DRSC/TRiP Functional Genomics Resources

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Protein Alignment Btk and Grap

DIOPT Version :10

Sequence 1:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_082093.1 Gene:Grap / 71520 MGIID:1918770 Length:217 Species:Mus musculus


Alignment Length:220 Identity:57/220 - (25%)
Similarity:110/220 - (50%) Gaps:45/220 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVID-DSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWY 411
            ||||.|:|.|..:|:..|....:::: :..::|:|. :..|..|::|.||::.|.      :.||
Mouse     4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKA-ELRGAEGFVPKNYIRVKP------HPWY 61

  Fly   412 VGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEK 475
            .|.:|||.||..|.:.:..|.|::|:| |:.|.:::|::.   ...|:|:.:.:.|..:|:|.|:
Mouse    62 SGRISRQLAEETLMKRNHLGAFLIRESESSPGEFSVSVNY---GDQVQHFKVLREASGKYFLWEE 123

  Fly   476 HCCETIPDLINYHRHNSGGLACRLKSSPCD-RPV--PPTAGLSHDKWEI---HPMELMLMEELGS 534
            . ..::.:|::::|..:  :|.|.:...|| :|:  |..|..:..:::.   .|.:|.|      
Mouse   124 K-FNSLNELVDFYRTTT--IAKRRQIFLCDEQPLIKPSRACFAQAQFDFSAQDPSQLSL------ 179

  Fly   535 GQFGVVRRGK------------WRG 547
                  |||.            |||
Mouse   180 ------RRGDIVEVVEREDPHWWRG 198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702 16/51 (31%)
SH2_Tec_family 403..505 CDD:198188 26/102 (25%)
PTKc_Tec_like 521..778 CDD:173637 9/42 (21%)
GrapNP_082093.1 SH3_GRAP_N 2..55 CDD:212881 16/51 (31%)
SH2_Grb2_like 56..150 CDD:199828 27/105 (26%)
SH3 162..214 CDD:473055 9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

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