DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Tec

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_445884.1	Gene:	Tec / 84492	RGDID:	620973	Length:	629	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	303/756 - (40%)
Similarity:	419/756 - (55%)	Gaps:	144/756 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEAT 104
            ::.:....::||:|.||:.:|:|||.|.|.|||...:|:: ...|::..:|.|.:..::.||  .
  Rat     3 FNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYE-GRAEKKYRKGFIDISKIKCVE--I 64

  Fly   105 VSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSE 169
            |..:.|.....:.:||||.:     .||                            |||:.|.|.
  Rat    65 VKNDDGIIPCQNKFPFQVVH-----DAN----------------------------TLYIFAPSP 96

  Fly   170 KERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGS 234
            :.|..|::.:::..:::|. ...:|||..|:...:.||:...:...||
  Rat    97 QSRDRWVKKLKEEIKNNNN-IMIKYHPKFWADGSYQCCRQTEKLAPGC----------------- 143

  Fly   235 SPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQ 299
                              .:::|..:|                              ...:|.|.
  Rat   144 ------------------EKYNLFESS------------------------------IRKTLPPA 160

  Fly   300 SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE 364
            ..:   |:.|                  |.|..|.   ::|:.  ::|||:|.|:|.|..||.||
  Rat   161 PEI---KRRP------------------PPPIPPE---EENTE--EIVVAMYDFQATEAHDLRLE 199

  Fly   365 KNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429
            :..||.:::.:..|||:.:|..|:.||||||||..|....|::||||..:.:|.:||.||:..||
  Rat   200 RGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDK 264

  Fly   430 EGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQNARC--EYYLSEKHCCETIPDLINYHR 489
            ||.|:||.||..||||:||:||.   ..|..:|||||:.|..  :|||:|||...:||::|.||:
  Rat   265 EGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHK 329

  Fly   490 HNSGGLACRLK--SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTA 552
            ||:.||..||:  .|...:..|.|||.|:|||||:|.||..|.|||||.|||||.||||.....|
  Rat   330 HNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVA 394

  Fly   553 VKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTL 617
            :|.::||.|.|:|||||||||.||.||.||||||||::.:|||||||:|:.|.|||:||:.:
  Rat   395 IKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ--- 456

  Fly   618 IGNMG--LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSS 680
             |:..  :||.||..|.:||.||||:::||||||||||||....||||:|||:||||||||||||
  Rat   457 -GHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSS 520

  Fly   681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKP 745
            .|.|||:||.||||.||:|||||||||::|||||||||.|:||:.:..|.|||..|.||..|.:|
  Rat   521 SGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRP 585

  Fly   746 KSCAKEIYDVMKLCWSHGPEERPAFRVLM---DQLALVAQT 783
            |..:|.:|:||..||...||.||:|..|:   |:|....:|
  Rat   586 KLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEET 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	44/177 (25%)
		SH3_Tec_like	346..399	CDD:212702	26/52 (50%)
		SH2_Tec_family	403..505	CDD:198188	52/108 (48%)
		PTKc_Tec_like	521..778	CDD:173637	159/261 (61%)
		Pkinase_Tyr	526..777	CDD:285015	156/255 (61%)
Tec	NP_445884.1	PH_Btk	7..148	CDD:269944	44/212 (21%)
		SH3_Tec	181..235	CDD:212838	26/53 (49%)
		SH2_Tec_Itk	238..345	CDD:198259	51/106 (48%)
		PTKc_Tec_Rlk	363..622	CDD:270685	160/262 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1219
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1302
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1017
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm46240
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870