DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7806 and abcb10

DIOPT Version :9

Sequence 1:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	716	Identity:	176/716 - (24%)
Similarity:	302/716 - (42%)	Gaps:	104/716 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   794 CILRLLKHK--TRIVVTRNIQLFF--HANQILQVKDGQLLPSEYMTQSIELSLDEDADDEQEPTV 854
            |:|.:.|.:  :::...|...||.  |:..|:.:         |.|.:       |::...:..|
Zfish    53 CVLPVYKGRNISKLSCLRTEGLFSPKHSRHIVAL---------YSTST-------DSNQTSKSVV 101

  Fly   855 RRRSVELSNQYDKKSLDSLL-----LEELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLT 914
            .:.|..      |.:.|||.     :::|.:..|..      .|: :|:.:.|.|:.|.|.|..
Zfish   102 NQESSA------KTTADSLPVPSEDVKKLLQLAHPQ------RWR-LTAAVGFLVISSTVTMSA- 152

  Fly   915 RNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLA 979
                              |......:|.|...||   |..|...|...| :.|.:.:.......|
Zfish   153 ------------------PFFLGKVIDTIYTSPT---EDFSSSLTSLCL-MLTGVFLCGGAANAA 195

  Fly   980 RAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPFILNILLAQ 1044
            |.:|...:|.:....:.|.|...::..:..|||.|..|.::||.|:||..|...|...|:..|..
Zfish   196 RVYLMQISGQQIVRKLRESLFSSILKQELGFFDKTRTGELINRLSADTAIVGRCLTDNLSDGLRS 260

  Fly  1045 LAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGL 1109
            ||.....:.:.||..|.|...::.:||....|...:....|.|.|.:.:|::.......|.:..|
Zfish   261 LAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQDALAEATQLAEERISNL 325

  Fly  1110 TTIRSMRASPRFQRDFQVKLE---ESIKAQLTQSA---AQQWLALRLQLLGTLLVGGAGLLAAIT 1168
            .|:|:........:.:..|::   |..|.:...||   ....|:..:.:|..|..||     .:.
Zfish   326 RTVRAFGKELTEVQKYSQKVDHIFELAKKEAVVSAGFYGVTGLSGNVIILSVLYKGG-----LLM 385

  Fly  1169 ASHTTNPGLVGLCISYA----LSITG---QLGDLLHAVAETEQELVAVER-----IDQYLQLEEE 1221
            ||.....|.:...:.||    :||.|   ...:|:..:....:....::|     :::.|.|..|
Zfish   386 ASEAMTVGQLSSFLMYAFWVGISIAGFSSFYSELMKGLGAGTRLWELIDRKPEFPLNEGLVLTSE 450

  Fly  1222 QNASGSAEPPFGWPTQGVLSFREVQLSYREHL-APALRGITFQTEAFERIGIVGRTGAGKTSVLA 1285
            .             .:|.|.||.|..:|.... :|..:.::....|...:.:||.:|:||:|:::
Zfish   451 L-------------LKGELEFRNVSFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVS 502

  Fly  1286 ALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENL-----DPRHGFYDSE 1345
            .|||:.....|.:.:|..:::.|....||..||.::|||.||..::.||:     ||.....: :
Zfish   503 LLLRLYDPDSGIVSVDGHDIRDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPSQVTVE-D 566

  Fly  1346 IWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDE 1410
            |:.|.:.:.|...:.:...|.|..|...|..||.||:|.:.:|||||||.|::.:||.||.||.|
Zfish   567 IYRAAQIANAHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAE 631

  Fly  1411 SDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFYGMLLA 1475
            ::..:|:||.......|:|.|||||..:.:.|.:.|||..|:.|.|:...|.::...:|..::..
Zfish   632 NEFLVQEALERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVMEIGSHSQLLANDQGLFRKLMEK 696

  Fly  1476 Q 1476
            |
Zfish   697 Q 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	175/710 (25%)
		ABC_membrane	328..560	CDD:294371
		ABCC_MRP_domain1	621..827	CDD:213217	8/36 (22%)
		ABC_membrane	948..1192	CDD:279056	61/256 (24%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	77/225 (34%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	158/622 (25%)
		ABC_membrane	141..402	CDD:279056	65/288 (23%)
		P-loop_NTPase	457..697	CDD:304359	77/240 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000