DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and MAP3K21

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:538 Identity:126/538 - (23%)
Similarity:202/538 - (37%) Gaps:183/538 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 GGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVA 349
            |..|.:.||.|                 :..|.      |||..:..:.:|....::. ..|..|
Human     5 GAAGATDTPVS-----------------SAGGA------PGGSASSSSTSSGGSASAG-AGLWAA 45

  Fly   350 LYPFKAIEGGDLSLEKNAEYEVID-----DSQEHWW--KVKDALGNVGYIPSNYVKPKALLGLER 407
            ||.::|....:|||.:....||:.     ...|.||  :|:..|   |..|:|||.|        
Human    46 LYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRL---GIFPANYVAP-------- 99

  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYL 472
                                                                             
Human   100 ----------------------------------------------------------------- 99

  Fly   473 SEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQF 537
                                    ||..:||...|..|::.: |..:|    .|.|.|.:|:|.|
Human   100 ------------------------CRPAASPAPPPSRPSSPV-HVAFE----RLELKELIGAGGF 135

  Fly   538 GVVRRGKWRGSIDTAVKMMK-----EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIV 597
            |.|.|..|:|. :.|||..:     :...:.:....||::...|:|||:::|.|||.:...:.:|
Human   136 GQVYRATWQGQ-EVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLV 199

  Fly   598 TEYMKHGSLLNYL--------------RRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYI---H 645
            .|:.:.|:|...|              ||..:.   ...:|::..:|:::||.||....::   |
Human   200 LEFARGGALNRALAAANAAPDPRAPGPRRARRI---PPHVLVNWAVQIARGMLYLHEEAFVPILH 261

  Fly   646 RDLAARNCLVGSE--------NVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSS 702
            |||.:.|.|:..:        ..:|:.||||||........|:.||   ..|..|||:..:.||.
Human   262 RDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSK 323

  Fly   703 KSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEK-----PKSCAKEIYDVMKLCWSH 762
            .||:|:||||:||:.| |::||..:....|.    .|:.:.|     |.:|.:....:||.||..
Human   324 GSDIWSYGVLLWELLT-GEVPYRGIDGLAVA----YGVAVNKLTLPIPSTCPEPFAKLMKECWQQ 383

  Fly   763 GPEERPAFRVLMDQLALV 780
            .|..||:|.::::||..:
Human   384 DPHIRPSFALILEQLTAI 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 20/59 (34%)
SH2_Tec_family 403..505 CDD:198188 4/101 (4%)
PTKc_Tec_like 521..778 CDD:173637 86/291 (30%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 10/53 (19%)
SH3_MLK4 42..97 CDD:212991 18/57 (32%)
Protein Kinases, catalytic domain 129..401 CDD:473864 84/283 (30%)
Leucine-zipper 1 425..446
Leucine-zipper 2 460..481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.

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