Protein Alignment Btk and CTR1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_195993.1
• Gene: CTR1 / 831748
• AraportID: AT5G03730
• Length: 821
• Species: Arabidopsis thaliana
• Alignment Length: 778
• Identity: 183/778 - (23%)
• Similarity: 274/778 - (35%)
• Gaps: 246/778 - (31%)

  Fly   218 RAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTN---SQFSLQHNSSGSLGG------------ 267
            |....|     :||.|.........  .||....|   |...||..||||..|
plant    56 RGGFDW-----DPSGGGGGDHRLNN--QPNRVGNNMYASSLGLQRQSSGSSFGESSLSGDYYMPT 113

  Fly   268 ---------GVGGGLGGGGSLGLGGGGG----------GGGSCT--------------------- 292
                     .||.....|..||.|||||          .|||.:
plant   114 LSAAANEIESVGFPQDDGFRLGFGGGGGDLRIQMAADSAGGSSSGKSWAQQTEESYQLQLALALR 178

  Fly   293 ----------PTSLQPQSSLTTFKQSPT---------LLNG---------------NG------T 317
                      |..|.|....:..:.||:         .:||               ||      |
plant   179 LSSEATCADDPNFLDPVPDESALRTSPSSAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWT 243

  Fly   318 L-LDANMPGGIPTPGTPNSKAKDNSHFVKLVVALY------PFKAIEG--GDLSLEKNAEYEVID 373
            | :|.:..|.||:  ..:.:|.|:.....|...:.      .||.:..  .|:|.......||:|
plant   244 LCIDLHESGRIPS--IESLRAVDSGVDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVD 306

  Fly   374 ------------------DSQEHWWK--------VKDALGNVGYIPSNYVKPKALL--------- 403
                              |.....||        :...:..:|.:.....:.:|||
plant   307 QLAKLICNRMGGPVIMGEDELVPMWKECIDGLKEIFKVVVPIGSLSVGLCRHRALLFKVLADIID 371

  Fly   404 ------------------------GLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLY 444
                                    ||:|             |.|:....|.|......|...|..
plant   372 LPCRIAKGCKYCNRDDAASCLVRFGLDR-------------EYLVDLVGKPGHLWEPDSLLNGPS 423

  Fly   445 TLSLHT--KVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLIN-------YHR----------- 489
            ::|:.:  :.|:.......:......:.|.|:......:.|..:       :||
plant   424 SISISSPLRFPRPKPVEPAVDFRLLAKQYFSDSQSLNLVFDPASDDMGFSMFHRQYDNPGGENDA 488

  Fly   490 --HNSGGL--------------------ACRLKSSPCDRPVPPTA----GLSHDKWEIHPMELML 528
              .|.||.                    |..:.:.|..:|||..|    ||..|..:|...:|.:
plant   489 LAENGGGSLPPSANMPPQNMMRASNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNI 553

  Fly   529 MEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSED---DFIEEAKVMTKLQHPNLVQLYGVCSK 590
            .|::|:|.||.|.|.:|.|| |.|||::.|.....:   :|:.|..:|.:|:|||:|...|..::
plant   554 KEKIGAGSFGTVHRAEWHGS-DVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQ 617

  Fly   591 HRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN--YIHRDLAARNC 653
            ...:.|||||:..|||...|.:.......:....|.|...|:|||.||...|  .:||||.:.|.
plant   618 PPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNL 682

  Fly   654 LVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT 718
            ||..:..|||.||||:|.......:|......| :|..||||.....:.||||:::||::||:.|
plant   683 LVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTP-EWMAPEVLRDEPSNEKSDVYSFGVILWELAT 746

  Fly   719 CGKMPYGRLKNTEVVERV----QRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            . :.|:|.|...:||..|    :|   ||.|::...::..:::.||::.|.:||:|..:||.|
plant   747 L-QQPWGNLNPAQVVAAVGFKCKR---LEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLL 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	1/3 (33%)
		SH3_Tec_like	346..399	CDD:212702	12/86 (14%)
		SH2_Tec_family	403..505	CDD:198188	22/176 (13%)
		PTKc_Tec_like	521..778	CDD:173637	94/266 (35%)
CTR1	NP_195993.1	EDR1	207..412	CDD:433922	34/219 (16%)
		STKc_MAP3K-like	557..805	CDD:270901	90/253 (36%)