Protein Alignment Btk and Fgr

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_077059.2
• Gene: Fgr / 79113
• RGDID: 621319
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 491
• Identity: 199/491 - (40%)
• Similarity: 289/491 - (58%)
• Gaps: 39/491 - (7%)

  Fly   294 TSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEG 358
            :|:.||..      ||..|| .|.:...:..|                  |.:.||||.::|..|
  Rat    42 SSISPQPI------SPAFLN-VGNIRSVSGTG------------------VTIFVALYDYEARTG 81

  Fly   359 GDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAE- 421
            .||:..|..::.::::::..||:.:. :.|..||:|||||.|  :..::..|||.|.:||:.||
  Rat    82 DDLTFTKGEKFHILNNTEYDWWEARSLSSGRTGYVPSNYVAP--VDSIQAEEWYFGKISRKDAER 144

  Fly   422 SLLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPD 483
            .||..|:.:|.|::|:| :|||.|:||:.  .:....|:|||.|::.....||::.:...|::.|
  Rat   145 QLLSDGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDMGGYYITTRAQFESVQD 209

  Fly   484 LINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGS 548
            |:.::...:.|| |.|.::||....|.|.||:.|.|||....:.|...||:|.||.|..|.|..|
  Rat   210 LVRHYMEVNDGL-CYLLTAPCMVMKPQTLGLAKDAWEIDRNSIALDRRLGTGCFGDVWLGTWNCS 273

  Fly   549 IDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYL--R 611
            ...|||.:|.||||...|:|||::|..|:|..|||||.|.|: .|||||||:|.:||||::|  |
  Rat   274 TKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCYGSLLDFLKDR 337

  Fly   612 RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676
            :....::.|   |:||..||::||.|:||.|||||||.|.|.|||...:.|:|||||||.::||:
  Rat   338 KGHNLMLPN---LVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEHLICKIADFGLARLIVDDE 399

  Fly   677 YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII 741
            |....||||||||..||...:.||:.|||||::|:|:.|:.|.|::||..:.|.||:|:|:.|..
  Rat   400 YNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYH 464

  Fly   742 LEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            :..|..|...:|:||:..|...|||||.|..|...|
  Rat   465 MPCPPGCPVSLYEVMEQTWRLDPEERPTFEYLQSFL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	19/53 (36%)
		SH2_Tec_family	403..505	CDD:198188	36/105 (34%)
		PTKc_Tec_like	521..778	CDD:173637	125/259 (48%)
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46		1/3 (33%)
		SH3	68..125	CDD:473055	20/58 (34%)
		SH2_Src_Fgr	128..228	CDD:198230	35/100 (35%)
		Protein Kinases, catalytic domain	255..502	CDD:473864	123/250 (49%)