Protein Alignment Btk and Fgfr1

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_077060.2
• Gene: Fgfr1 / 79114
• RGDID: 620713
• Length: 822
• Species: Rattus norvegicus
• Alignment Length: 333
• Identity: 118/333 - (35%)
• Similarity: 171/333 - (51%)
• Gaps: 49/333 - (14%)

  Fly   491 NSGGL---ACRLKSSPCDRPVPPTAGLSH------DKWEIHPMELMLMEELGSGQFGVV------ 540
            |||.|   ..||.||    ..|..||:|.      .:||:....|:|.:.||.|.||.|
  Rat   438 NSGVLLVRPSRLSSS----GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 498

  Fly   541 --RRGKWRGSIDTAVKMMKEGTMSED--DFIEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEY 600
              .:.|.......||||:|.....:|  |.|.|.::|..: :|.|::.|.|.|::..|:|::.||
  Rat   499 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 563

  Fly   601 MKHGSLLNYLRRHEKTLIGNMGL------------------LLDMCIQVSKGMTYLERHNYIHRD 647
            ...|:|..||:.....     ||                  |:....||::||.||.....||||
  Rat   564 ASKGNLREYLQARRPP-----GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 623

  Fly   648 LAARNCLVGSENVVKVADFGLARYVLD-DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGV 711
            |||||.||..:||:|:|||||||.:.. |.|..:...:.|:||..||.|....::.:||||::||
  Rat   624 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 688

  Fly   712 LMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQ 776
            |:|||||.|..||..:...|:.:.::.|..::||.:|..|:|.:|:.||...|.:||.|:.|::.
  Rat   689 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 753

  Fly   777 L-ALVAQT 783
            | .:||.|
  Rat   754 LDRIVALT 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188	8/16 (50%)
		PTKc_Tec_like	521..778	CDD:173637	101/287 (35%)
Fgfr1	NP_077060.2	IgI_1_FGFR	25..118	CDD:409362
		Ig strand A	25..28	CDD:409362
		Ig strand A'	40..46	CDD:409362
		Ig strand B	49..59	CDD:409362
		Ig strand C	63..68	CDD:409362
		Ig strand C'	71..73	CDD:409362
		Ig strand D	78..82	CDD:409362
		Ig strand E	85..90	CDD:409362
		Ig strand F	96..105	CDD:409362
		Ig strand G	108..118	CDD:409362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..162
		IgI_2_FGFR	153..247	CDD:409443
		Ig strand A	153..156	CDD:409443
		Heparin-binding	160..177
		Ig strand A'	164..169	CDD:409443
		Ig strand B	173..181	CDD:409443
		Ig strand C	187..192	CDD:409443
		Ig strand C'	195..197	CDD:409443
		Ig strand D	206..209	CDD:409443
		Ig strand E	213..218	CDD:409443
		Ig strand F	227..234	CDD:409443
		Ig strand G	237..247	CDD:409443
		Ig	255..359	CDD:472250
		Ig strand B	273..277	CDD:409444
		Ig strand C	286..290	CDD:409444
		Ig strand E	324..328	CDD:409444
		Ig strand F	338..343	CDD:409444
		Ig strand G	351..354	CDD:409444
		PTKc_FGFR1	464..765	CDD:270678	106/303 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..822