DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btk29A and TEC

DIOPT Version :9

Sequence 1:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster
Sequence 2:	NP_003206.2	Gene:	TEC / 7006	HGNCID:	11719	Length:	631	Species:	Homo sapiens

Alignment Length:	756	Identity:	307/756 - (40%)
Similarity:	419/756 - (55%)	Gaps:	142/756 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEAT 104
            ::.:....::||:|.||:.:|:|||.|.|.|||...:|:: ...|::..:|.|.:..::.||  .
Human     3 FNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKIKCVE--I 64

  Fly   105 VSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSE 169
            |..:.|.....:.|||||.:     .||                            |||:.|.|.
Human    65 VKNDDGVIPCQNKYPFQVVH-----DAN----------------------------TLYIFAPSP 96

  Fly   170 KERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGS 234
            :.|..|::.:::..:::|. ...:|||..|:...:.||:...:...||       |..|
Human    97 QSRDLWVKKLKEEIKNNNN-IMIKYHPKFWTDGSYQCCRQTEKLAPGC-------EKYN------ 147

  Fly   235 SPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQ 299
             ..::|.|...|.:..|.
Human   148 -LFESSIRKALPPAPETK----------------------------------------------- 164

  Fly   300 SSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLE 364
                  |:.|              |..||.      :.:|||.  ::|||:|.|:|.||.||.||
Human   165 ------KRRP--------------PPPIPL------EEEDNSE--EIVVAMYDFQAAEGHDLRLE 201

  Fly   365 KNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDK 429
            :..||.:::.:..|||:.:|..||.||||||||..|....|::||||..:|:|.:||.||:..||
Human   202 RGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDK 266

  Fly   430 EGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIKQNARC--EYYLSEKHCCETIPDLINYHR 489
            ||.|:||.||..||||:||:||.   ..|..:|||||:....  :|||:|||...:||::|.||:
Human   267 EGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHK 331

  Fly   490 HNSGGLACRLK--SSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTA 552
            ||:.||..||:  .|...:..|.|||.|::||||:|.||..|.|||||.|||||.||||.....|
Human   332 HNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVA 396

  Fly   553 VKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTL 617
            :|.::||.|.|:|||||||||.||.||.||||||||::.:|||||||:|:.|.|||:||:.:
Human   397 IKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ--- 458

  Fly   618 IGNMG--LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSS 680
             |:..  :||.||..|.:||.||||:::||||||||||||....||||:|||:||||||||||||
Human   459 -GHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSS 522

  Fly   681 GGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKP 745
            .|.|||:||.||||.||:|||||||||::||||||:||.|:||:.:..|.|||..|.||..|.:|
Human   523 SGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQP 587

  Fly   746 KSCAKEIYDVMKLCWSHGPEERPAFRVLM---DQLALVAQT 783
            |..:..:|:||..||...||.||:|..|:   |:|....:|
Human   588 KLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEET 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	45/177 (25%)
		SH3_Tec_like	346..399	CDD:212702	28/52 (54%)
		SH2_Tec_family	403..505	CDD:198188	52/108 (48%)
		PTKc_Tec_like	521..778	CDD:173637	157/261 (60%)
		Pkinase_Tyr	526..777	CDD:285015	154/255 (60%)
TEC	NP_003206.2	PH_Btk	7..148	CDD:269944	47/191 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178		7/93 (8%)
		SH3_Tec	182..237	CDD:212838	28/54 (52%)
		SH2_Tec_Itk	240..346	CDD:198259	51/105 (49%)
		PTKc_Tec_Rlk	365..624	CDD:270685	158/262 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1267
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1302
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42091
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4487
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860