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Protein Alignment Mettl14 and METTL14

DIOPT Version :9

Sequence 1:	NP_609205.1	Gene:	Mettl14 / 34138	FlyBaseID:	FBgn0032016	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_066012.1	Gene:	METTL14 / 57721	HGNCID:	29330	Length:	456	Species:	Homo sapiens

Alignment Length:	437	Identity:	264/437 - (60%)
Similarity:	302/437 - (69%)	Gaps:	61/437 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDVLKSSQERSRKRRLLLAQTLGLSSVDDLKKALGNAEDINSSRQLNSGGQRE----EEDGGAS 61
            |...|:..:||.:.||.||||.||..|.|.:...|.:.::           |||    .|...||
Human     1 MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDE-----------QREIAETRETCRAS 54

  Fly    62 SSKKTPN-----------------------------------EIIYRDSSTFLKGTQSSNPHNDY 91
            .....||                                   |.||:|||||||||||.||||||
Human    55 YDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDY 119

  Fly    92 CQHFVDTGQRPQNFIRDVGLADRFEEYPKLRELIKLKDKLIQDTASAPMYLKADLKSLDVKTLGA 156
            ||||||||.|||||||||||||||||||||||||:|||:||..:.:.||||:||:::.|::.|..
Human   120 CQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTP 184

  Fly   157 KFDVILIEPPLEEYARAAPSVATVGGAPRVFWNWDDILNLDVGEIAAHRSFVFLWCGSSEGLDMG 221
            ||||||:|||||||.|.....|.     ...|.||||:.|::.||||.|||:||||||.||||:|
Human   185 KFDVILLEPPLEEYYRETGITAN-----EKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLG 244

  Fly   222 RNCLKKWGFRRCEDICWIRTNINKPGHSKQLEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANV 286
            |.||:|||:|||||||||:||.|.||.:|.|:||||||||||||||||||||:||||||||||||
Human   245 RVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANV 309

  Fly   287 DIDLIISEEEEFGSFEKPIEIFHIIEHFCLGRRRLHLFGRDSSIRPGWLTVGPELTNSNFNSELY 351
            ||||||:||.|.|:.|||:|||||||||||||||||||||||:||||||||||.|||||:|:|.|
Human   310 DIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETY 374

  Fly   352 QTYFAEAP---ATGCTSRIELLRPKSPPPNSKVLRGRGRGFPRGRGR 395
            .:||: ||   .||||..||.||||||||.||  ..||.|.|||.||
Human   375 ASYFS-APNSYLTGCTEEIERLRPKSPPPKSK--SDRGGGAPRGGGR 418

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.