DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Btk29A and Frk

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_077344.1	Gene:	Frk / 79209	RGDID:	621423	Length:	506	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	188/467 - (40%)
Similarity:	267/467 - (57%)	Gaps:	31/467 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 IPTPGT---PNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWW------KV 382
            |..||.   |.:......:|    |||:.::|....|||.....:.:|:|.|.|.||      |.
  Rat    29 IENPGAYCPPEANRSQGQYF----VALFDYEARTAEDLSFHAGDKLQVLDTSHEGWWLARHLEKK 89

  Fly   383 KDALGN--VGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE-SLLKQGDKEGCFVVRKS-STKGL 443
            ...||.  .||||||||.....|..|  .|:.|.:.|..|| .||...::.|.|::|:| |.||.
  Rat    90 GPGLGQQLQGYIPSNYVAEDRSLQAE--PWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGD 152

  Fly   444 YTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDR-P 507
            ::||:   :.:..||||.|::.....::|:.:....|:.:.:||:...|.||..:|: .||.: .
  Rat   153 FSLSV---LDEGVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVNYYTTTSDGLCVKLE-KPCLKIQ 213

  Fly   508 VPPTAGLSH---DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEE 569
            ||....||:   |:|||....:.|::.|||||||.|..|.|..:...|||.:|.|:|..:||:.|
  Rat   214 VPTPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 278

  Fly   570 AKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKG 634
            |::|..|:||.|:|||.||:...||||:||.|:||||..||:....:.| .:...:||..||:.|
  Rat   279 AQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKI-RLTQQVDMAAQVASG 342

  Fly   635 MTYLERHNYIHRDLAARNCLVGSENVVKVADFGLAR-YVLD--DQYTSSGGTKFPIKWAPPEVLN 696
            |.|||..|||||||||||.|||..|:.||||||||| :.:|  |.|.|....|.|:||..||.:.
  Rat   343 MAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIR 407

  Fly   697 YTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWS 761
            ..:||.|||||::|:|::||.|.|||||..:...:|:..:.:...|.:|.:|.::.|.:|..||:
  Rat   408 TNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWN 472

  Fly   762 HGPEERPAFRVL 773
            ..|::||.|..|
  Rat   473 VEPKQRPTFETL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	24/60 (40%)
		SH2_Tec_family	403..505	CDD:198188	32/103 (31%)
		PTKc_Tec_like	521..778	CDD:173637	119/256 (46%)
		Pkinase_Tyr	526..777	CDD:285015	118/251 (47%)
Frk	NP_077344.1	SH3_Src_like	48..105	CDD:212779	22/60 (37%)
		SH2_Src_Frk	113..208	CDD:199831	30/100 (30%)
		PTKc_Frk_like	226..495	CDD:270653	122/260 (47%)
		Pkinase_Tyr	235..488	CDD:285015	118/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820