DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and TXK

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:XP_024309968.1 Gene:TXK / 7294 HGNCID:12434 Length:530 Species:Homo sapiens


Alignment Length:492 Identity:238/492 - (48%)
Similarity:319/492 - (64%) Gaps:24/492 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   300 SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE 364
            |.|:..|||.|     |.:..:...   |.|..|.|:..:....||   |||.|...|..:|:|.
Human    54 SQLSNKKQSNT-----GRVQPSKRK---PLPPLPPSEVAEEKIQVK---ALYDFLPREPCNLALR 107

  Fly   365 KNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429
            :..||.:::....||||.:|.|||.|.||||||....:..||.||||..:::|.:||.||:|..|
Human   108 RAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESK 172

  Fly   430 EGCFVVRKSSTKGLYTLSLH---TKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHN 491
            ||.|:||.|...|.||:|:.   .:..::.:|||.||:|...::|::|:|..::||:||.||:||
Human   173 EGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHN 237

  Fly   492 SGGLACRLK-----SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT 551
            :.||..||:     ...|   :|.|||.|::||||.|.||..::|:||||||||..|:||..|..
Human   238 AAGLMTRLRYPVGLMGSC---LPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQV 299

  Fly   552 AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKT 616
            |:|.:.||:|||:|||||||||.||.|..||||||||.:.:|:|||||:|::|.||||||.::..
Human   300 AIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK 364

  Fly   617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSG 681
            |...|  ||.:|..:.:||.||||:.|||||||||||||.|..:||::|||:.||||||:|.||.
Human   365 LRKEM--LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSF 427

  Fly   682 GTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPK 746
            |.||||||:||||..:.::|||||||::||||||:||.||||:....|.:|||.:..|..|.:|.
Human   428 GAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPH 492

  Fly   747 SCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783
            .....||:||..||...||.||.|..|:..:..:|:|
Human   493 LAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAET 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 24/52 (46%)
SH2_Tec_family 403..505 CDD:198188 44/109 (40%)
PTKc_Tec_like 521..778 CDD:173637 146/256 (57%)
TXKXP_024309968.1 SH3_TXK 88..142 CDD:212840 26/56 (46%)
SH2_Tec_Txk 146..251 CDD:198261 44/104 (42%)
PTKc_Tec_like 269..524 CDD:173637 146/256 (57%)
Blue background indicates that the domain is not in the aligned region.

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