DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and MAP3K13

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_004712.1 Gene:MAP3K13 / 9175 HGNCID:6852 Length:966 Species:Homo sapiens


Alignment Length:310 Identity:103/310 - (33%)
Similarity:155/310 - (50%) Gaps:29/310 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   485 INYHRHNSGGLACRLKSSPCDRPVPPTAGLSH---------DKWEIHPMELMLMEELGSGQFGVV 540
            |.:.|..||..........|.|||....|.::         |.||:...|:..::.||||..|.|
Human   118 IQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAV 182

  Fly   541 RRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY-IVTEYMKHG 604
            ..||:|.. :.|:|.::|  .:|.|.    |.:.||:|||::...|||:: .|.| |:.||..||
Human   183 FLGKFRAE-EVAIKKVRE--QNETDI----KHLRKLKHPNIIAFKGVCTQ-APCYCIIMEYCAHG 239

  Fly   605 SLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLA 669
            .|...||...|.   ...||:|....::.||.||..|..|||||.:.|.||...:.||::|||.:
Human   240 QLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS 301

  Fly   670 RYVLDDQYT--SSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEV 732
            : .|.|:.|  |..||   :.|..|||:.....|.|.|:|::||::||:.| |::||..:.::.:
Human   302 K-ELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAI 361

  Fly   733 VERV-QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVA 781
            :..| ...:.|..|.:|......:||..|...|..||:||..:..|.:.:
Human   362 IWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIAS 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 4/19 (21%)
PTKc_Tec_like 521..778 CDD:173637 90/260 (35%)
MAP3K13NP_004712.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..114
STKc_MAP3K12_13 174..410 CDD:270961 90/251 (36%)
Leucine-zipper 1 433..454
Leucine-zipper 2 486..507
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..599
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..655
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..834
Acidic. /evidence=ECO:0000305 815..828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..908
Blue background indicates that the domain is not in the aligned region.

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