DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mettl14 and Mettl14

DIOPT Version :9

Sequence 1:	NP_609205.1	Gene:	Mettl14 / 34138	FlyBaseID:	FBgn0032016	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_006233328.1	Gene:	Mettl14 / 295428	RGDID:	1304822	Length:	456	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	266/434 - (61%)
Similarity:	307/434 - (70%)	Gaps:	55/434 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDVLKSSQERSRKRRLLLAQTLGLSSVDDLKKALGNAED-------------------INSSRQ 46
            |...|:..:||.:.||.||||.||..|.|.:...|.:.::                   .||.|:
  Rat     1 MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNSKRK 65

  Fly    47 LNSGG----------------QREEEDGGASSSKKTP-NEIIYRDSSTFLKGTQSSNPHNDYCQH 94
            ....|                |:|||:        .| .|.||:|||||||||||.|||||||||
  Rat    66 CLDEGETDEDKVEEYKDELEMQQEEEN--------LPYEEEIYKDSSTFLKGTQSLNPHNDYCQH 122

  Fly    95 FVDTGQRPQNFIRDVGLADRFEEYPKLRELIKLKDKLIQDTASAPMYLKADLKSLDVKTLGAKFD 159
            |||||.|||||||||||||||||||||||||:|||:||..:.:.||||:||:::.|::.|..|||
  Rat   123 FVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFD 187

  Fly   160 VILIEPPLEEYARAAPSVATVGGAPRVFWNWDDILNLDVGEIAAHRSFVFLWCGSSEGLDMGRNC 224
            |||:|||||||.|     .|...|....|.||||:.|::.||||.|||:||||||.||||:||.|
  Rat   188 VILLEPPLEEYYR-----ETGIAANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVC 247

  Fly   225 LKKWGFRRCEDICWIRTNINKPGHSKQLEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDID 289
            |:|||:|||||||||:||.|.||.:|.|:||||||||||||||||||||:|||||||||||||||
  Rat   248 LRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDID 312

  Fly   290 LIISEEEEFGSFEKPIEIFHIIEHFCLGRRRLHLFGRDSSIRPGWLTVGPELTNSNFNSELYQTY 354
            |||:||.|.|:.|||:|||||||||||||||||||||||:||||||||||.|||||:|:|.|.:|
  Rat   313 LIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASY 377

  Fly   355 FAEAP---ATGCTSRIELLRPKSPPPNSKVLRGRGRGFPRGRGR 395
            |: ||   .||||..||.||||||||.||  ..||.|.|||.||
  Rat   378 FS-APNSYLTGCTEEIERLRPKSPPPKSK--SDRGGGAPRGGGR 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mettl14	NP_609205.1	MT-A70	158..340	CDD:282866	138/181 (76%)
Mettl14	XP_006233328.1	MT-A70	186..363	CDD:368270	137/179 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338485
Domainoid	1	1.000	300	1.000	Domainoid score	I1377
eggNOG	1	0.900	-	-		E1_COG4725
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10865
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1264
OMA	1	1.010	-	-		QHG58694
OrthoDB	1	1.010	-	-		D383312at33208
OrthoFinder	1	1.000	-	-		FOG0006579
OrthoInspector	1	1.000	-	-		oto97097
orthoMCL	1	0.900	-	-		OOG6_104881
Panther	1	1.100	-	-	LDO	PTHR13107
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4823
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770