Protein Alignment Btk and EDR1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_563824.1
• Gene: EDR1 / 837393
• AraportID: AT1G08720
• Length: 933
• Species: Arabidopsis thaliana
• Alignment Length: 696
• Identity: 156/696 - (22%)
• Similarity: 246/696 - (35%)
• Gaps: 202/696 - (29%)

  Fly   118 YPFQVG------YCEISASANSHQLENGNG-----GGSGVGIEGQQSGRAVPQYTLYVIANSEKE 171
            || :||      |...|:..:|.||||.:.     |..|..||..::...:..|.    .|||::
plant   392 YP-KVGPLRNIDYSSPSSVTSSTQLENNSSTAIGKGSRGAIIECSRTNMNIVPYN----QNSEED 451

  Fly   172 RSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSR----TTFGCRAAAHWREANNNPSN 232
            .       :.:..|.|..::                ||..:    |..|......:.:..|||..
plant   452 P-------KNLFADLNPFQN----------------KGADKLYMPTKSGLNNVDDFHQQKNNPLV 493

  Fly   233 GSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQ 297
            |.|||....::.|.|.:....:.|...|                                   |.
plant   494 GRSPAPMMWKNYSCNEAPKRKENSYIEN-----------------------------------LL 523

  Fly   298 PQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLS 362
            |:     ..:.|...|...:...::..|.|    :.|...:||..||..|.....|.:.|
plant   524 PK-----LHRDPRYGNTQSSYATSSSNGAI----SSNVHGRDNVTFVSPVAVPSSFTSTE----- 574

  Fly   363 LEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQG 427
                                            |..:|.          .|.||:|
plant   575 --------------------------------NQFRPS----------IVEDMNR---------- 587

  Fly   428 DKEGCFVVRKSSTKGLYTLSLHTKV-------PQSHVKHYHIKQ-----NARCEYYLSEKHCCET 480
                       :|.....|..||..       .:||: |.|.|.     :..|:..|.:.....:
plant   588 -----------NTNNELDLQPHTAAVVHGQQNDESHI-HDHRKYTSDDISTGCDPRLKDHESTSS 640

  Fly   481 IPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKW 545
            ..|..:|  .|...:........|:.|           |.    :|::.|.:|.|.:|.|....|
plant   641 SLDSTSY--RNDPQVLDDADVGECEIP-----------WN----DLVIAERIGLGSYGEVYHADW 688

  Fly   546 RGSIDTAVKMMKEGTMSE---DDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607
            .|: :.|||...:...|.   .:|..|.::|.:|:|||:|...|..::...:.||||::..|||.
plant   689 HGT-EVAVKKFLDQDFSGAALAEFRSEVRIMRRLRHPNVVFFLGAVTRPPNLSIVTEFLPRGSLY 752

  Fly   608 NYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERH--NYIHRDLAARNCLVGSENVVKVADFGLAR 670
            ..|.|.:..:  :....:.|.:.|:.||..|...  ..:||||...|.||.:...|||.||||:|
plant   753 RILHRPKSHI--DERRRIKMALDVAMGMNCLHTSTPTIVHRDLKTPNLLVDNNWNVKVGDFGLSR 815

  Fly   671 YVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVER 735
             :..:.:.||..|....:|..||||.....:.|.||:::||::||:.|. ::|:..:...:||..
plant   816 -LKHNTFLSSKSTAGTPEWMAPEVLRNEPSNEKCDVYSFGVILWELATL-RLPWRGMNPMQVVGA 878

  Fly   736 V----QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |    :|   ||.||.....:..::..||...|..||:|..|.:.|
plant   879 VGFQNRR---LEIPKELDPVVGRIILECWQTDPNLRPSFAQLTEVL 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	25/118 (21%)
		SH3_Tec_like	346..399	CDD:212702	4/52 (8%)
		SH2_Tec_family	403..505	CDD:198188	18/113 (16%)
		PTKc_Tec_like	521..778	CDD:173637	83/266 (31%)
EDR1	NP_563824.1	EDR1	129..326	CDD:433922
		STKc_MAP3K-like	675..921	CDD:270901	80/253 (32%)