.:|
Frog    83 CWADLFYSFWERSQSIYRAPVYVVSPTVLGITMLLATFLIQYERIKGVQSSGVML---------- 137

  Fly   151 LDAVWLRTSRHFSWWPWSLATLVCDLLFGVTLIPKGSAVYSSLPRSGVSAREDEGLLSQRYTYFQ 215
                        ::|   :..|:|.:     :|.:...:::..|.:.:....|    :..|.||.
Frog   138 ------------NFW---IVALLCAI-----IIFRSKVLHALKPDAQIDVFRD----TTFYIYFL 178

  Fly   216 FDLNESHLGHAQD------------------EANLGSRFLFHWVQPLILKGV------------- 249
            ..|.|..|....|                  .|:..|:..|.|:..::::|.
Frog   179 LVLVELILSAFPDRPPLFSERVNDPNPCPESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLN 243

  Fly   250 ---------------------------------------AGKLRKIEDLFDLPDALNITRLSEKL 275
                                                   ..||...||:.:..:||.:....::|
Frog   244 KEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKEL 308

  Fly   276 HLALSQSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGPLLLGGLLR----QDHADPNQVYYYA 336
                  ..||.:||::.||..|::....:...|:..|:||.||..|::    :|..|.:...|..
Frog   309 ------EPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTF 367

  Fly   337 LGLFGSTLLSAVCATHFDWRMAMVS-MKMRVGVVNSIYRKAL----EARGLKESKPDLLNLMSTD 396
            |..|.:.|.:.:...:|  .:..|: |:::..||..:|||||    .|| ...:..:::||||.|
Frog   368 LLFFCACLQTLILHKYF--HICFVTGMRLKTAVVGLVYRKALVINNSAR-RTSTIGEIVNLMSVD 429

  Fly   397 TDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLM 461
            ..|.::.....:..||.|.::....|||:..||.:.|||:....||:|:|..:|.:...:....|
Frog   430 AQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQM 494

  Fly   462 TAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLM 526
            ..||.|:....|.:.|.|.:|:.|||..|..|:.|:|::||:.|.|..||.|:..:.|...|.|:
Frog   495 KCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLV 559

  Fly   527 CLLTFGVSVLMG--NPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQLMDVPNL 589
            .|.||.|.||:.  |.|.|...:.|:||..:|..|||..|.|::.:::|.||:||::..:....|
Frog   560 ALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEEL 624

  Fly   590 DYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAGQ 654
            :..|......:.|.||               :.||.|:|....::..|     :||||:.|..|.
Frog   625 EPESIIREPQKSSEGS---------------INMKDATFSWSRNDLPS-----LKDINISIPEGS 669

  Fly   655 LVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDE 719
            ||.:.|.||.||||.|||::..::..||.|.::   ...|||.|..|:|..:::||:::|.:.:|
Frog   670 LVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMK---GSVGYVSQQAWIQNASLKDNVLFGRESNE 731

  Fly   720 QWYKTVLHACALEEDLQIL-GGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLD 783
            ..||.|:.||||..||:|| .||...:||.|..|||||:.||:||||||.:..:|||||.||::|
Frog   732 SMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVD 796

  Fly   784 AHVARHIIKHCI--LRLLKHKTRIVVTRNIQLFFHANQILQVKDGQLLP--------------SE 832
            |||.:||....|  ..:||:||||:||..:......:.|:.:.||::..              :|
Frog   797 AHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVDGKITEVGSYQDLLMQDGAFAE 861

  Fly   833 YMT--QSIELSLDEDA-----DDEQE-----PTVRRR------------SVELSNQYDKKSLD-- 871
            ::.  .:.|.:.|::|     ::|:|     |:..:|            ..:||...:.|||:
Frog   862 FLRTYANAEQNKDQEANTTEVEEEEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQN 926

  Fly   872 -------------SLLLEELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNLSDAWLA 923
                         .|...:..:.|.:...||..|.||:...|.|..:...:...:....|:.||:
Frog   927 KTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLS 991

  Fly   924 YWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAG 988
            .|..:                   .|.|.|:...|.:  ||::.|:..|..:.....:...:..|
Frog   992 LWTDD-------------------KVVNGTQQNTTMR--LSVYGALGFSQGIAVYGYSTAVSLGG 1035

  Fly   989 IKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQLAGLVGALC 1053
            |.|:.|:|..||..|:....:||:.|..|.::||||.:.:|:|:::|.|:.:.:..|..::||..
Frog  1036 ILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACV 1100

  Fly  1054 VSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRAS 1118
            :.|.|.|.:.::|.|:..:|..:|:.|...||.:|||.|.:.||:|:||.|||.|.:.||:....
Frog  1101 IILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQ 1165

  Fly  1119 PRFQRDFQVKLEESIKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCIS 1183
            .||.:....|::|:.:|......:.:|||:||:.:|..:|..|.|.|.|:.: |.:||||||.:|
Frog  1166 KRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRT-TLSPGLVGLSVS 1229

  Fly  1184 YALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQNASGSAE---PPFGWPTQGVLSFREV 1245
            |||.:|..|..|:...:|.|..:|||||:.:|..|::|  |:.:.:   |...||.:|.:.||..
Frog  1230 YALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQE--AAWTVQETAPEATWPHEGKIEFRGY 1292

  Fly  1246 QLSYREHLAPALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPL 1310
            .|.|||.|..||:.|....:..|::||||||||||:|:...|.|:.....|||.:|..||..:.|
Frog  1293 GLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGL 1357

  Fly  1311 SVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGN 1375
            ..||.|:.:|.|:|.||.||:|.||||...:.|.:||.:::.:.....:......|:.:....|.
Frog  1358 HDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGE 1422

  Fly  1376 NLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHA 1440
            |||.|||||:|||||||:..|::.:||.|:.:|.|:|..||..:|..|:.||::.|||||..:..
Frog  1423 NLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMD 1487

  Fly  1441 MDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLAQD 1477
            ..::||||.|::.|..:|.:|..... ||:.|  |:|
Frog  1488 YTKVIVLDKGQVVEFDSPSNLLQQQG-IFFNM--AKD 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	469/1590 (29%)
		ABC_membrane	328..560	CDD:294371	77/238 (32%)
		ABCC_MRP_domain1	621..827	CDD:213217	89/208 (43%)
		ABC_membrane	948..1192	CDD:279056	84/243 (35%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	91/219 (42%)
abcc1	XP_031748377.1	MRP_assoc_pro	5..1524	CDD:188098	472/1597 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000087
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000