DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ostgamma and TUSC3

DIOPT Version :9

Sequence 1:	NP_609204.2	Gene:	Ostgamma / 34137	FlyBaseID:	FBgn0032015	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001343358.1	Gene:	TUSC3 / 7991	HGNCID:	30242	Length:	348	Species:	Homo sapiens

Alignment Length:	319	Identity:	182/319 - (57%)
Similarity:	243/319 - (76%)	Gaps:	3/319 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLVVALFAIYAAAQSKSKTGLSLSEKVQNLVDMNAKKPLLRFNGPKFREYVKSAPRNYSMIVMLT 76
            ||::.|..|......|.|..| |:|||:.|::.::::.:.|.||.|||:::|:.|||||||||.|
Human    28 LLLLLLLCIQLGGGQKKKENL-LAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFT 91

  Fly    77 ALAPSRQCQICRHAHDEFAIVANSYRFSSTYSNKLFFAMVDFDDGSEVFQLLRLNTAPVFMHFPA 141
            ||.|.|||.:||.|::|:.|:|||:|:||.:.|||||:|||:|:|::|||.|.:|:||.|||||.
Human    92 ALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPP 156

  Fly   142 KGKPKGADTMDIHRVGFAADSIAKFVAERTDITIRIFRPPNYSGTVAMITLVALVGSFLYIRRNN 206
            ||:||.|||.|:.|:||||:.:||::|:|||:.||:|||||||||:|:..||:|||..||:||||
Human   157 KGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNN 221

  Fly   207 LEFLYNKNLWGAIAVFFCFAMISGQMWNHIRGPPLVHKS-QNGGVAYIHGSSQGQLVVETYIVMF 270
            |||:|||..|..:::...|||.||||||||||||..||: .||.|:|||||||.|.|.|::|::.
Human   222 LEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILV 286

  Fly   271 LNAMIVLGMILLIESGTPKAH-NKNRIMAMTGLVLLTVFFSFLLSVFRSKAQGYPYSFL 328
            |||.|.:||:||.|:.|.|.. .|.||:.:.||.|:..|||||||:||||..|||||.|
Human   287 LNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDL 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ostgamma	NP_609204.2	OST3_OST6	164..312	CDD:282594	87/149 (58%)
TUSC3	NP_001343358.1	OST3_OST6	54..342	CDD:398430	167/287 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156592
Domainoid	1	1.000	369	1.000	Domainoid score	I911
eggNOG	1	0.900	-	-		E1_KOG2603
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6937
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2043
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52911
OrthoDB	1	1.010	-	-		D1460433at2759
OrthoFinder	1	1.000	-	-		FOG0002554
OrthoInspector	1	1.000	-	-		otm41821
orthoMCL	1	0.900	-	-		OOG6_101708
Panther	1	1.100	-	-	LDO	PTHR12692
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1886
SonicParanoid	1	1.000	-	-		X2260
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800