Protein Alignment Btk and AT1G18160

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_173254.2
• Gene: AT1G18160 / 838395
• AraportID: AT1G18160
• Length: 992
• Species: Arabidopsis thaliana
• Alignment Length: 747
• Identity: 171/747 - (22%)
• Similarity: 274/747 - (36%)
• Gaps: 208/747 - (27%)

  Fly   107 GEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKE 171
            |:.|.....|....|:.:.:...||:...:::.:...|..|:|
plant   353 GDPGTLIPADAAGLQMDFDDSVYSASPRDVDSSHVASSSSGVE---------------------- 395

  Fly   172 RSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSP 236
                              .|...|...||.:..|..||.             ||.|.:...|...
plant   396 ------------------SSIEEHTESWSAEHRSRTKGS-------------REENQSAGGGDLM 429

  Fly   237 AQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSS 301
            ..|...::.      :.:..:||.||                                  :|..|
plant   430 IPNIREAVG------SQKAPVQHLSS----------------------------------KPTHS 454

  Fly   302 LTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE-- 364
            . |..:||:...            |:.:|.....|.||.|.::.......|..|.:..|:.||
plant   455 F-THARSPSWTE------------GVSSPAGRRMKVKDVSQYMIDAAKENPQLAQKLHDVLLESG 506

  Fly   365 ----KNAEYEVIDDSQEHWWKVK------DALG-NVGYIPSNYVKPKALLGLERYEWYVGDMSRQ 418
                :|...||..:|.|...::|      |..| :.|.|...  :.::.||..|   ::..:.|.
plant   507 VVAPRNLFSEVYSESMEATGEIKSVAESNDEKGKDFGTIQQG--RNQSNLGPVR---FLPPLPRP 566

  Fly   419 RAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQN------------------ 465
            :::::...        :|:.|..||..||.|..: ..|....|.:.:
plant   567 QSKAITHD--------LREHSGSGLGHLSEHCNI-DGHSDSSHSETSTDYPRNVPVAVAAAAVVA 622

  Fly   466 -----ARCEYYLSEKHCCE--------------------TIPDLIN-------YHRHNSGG--LA 496
                 |..:...|:....|                    .:..|.|       .|..:|||  ::
plant   623 SSMVVAAAKSANSDSSTLELSAAAAAAVMATAAAVSRQFELDSLSNGDAGSGGLHGVDSGGERIS 687

  Fly   497 CRL---KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKE 558
            .|.   :||..|..:...|     :.||...|:.:.|.:|.|.:|.|.||.|.|:.....|.:.:
plant   688 DRSIGNESSKSDAAIDDVA-----ECEILWEEITVAERIGLGSYGEVYRGDWHGTAVAVKKFIDQ 747

  Fly   559 GTMSE--DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNM 621
            ....|  ::|..|.::|.:|:|||:|...|..::...:.||||::..|||...:.|....|  :.
plant   748 DITGEALEEFRSEVRMMRRLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQL--DE 810

  Fly   622 GLLLDMCIQVSKGMTYLERHN--YIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTK 684
            ...|.|.:..::||.||...|  .:||||.:.|.||....||||.||||:|..: ..|.||..|.
plant   811 RKRLRMALDAARGMNYLHSCNPVIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKV-STYLSSKSTA 874

  Fly   685 FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERV----QRGIILEKP 745
            ...:|..||||.......|.||::|||::||:||. :.|:|::...:||..|    :|   |:.|
plant   875 GTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTL-QQPWGKMNPMQVVGAVGFQHRR---LDIP 935

  Fly   746 KSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            :.....|.|:::.||...|..||:|..:||.|
plant   936 EFVDPGIADIIRKCWQTDPRLRPSFGEIMDSL 967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	16/114 (14%)
		SH3_Tec_like	346..399	CDD:212702	15/65 (23%)
		SH2_Tec_family	403..505	CDD:198188	25/156 (16%)
		PTKc_Tec_like	521..778	CDD:173637	92/265 (35%)
AT1G18160	NP_173254.2	EDR1	154..358	CDD:433922	2/4 (50%)
		STKc_MAP3K-like	721..967	CDD:270901	88/252 (35%)