Protein Alignment Btk and MAP3K7

DIOPT Version :10

• Sequence 1: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Sequence 2: NP_663304.1
• Gene: MAP3K7 / 6885
• HGNCID: 6859
• Length: 606
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 88/263 - (33%)
• Similarity: 130/263 - (49%)
• Gaps: 19/263 - (7%)

  Fly   520 EIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQL 584
            ||...|:.:.|.:|.|.||||.:.|||.. |.|:|.: |.......||.|.:.::::.|||:|:|
Human    30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAK-DVAIKQI-ESESERKAFIVELRQLSRVNHPNIVKL 92

  Fly   585 YGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHN-----YI 644
            ||.|.  .|:.:|.||.:.|||.|.|...|..........:..|:|.|:|:.||  |:     .|
Human    93 YGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL--HSMQPKALI 153

  Fly   645 HRDLAARN-CLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWA 708
            ||||...| .||....|:|:.|||.|    .|..|.....|....|..|||...:.:|.|.||::
Human   154 HRDLKPPNLLLVAGGTVLKICDFGTA----CDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFS 214

  Fly   709 YGVLMWEIFTCGKMPYGRLKNT--EVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFR 771
            :|:::||:.|..| |:..:...  .::..|..|......|:..|.|..:|..|||..|.:||:..
Human   215 WGIILWEVITRRK-PFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSME 278

  Fly   772 VLM 774
            .::
Human   279 EIV 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	87/262 (33%)
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		88/263 (33%)
		STKc_TAK1	42..292	CDD:270960	84/251 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..493