DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Btk29A and BTK

DIOPT Version :9

Sequence 1:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster
Sequence 2:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens


Alignment Length:773 Identity:302/773 - (39%)
Similarity:411/773 - (53%) Gaps:152/773 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSY--FDVENVERRRERGRIHLKGVRL 99
            |.:..|:.....:||:|.||:.:|:|:|.|.|.||....||  :|.|...|..::|.|.::.:..
Human    33 EAMAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITC 97

  Fly   100 VEEATVSGEGGDPFAPD----------------------GYPFQVGYCEISASANSHQLENGNGG 142
            ||  ||..|...|  |:                      .|||||.|.|                
Human    98 VE--TVVPEKNPP--PERQIPRRGEESSEMEQISIIERFPYPFQVVYDE---------------- 142

  Fly   143 GSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCC 207
                             ..|||.:.:|:.|..||..::.|.. .|:....:|||..|...::.||
Human   143 -----------------GPLYVFSPTEELRKRWIHQLKNVIR-YNSDLVQKYHPCFWIDGQYLCC 189

  Fly   208 KGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGG 272
            ...::...||:.                 .:|...|:.|.||...::..|               
Human   190 SQTAKNAMGCQI-----------------LENRNGSLKPGSSHRKTKKPL--------------- 222

  Fly   273 LGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTP-GTPNSK 336
                               .||..:.|                  :|...:|   |.| ..|.|.
Human   223 -------------------PPTPEEDQ------------------ILKKPLP---PEPAAAPVST 247

  Fly   337 AKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKA 401
            ::     :|.|||||.:..:...||.|.|..||.::::|...||:.:|..|..|||||||| .:|
Human   248 SE-----LKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYV-TEA 306

  Fly   402 LLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIK 463
            ...:|.||||...|:|.:||.||||..|||.|:||.||..|.||:|:..|.   ||..::||.:.
Human   307 EDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVC 371

  Fly   464 QNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK--SSPCDRPVPPTAGLSHDKWEIHPMEL 526
            ...:.:|||:|||...|||:|||||:|||.||..|||  .|..::..|.||||.:..|||.|.:|
Human   372 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDL 436

  Fly   527 MLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591
            ..::|||:||||||:.|||||..|.|:||:|||:||||:||||||||..|.|..||||||||:|.
Human   437 TFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ 501

  Fly   592 RPIYIVTEYMKHGSLLNYLR--RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCL 654
            |||:|:||||.:|.||||||  ||.    .....||:||..|.:.|.|||...::||||||||||
Human   502 RPIFIITEYMANGCLLNYLREMRHR----FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCL 562

  Fly   655 VGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC 719
            |..:.||||:||||:||||||:||||.|:|||::|:|||||.|::||||||:||:|||||||::.
Human   563 VNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 627

  Fly   720 GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
            |||||.|..|:|..|.:.:|:.|.:|...::::|.:|..||....:|||.|::|:..:
Human   628 GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944 50/201 (25%)
SH3_Tec_like 346..399 CDD:212702 24/52 (46%)
SH2_Tec_family 403..505 CDD:198188 53/106 (50%)
PTKc_Tec_like 521..778 CDD:173637 149/259 (58%)
Pkinase_Tyr 526..777 CDD:285015 147/252 (58%)
BTKNP_001274273.1 PH 38..167 CDD:278594 42/165 (25%)
PH_Btk 40..200 CDD:269944 49/197 (25%)
SH3_BTK 251..305 CDD:212839 25/54 (46%)
SH2_Tec_Btk 308..413 CDD:198260 52/104 (50%)
PTKc_Btk_Bmx 431..686 CDD:173657 149/259 (58%)
Pkinase_Tyr 436..685 CDD:285015 147/252 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 316 1.000 Domainoid score I1267
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 572 1.000 Inparanoid score I1050
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52659
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 1 1.000 - - otm42091
orthoMCL 1 0.900 - - OOG6_102306
Panther 1 1.100 - - O PTHR24418
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X592
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.830

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