DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and NCK2

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_003572.2 Gene:NCK2 / 8440 HGNCID:7665 Length:380 Species:Homo sapiens


Alignment Length:480 Identity:94/480 - (19%)
Similarity:157/480 - (32%) Gaps:171/480 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 SERLY--DVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVR 98
            :|||:  |..|:...|:.|.|:..:.|.||..|...|.|.:.    |:|::.....|:...|   
Human    26 NERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSL----VKNLKDTLGLGKTRRK--- 83

  Fly    99 LVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLY 163
                         ..|.|..|        :.|.::....||:|......:.       :|.:..:
Human    84 -------------TSARDASP--------TPSTDAEYPANGSGADRIYDLN-------IPAFVKF 120

  Fly   164 V-IANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREAN 227
            . :|..|.|                                .|..|| ||.|...:.:..|...:
Human   121 AYVAEREDE--------------------------------LSLVKG-SRVTVMEKCSDGWWRGS 152

  Fly   228 NNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCT 292
            .|...|..|:......:...::.:.|..||:..:|                              
Human   153 YNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGAS------------------------------ 187

  Fly   293 PTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIE 357
                              |.||.|                        |..:.:|..||||.::.
Human   188 ------------------LSNGQG------------------------SRVLHVVQTLYPFSSVT 210

  Fly   358 GGDLSLEKNAEYEVID--DSQEHWWKVKDALGNVGYIPSNYV--------------------KPK 400
            ..:|:.||....|||:  ::...|||.|:|.|.||.:|.|||                    .|.
Human   211 EEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPS 275

  Fly   401 ALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQ 464
            :.......|||.|:::|.:||..|.:...||.|::|.| |:...:::||.......|.| ..:..
Human   276 SSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFK-VQLVD 339

  Fly   465 NARCEYYLSEKHCCETIPDLINYHR 489
            |..|   :.::. ..|:.:|:.:::
Human   340 NVYC---IGQRR-FHTMDELVEHYK 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944 31/178 (17%)
SH3_Tec_like 346..399 CDD:212702 23/74 (31%)
SH2_Tec_family 403..505 CDD:198188 22/88 (25%)
PTKc_Tec_like 521..778 CDD:173637
NCK2NP_003572.2 SH3_Nck2_1 2..59 CDD:212832 11/32 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 79..102 5/46 (11%)
SH3_Nck2_2 114..168 CDD:212835 14/86 (16%)
SH3_Nck2_3 198..256 CDD:212836 23/57 (40%)
SH2_Nck2 283..380 CDD:198272 22/83 (27%)
Blue background indicates that the domain is not in the aligned region.

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