DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and TYK2

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens


Alignment Length:593 Identity:159/593 - (26%)
Similarity:234/593 - (39%) Gaps:175/593 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 QPQSSLTTFKQSPTLLNGN---GTLLDANMPGGIPTPGTPNSKAKDNSHFVKLV----------- 347
            |..:|..::.::..|::||   ..:|.|.:  |:         |:..|.|:||.           
Human   716 QQLASALSYLENKNLVHGNVCGRNILLARL--GL---------AEGTSPFIKLSDPGVGLGALSR 769

  Fly   348 ---VALYPFKAIE---GGDLSLEKNAE--------YEVIDDSQ--------------EHWWKVKD 384
               |...|:.|.|   ||..||....:        .|:..|.:              :.|     
Human   770 EERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPW----- 829

  Fly   385 ALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKG------- 442
            ||..||..|.|   |:               .|.||:|.:..|       :..||..|       
Human   830 ALPAVGAPPRN---PE---------------DRIRAQSCIPSG-------LVTSSLSGLPAGGPL 869

  Fly   443 --------LYTLSLHTKVPQSHVK-HYHIKQNARCEYYLSEKHC---------CET--------- 480
                    |:.....:.||.:..| |::.:|     :.|.|..|         |.|         
Human   870 AGAQCSPSLFRSLWKSLVPGTQKKEHFYQRQ-----HRLPEPSCPQLATLTSQCLTYEPTQRPSF 929

  Fly   481 ---IPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRR 542
               :.||.....||   ||..|..:| |.|       :.|....|...|..:.:||.|.||.|..
Human   930 RTILRDLTRLQPHN---LADVLTVNP-DSP-------ASDPTVFHKRYLKKIRDLGEGHFGKVSL 983

  Fly   543 GKWRGSID-----TAVKMMKE--GTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSK--HRPIYIVT 598
            ..:..:.|     .|||.:|.  |......:.:|..::..|.|.::::..|.|..  .:.:.:|.
Human   984 YCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVM 1048

  Fly   599 EYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKV 663
            ||:..|||.:||.||.   ||...||| ...|:.:||.||...:||||||||||.|:.::.:||:
Human  1049 EYVPLGSLRDYLPRHS---IGLAQLLL-FAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKI 1109

  Fly   664 ADFGLARYVLD--DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFT-C------ 719
            .|||||:.|.:  :.|........|:.|..||.|...:|...||||::||.::|:.| |      
Human  1110 GDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP 1174

  Fly   720 ------------GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRV 772
                        |:|...||  ||::||.:|   |.:|..|..|:|.:||.||......||.|..
Human  1175 PTKFLELIGIAQGQMTVLRL--TELLERGER---LPRPDKCPCEVYHLMKNCWETEASFRPTFEN 1234

  Fly   773 LMDQLALV 780
            |:..|..|
Human  1235 LIPILKTV 1242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 18/91 (20%)
SH2_Tec_family 403..505 CDD:198188 27/138 (20%)
PTKc_Tec_like 521..778 CDD:173637 96/286 (34%)
TYK2NP_001372133.1 FERM_F1 28..125 CDD:465733
FERM_F2 143..266 CDD:436450
Jak1_Phl 285..432 CDD:465552
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366
SH2 437..534 CDD:472789
Protein Kinases, catalytic domain 589..937 CDD:473864 51/266 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629
PTKc_Tyk2_rpt2 962..1244 CDD:270664 98/290 (34%)
Blue background indicates that the domain is not in the aligned region.

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